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Antifungal Drug Resistance in Aspergillus
Journal of Infection, 2000This article overviews the emerging problem of antifungaldrug resistance in Aspergillus. Fluconazole and ketocona-zole (KCZ) are inactive against Aspergillus. Validation oftesting procedures for the detection of itraconazole (ITZ)resistance in Aspergillus fumigatusin 19971,2were furthervalidated with posaconazole (SCH-56592)3,4and voricona-zole (VCZ)5 ...
Moore, C.B. +4 more
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Antifungal drug resistance mechanisms
Expert Review of Anti-infective Therapy, 2009Antifungal resistance is a prominent feature in the management of invasive mycoses, with important implications for morbidity and mortality. Microbiological resistance, the most common cause of refractory infection, is associated with a fungal pathogen for which an antifungal MIC is higher than average or within the range designated as the resistant ...
Peman, Javier +2 more
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Invasive Aspergillosis: Resistance to Antifungal Drugs
Mycopathologia, 2012Although the arsenal of agents with anti-Aspergillus activity has expanded over the last decade, mortality due to invasive aspergillosis remains unacceptably high. Resistance of the Aspergillus spp. species to antifungal drugs increased in the last 20 years with the increase in antifungal drugs use and might partially account for treatment failures ...
Inès, Hadrich +7 more
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Antifungal drug resistance to azoles and polyenes
The Lancet Infectious Diseases, 2002There is an increased awareness of the morbidity and mortality associated with fungal infections caused by resistant fungi in various groups of patients. Epidemiological studies have identified risk factors associated with antifungal drug resistance.
Mar, Masiá Canuto +1 more
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Antifungal Drugs and Resistance
1995From the late 1950’s, extending for two decades thereafter, amphotericin B was the only broad spectrum antifungal drug which could be systemically administered. Because it was the only option, and because systemic mycoses were relatively infrequent, there was little interest in understanding the mechanism of action of amphotericin B, or expanding ...
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Strategies to manage antifungal drug resistance
Expert Opinion on Pharmacotherapy, 2011Invasive fungal infections continue to cause significant morbidity and mortality in immunocompromised hosts. From more than half a million deaths from cryptococcosis in sub-Saharan Africa to an unchanging death rate from invasive candidiasis, despite three antifungal classes of drugs, insights into better strategies to reduce therapeutic failures or ...
Hsiang-Kuang, Tseng, John R, Perfect
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Antifungal drug resistance of oral fungi
Odontology, 2010Fungi comprise a minor component of the oral microbiota but give rise to oral disease in a significant proportion of the population. The most common form of oral fungal disease is oral candidiasis, which has a number of presentations. The mainstay for the treatment of oral candidiasis is the use of polyenes, such as nystatin and amphotericin B, and ...
Niimi, Masakazu +2 more
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Metabolic control of antifungal drug resistance
Fungal Genetics and Biology, 2010Fungi have evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by antifungal drugs such as azoles, which inhibit ergosterol biosynthesis inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular circuitry regulated by the molecular chaperone Hsp90 and its ...
Nicole, Robbins +3 more
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Membrane Transporters and Antifungal Drug Resistance
Current Drug Targets, 2000Over the last 30 years or so, the incidence of invasive fungal infections in man has risen dramatically. Patients that become severely immunocompromised because of underlying diseases such as leukemia or recently, acquired immunodeficiency syndrome or patients who undergo cancer chemotherapy or organ transplantation, are particularly susceptible to ...
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Resistance to Antifungal Drugs
2003Abstract Fungal infections caused by fungal pathogens remain quite common in immunocompromised hosts, especially in HIV-infected individuals, and in patients given immunosuppressive drugs or broad-spectrum antibiotics. Candida spp. represent the major group of yeast species recovered from these infected individuals; however, other yeasts
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