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Antifungal Drug Resistance: Clinical Relevance and Impact of Antifungal Drug Use
Current Fungal Infection Reports, 2010Antifungal drug resistance significantly impacts treatment outcomes in patients with invasive fungal infections (IFIs). Although primary (intrinsic) resistance may occur independent of previous therapy, prior concomitant antifungal exposure increases the risk for secondary (acquired) resistance and subsequent colonization or infection with less ...
Richard H. Drew, Mary L. Townsend
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Fungal infections pose an important threat to public health and food security, and with the rise in antifungal drug and fungicide resistance, we are faced with a global crisis. Currently, humanity is at an intersection of global climate change driving the expansion of species range distributions, emergence of novel pathogenic fungi, and changing at ...
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Antifungal Drug Resistance in Aspergillus
2017A recent database search revealed a steady increase in the number of publications (almost 1000 papers) on antifungal drug resistance/lack of drug susceptibility in aspergillus in peer-reviewed scientific journals from 2000 to 2014 (Fig. 67.1). In contrast, about only 57 publications appeared in scientific journals directly dealing with antimicrobial ...
P. H. Chandrasekar, Elias K. Manavathu
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Drug Resistance Updates, 2004
Pharmacodynamics (PDs) describe the relationship between drug exposure and outcome. The drug exposures in these analyses are most commonly expressed in a variety of pharmacokinetic terms. The outcome of interest with anti-infective therapy is either microbiologic resolution or a clinical surrogate of treatment efficacy.
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Pharmacodynamics (PDs) describe the relationship between drug exposure and outcome. The drug exposures in these analyses are most commonly expressed in a variety of pharmacokinetic terms. The outcome of interest with anti-infective therapy is either microbiologic resolution or a clinical surrogate of treatment efficacy.
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Antifungal drug resistance: not all azoles are equal
Expert Review of Anti-infective Therapy, 2010Response to: Peman J, Canton E, Espinel-Ingroff A. Antifungal drug resistance mechanisms. Expert Rev. Anti Infect. Ther. 7(4), 453–460 (2009).
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Tackling the Emerging Threat of Antifungal Resistance to Human Health
Nature Reviews Microbiology, 2022Adilia Warris +2 more
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Mechanisms of Antifungal Drug Resistance.
2015Antifungal therapy is a central component of patient management for acute and chronic mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal drug classes. Clinical management of fungal diseases is further compromised by the emergence of antifungal drug resistance, which eliminates available drug classes as treatment ...
Cowen, L.E. +4 more
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Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Chemical Reviews, 2021Leah E Cowen +2 more
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