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Strategies to manage antifungal drug resistance
Expert Opinion on Pharmacotherapy, 2011Invasive fungal infections continue to cause significant morbidity and mortality in immunocompromised hosts. From more than half a million deaths from cryptococcosis in sub-Saharan Africa to an unchanging death rate from invasive candidiasis, despite three antifungal classes of drugs, insights into better strategies to reduce therapeutic failures or ...
Hsiang-Kuang, Tseng, John R, Perfect
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Antifungal drug resistance of oral fungi
Odontology, 2010Fungi comprise a minor component of the oral microbiota but give rise to oral disease in a significant proportion of the population. The most common form of oral fungal disease is oral candidiasis, which has a number of presentations. The mainstay for the treatment of oral candidiasis is the use of polyenes, such as nystatin and amphotericin B, and ...
Niimi, Masakazu +2 more
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Antifungals: Mechanism of Action and Drug Resistance
2016There are currently few antifungals in use which show efficacy against fungal diseases. These antifungals mostly target specific components of fungal plasma membrane or its biosynthetic pathways. However, more recent class of antifungals in use is echinocandins which target the fungal cell wall components.
Rajendra, Prasad +2 more
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Membrane Transporters and Antifungal Drug Resistance
Current Drug Targets, 2000Over the last 30 years or so, the incidence of invasive fungal infections in man has risen dramatically. Patients that become severely immunocompromised because of underlying diseases such as leukemia or recently, acquired immunodeficiency syndrome or patients who undergo cancer chemotherapy or organ transplantation, are particularly susceptible to ...
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Antifungal Drug Resistance: Clinical Relevance and Impact of Antifungal Drug Use
Current Fungal Infection Reports, 2010Antifungal drug resistance significantly impacts treatment outcomes in patients with invasive fungal infections (IFIs). Although primary (intrinsic) resistance may occur independent of previous therapy, prior concomitant antifungal exposure increases the risk for secondary (acquired) resistance and subsequent colonization or infection with less ...
Richard H. Drew, Mary L. Townsend
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Resistance to Antifungal Drugs
2003Abstract Fungal infections caused by fungal pathogens remain quite common in immunocompromised hosts, especially in HIV-infected individuals, and in patients given immunosuppressive drugs or broad-spectrum antibiotics. Candida spp. represent the major group of yeast species recovered from these infected individuals; however, other yeasts
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Fungal infections pose an important threat to public health and food security, and with the rise in antifungal drug and fungicide resistance, we are faced with a global crisis. Currently, humanity is at an intersection of global climate change driving the expansion of species range distributions, emergence of novel pathogenic fungi, and changing at ...
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Antifungal Drug Resistance in Aspergillus
2017A recent database search revealed a steady increase in the number of publications (almost 1000 papers) on antifungal drug resistance/lack of drug susceptibility in aspergillus in peer-reviewed scientific journals from 2000 to 2014 (Fig. 67.1). In contrast, about only 57 publications appeared in scientific journals directly dealing with antimicrobial ...
P. H. Chandrasekar, Elias K. Manavathu
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Resistance of human fungal pathogens to antifungal drugs
Current Opinion in Microbiology, 2002Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals.
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Antifungal drug resistance: not all azoles are equal
Expert Review of Anti-infective Therapy, 2010Response to: Peman J, Canton E, Espinel-Ingroff A. Antifungal drug resistance mechanisms. Expert Rev. Anti Infect. Ther. 7(4), 453–460 (2009).
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