Results 41 to 50 of about 75,534 (305)
ADVERSE EFFECTS OF ANTIEPILEPTIC DRUGS
Эпилепсия и пароксизмальные состояния, 2017 Antiepileptic drugs are frequently associated with a risk of adverse effects, which have an impact on the tolerability and success of treatment. Patients who develop intolerable adverse effects have to discontinue treatment early after initiation or to ...
I. Yu. Kovaleva
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Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Antiepileptic Drug Actions [PDF]
Epilepsia, 1989 Summary: Antiepileptic drugs (AEDs) vary in their efficacy against generalized tonic‐clonic, myoclonic, and absence seizures, suggesting different mechanisms of action. Phenytoin (PHT), carbamazepine (CBZ), and valproate (VPA) reduced the ability of mouse central neurons to sustain high‐frequency repetitive firing of action potentials (SRF) at ...
openaire +3 more sources
Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases
Advanced Science, EarlyView.Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh +17 more
wiley +1 more source
Antiepileptic drugs and suicidality
Drug, Healthcare and Patient Safety, 2010 Jeffery W Britton1, Jerry J Shih21Mayo Clinic, Rochester, MN, USA; 2Mayo Clinic, Jacksonville, FL, USAAbstract: The risk of suicide in patients with epilepsy is significantly higher than the general population. There are many hypotheses as to the reasons
Jeffery W Britton, Jerry J Shih
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Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up
Pediatrics and Neonatology, 2017 We wanted to identify in children with epilepsy the factors associated with seizure control and recurrence after a 2-year remission. Methods: We did a 5-year follow-up of epileptic children whose antiepileptic medication had been stopped.
Inn-Chi Lee +2 more
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Italian Wikipedia and epilepsy: an infodemiological study of online information-seeking behavior [PDF]
, 2018 Wikipedia is the most commonly accessed source of health information by both healthcare professionals and the lay public worldwide. We aimed to evaluate information-seeking behavior of Internet users searching the Italian Wikipedia for articles related ...
Bragazzi, Nicola Luigi +8 more
core +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT A comprehensive synthesis of the broad range of neurodevelopmental and psychiatric manifestations in NF1 is needed to identify knowledge gaps and future directions for NF1 research. In the following scoping review, we identify and summarize the scope of research that examines neurodevelopmental and psychiatric manifestations, both as ...
Meera Chopra +5 more
wiley +1 more source
Choosing Old and New Antiepileptic Drugs in Epilepsy Treatment
Türk Nöroloji Dergisi, 2009 OBJECTIVE: According to recent studies old antiepileptic drugs used without alternative in the treatment of epilepsy, seems to leave their place to new antiepileptic drugs during last two decades.
Semai Bek +5 more
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Challenges in the Treatment of Epilepsy [PDF]
Journal of Kerman University of Medical Sciences, 2012 Epilepsy is one of the most important diseases of nervous system that involves 0.5-1% of the population. In spite of new developments in antiepileptic drugs, between 20-30% of epileptic patients can not be controlled and even those who are controlled ...
H.A Ebrahimi
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