Results 261 to 270 of about 75,534 (305)
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Neurology, 1994
Abstract After 1977, no new antiepileptic drugs (AEDs) were available until felbamate was approved in 1993. Since then, three more new AEDs have been approved for use in the United States: gabapentin, lamotrigine, and topiramate. These new medications have greatly improved the medical treatment of epilepsy.
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Abstract After 1977, no new antiepileptic drugs (AEDs) were available until felbamate was approved in 1993. Since then, three more new AEDs have been approved for use in the United States: gabapentin, lamotrigine, and topiramate. These new medications have greatly improved the medical treatment of epilepsy.
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Current Treatment Options in Neurology, 2008
Generic antiepileptic drugs (AEDs) generally provide safe, effective, lower-cost alternatives to brand-name drugs. To be approved by the US Food and Drug Administration (FDA), manufacturers must show that generic drugs are comparable to brand-name formulations, meeting bioequivalence, dissolution, and manufacturing quality standards. Bioequivalence for
Susan J, Shaw, Gregory L, Krauss
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Generic antiepileptic drugs (AEDs) generally provide safe, effective, lower-cost alternatives to brand-name drugs. To be approved by the US Food and Drug Administration (FDA), manufacturers must show that generic drugs are comparable to brand-name formulations, meeting bioequivalence, dissolution, and manufacturing quality standards. Bioequivalence for
Susan J, Shaw, Gregory L, Krauss
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Clinical Pharmacokinetics, 1979
In an open prospective clinical study, plasma clearance of phenytoin, phenobarbitone and carbamazepine was assessed in 14 epileptic patients during and after pregnancy. Plasma clearance showed a marked increase during pregnancy, reached a maximum just before or after delivery, and then decreased to early pregnancy values.
M, Dam +3 more
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In an open prospective clinical study, plasma clearance of phenytoin, phenobarbitone and carbamazepine was assessed in 14 epileptic patients during and after pregnancy. Plasma clearance showed a marked increase during pregnancy, reached a maximum just before or after delivery, and then decreased to early pregnancy values.
M, Dam +3 more
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Antiepileptic Drug Pharmacogenetics
Therapeutic Drug Monitoring, 2000Until recently, the drug treatment of epilepsy has been empirical. However, in recent years as a result of improved understanding of seizure neurochemistry and mechanisms of action of antiepileptic drugs (AEDs), drug treatment has become somewhat more rational.
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1999
Approximately 20 to 30% of patients with newly diagnosed epilepsy do not have their seizures controlled with currently available antiepileptic drugs. The clinical need for new antiepileptic drugs is therefore clear.
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Approximately 20 to 30% of patients with newly diagnosed epilepsy do not have their seizures controlled with currently available antiepileptic drugs. The clinical need for new antiepileptic drugs is therefore clear.
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Pharmacological Research, 1995
Notwithstanding pharmacokinetics has greatly increased the rational approach to the drug treatment of epilepsies, about 25% of the patients do not respond to the therapy. Therefore, a great effort has been made to discover new antiepileptic drugs effective in refractory seizures.
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Notwithstanding pharmacokinetics has greatly increased the rational approach to the drug treatment of epilepsies, about 25% of the patients do not respond to the therapy. Therefore, a great effort has been made to discover new antiepileptic drugs effective in refractory seizures.
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Clinical Techniques in Small Animal Practice, 1998
Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment. Several levels of assessment are needed in managing an epileptic patient to include the diagnosis, effectiveness of ...
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Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment. Several levels of assessment are needed in managing an epileptic patient to include the diagnosis, effectiveness of ...
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Discontinuing Antiepileptic Drugs
New England Journal of Medicine, 1988When to stop administering a drug is at least as important a treatment decision as when to start. The issue is especially germane to the patient with epilepsy, because the chronic nature of the disorder often necessitates many years of treatment, and there is growing awareness of systemic and neurologic toxicity related to the long-term use of ...
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Continuum, 2010
The goal of epilepsy treatment is no seizures and no side effects. Antiepileptic drugs (AEDs) are the mainstay of treatment. Chronic use, however, often leads to serial drug changes over time, exposing patients with epilepsy (PWE) to recurrent risks due to adverse effects (AEs) and drug interactions.
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The goal of epilepsy treatment is no seizures and no side effects. Antiepileptic drugs (AEDs) are the mainstay of treatment. Chronic use, however, often leads to serial drug changes over time, exposing patients with epilepsy (PWE) to recurrent risks due to adverse effects (AEs) and drug interactions.
openaire +3 more sources