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Yeast Knockout Strain Collection: Driving Functional Genomics, Biotechnological Applications and Human Disease Research

Yeast, EarlyView.
ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley   +1 more source

Amphotericin B and Antifungal Stewardship in Somalia: Irrational Use, Misconceptions, and Emerging Challenges. [PDF]

Infect Drug Resist
Hassan SA.
europepmc   +1 more source

Formulation-Driven Innovation in Antifungal Therapy: From Nanotechnology to AI-Assisted Design. [PDF]

Int J Nanomedicine
Dc R, Mamani M, Baral KC, Kim GL, Jo SY, Han HK.   +5 more
europepmc   +1 more source

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Antifungal Drug Resistance.

Clinical Infectious Diseases, 2003
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
David A Stevens
exaly   +3 more sources

Antifungal Drug Resistance of Pathogenic Fungi

Lancet, The, 2002
Pathogenic fungi have many complex mechanisms of resistance to antifungal drugs. Information about the clinical, cellular, and molecular factors contributing to antifungal-drug resistance continues to accumulate. We critically review the diagnosis, epidemiology, and mechanisms of antifungal drug resistance of pathogenic fungi.
Russell E. Lewis
exaly   +3 more sources

Antifungals: Mechanism of Action and Drug Resistance

Advances in Experimental Medicine and Biology, 2016
There are currently few antifungals in use which show efficacy against fungal diseases. These antifungals mostly target specific components of fungal plasma membrane or its biosynthetic pathways. However, more recent class of antifungals in use is echinocandins which target the fungal cell wall components.
Rajendra Prasad, Abdul Haseeb Shah
exaly   +3 more sources

Molecular basis of antifungal drug resistance in yeasts [PDF]

International Journal of Antimicrobial Agents, 2017
Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance.
Morio, Florent, Jensen, Rasmus Hare, Le Pape, Patrice, Arendrup, Maiken Cavling   +3 more
openaire   +5 more sources

Resistance of Human Fungal Pathogens to Antifungal Drugs

Current Opinion in Microbiology, 2002
Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals.
Dominique Sanglard
exaly   +5 more sources

On Fruits and Fungi: A Risk of Antifungal Usage in Food Storage and Distribution in Driving Drug Resistance in Candida auris.

MBio, 2022
The continuous emergence of antifungal drug resistance is a mounting concern for the treatment of fungal infections worldwide. While many pathogenic fungi exhibit some level of antifungal drug resistance, the identification of Candida auris has brought ...
Joseph Heitman, Vikas Yadav
exaly   +3 more sources

Resistance to Antifungal Drugs

Infectious Disease Clinics of North America, 2021
Pathogenic fungi have several mechanisms of resistance to antifungal drugs, driven by the genetic plasticity and versatility of their homeostatic responses to stressful environmental cues. We critically review the molecular mechanisms of resistance and cellular adaptations of pathogenic fungi in response to antifungals and discuss the factors ...
Ronen, Ben-Ami, Dimitrios P, Kontoyiannis   +1 more
openaire   +2 more sources