Results 231 to 240 of about 68,714 (277)

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Comparative Toxicity of Bordeaux Mixture by Ingestion and Cuticular Contact Under Climate Change Conditions on Trichogramma cordubensis

Entomologia Experimentalis et Applicata, EarlyView.
In the face of environmental contamination to copper, mainly resulting from frequent copper‐based fungicide applications, it is crucial to understand the side effects of these pesticides on non‐target organisms to improve pest management. Trichogramma cordubensis, used as a biological control agent against grape berry moths in vineyards, shows strongly
William Nusillard, Tessie Garinie, Géraldine Groussier, Denis Thiéry, Jacques Frandon, Jérôme Moreau   +5 more
wiley   +1 more source

Impacts of a Sweet Orange Essential Oil–Based Biopesticide on Exorista larvarum, a Parasitoid Tachinid Fly With a Dual Role

Entomologia Experimentalis et Applicata, EarlyView.
Lethal (mortality) and sublethal (fecundity, fertility) effects of the biopesticide Prev‐Am Plus (containing ~6% sweet orange essential oil) were assessed on the tachinid fly Exorista larvarum. Mated females were exposed via contact and oral routes across five concentrations (0.25%–20%) using protocols adapted from Apis mellifera.
Santolo Francati, Fabio Sgolastra, Rafaela Tadei, Maria Luisa Dindo   +3 more
wiley   +1 more source

Mental Health Disorders in End‐Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management

Hemodialysis International, EarlyView.
ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra, Jordan Fangue‐Nelon, Garima Singh   +2 more
wiley   +1 more source

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

Lipid-Based Drug Delivery Systems as Emerging Tools to Overcome Antifungal Resistance. [PDF]

Int J Mol Sci
Arana L, Guridi A, Sevillano E, Tamayo E, Eraso E, Alkorta I, Mate I.   +6 more
europepmc   +1 more source

Molecular Evolution of Antifungal Drug Resistance [PDF]

Annual Review of Microbiology, 2017
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus have transitioned from a rare curiosity to a leading cause of human mortality.
Nicole Robbins, Leah E Cowen
exaly   +4 more sources

Molecular basis of antifungal drug resistance in yeasts

International Journal of Antimicrobial Agents, 2017
International audienceBesides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire re-sistance upon exposure to most antifungal drugs used in the clinic.
Florent Morio, Rasmus Krøger Hare, Patrice Le Pape   +2 more
exaly   +5 more sources