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Resistance to Antifungal Drugs
Infectious Disease Clinics of North America, 2021Pathogenic fungi have several mechanisms of resistance to antifungal drugs, driven by the genetic plasticity and versatility of their homeostatic responses to stressful environmental cues. We critically review the molecular mechanisms of resistance and cellular adaptations of pathogenic fungi in response to antifungals and discuss the factors ...
Ronen, Ben-Ami +1 more
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Antifungal drug resistance of pathogenic fungi
Lancet, The, 2002Pathogenic fungi have many complex mechanisms of resistance to antifungal drugs. Information about the clinical, cellular, and molecular factors contributing to antifungal-drug resistance continues to accumulate. We critically review the diagnosis, epidemiology, and mechanisms of antifungal drug resistance of pathogenic fungi.
Russell E Lewis
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Clinical Infectious Diseases, 2003
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
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The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
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Antifungal Drug Resistance in Aspergillus
Journal of Infection, 2000This article overviews the emerging problem of antifungaldrug resistance in Aspergillus. Fluconazole and ketocona-zole (KCZ) are inactive against Aspergillus. Validation oftesting procedures for the detection of itraconazole (ITZ)resistance in Aspergillus fumigatusin 19971,2were furthervalidated with posaconazole (SCH-56592)3,4and voricona-zole (VCZ)5 ...
Moore, C.B. +4 more
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Metabolic control of antifungal drug resistance
Fungal Genetics and Biology, 2010Fungi have evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by antifungal drugs such as azoles, which inhibit ergosterol biosynthesis inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular circuitry regulated by the molecular chaperone Hsp90 and its ...
Nicole Robbins, Leah E Cowen
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Drug Resistance Updates, 2004
Pharmacodynamics (PDs) describe the relationship between drug exposure and outcome. The drug exposures in these analyses are most commonly expressed in a variety of pharmacokinetic terms. The outcome of interest with anti-infective therapy is either microbiologic resolution or a clinical surrogate of treatment efficacy.
David R Andes
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Pharmacodynamics (PDs) describe the relationship between drug exposure and outcome. The drug exposures in these analyses are most commonly expressed in a variety of pharmacokinetic terms. The outcome of interest with anti-infective therapy is either microbiologic resolution or a clinical surrogate of treatment efficacy.
David R Andes
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Antifungal drug resistance among Candida species: mechanisms and clinical impact
Mycoses, 2015 The epidemiology of Candida infections has changed in recent years. Although Candida albicans is still the main cause of invasive candidiasis in most clinical settings, a substantial proportion of patients is now infected with non-albicans Candida ...
Maurizio Sanguinetti +2 more
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Invasive Aspergillosis: Resistance to Antifungal Drugs
Mycopathologia, 2012Although the arsenal of agents with anti-Aspergillus activity has expanded over the last decade, mortality due to invasive aspergillosis remains unacceptably high. Resistance of the Aspergillus spp. species to antifungal drugs increased in the last 20 years with the increase in antifungal drugs use and might partially account for treatment failures ...
Inès, Hadrich +7 more
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Antifungal drug resistance to azoles and polyenes
The Lancet Infectious Diseases, 2002There is an increased awareness of the morbidity and mortality associated with fungal infections caused by resistant fungi in various groups of patients. Epidemiological studies have identified risk factors associated with antifungal drug resistance.
Mar, Masiá Canuto +1 more
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Antifungal Drugs and Resistance
1995From the late 1950’s, extending for two decades thereafter, amphotericin B was the only broad spectrum antifungal drug which could be systemically administered. Because it was the only option, and because systemic mycoses were relatively infrequent, there was little interest in understanding the mechanism of action of amphotericin B, or expanding ...
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