Results 41 to 50 of about 3,193,961 (325)
ANTIFUNGAL RESISTANCE: A GROWING CONCERN
Acta Biológica Colombiana, 2023 Globally, the increasing number of drug-resistant human pathogens represents a major threat to public health. Among these pathogens, fungi that have acquired resistance to the already scarce arsenal of antifungals are of particular significance, as they ...
C. Firacative
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Resistance to antifungals that target CYP51 [PDF]
Journal of Chemical Biology, 2014 Fungal diseases are an increasing global burden. Fungi are now recognised to kill more people annually than malaria, whilst in agriculture, fungi threaten crop yields and food security. Azole resistance, mediated by several mechanisms including point mutations in the target enzyme (CYP51), is increasing through selection pressure as a result of ...
Josie Parker +5 more
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Emerging threats in antifungal-resistant fungal pathogens
Frontiers in Medicine, 2016 The use of antifungal drugs in the therapy of fungal diseases can lead to the development of antifungal resistance. Resistance has been described for virtually all antifungal agents in diverse pathogens including Candida and Aspergilli species.
Dominique eSanglard
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Mechanisms of Antifungal Drug Resistance [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Antifungal therapy is a central component of patient management for acute and chronic mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal drug classes. Clinical management of fungal diseases is further compromised by the emergence of antifungal drug resistance, which eliminates available drug classes as treatment ...
Cowen Leah E +4 more
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HIV & AIDS Review. International Journal of HIV-Related Problems, 2020 Oropharyngeal candidiasis (OPC) is considered the most common fungal infection in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients. Antifungal drug, azole group, is the preferred treatment.
Satutya Wicaksono +4 more
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Examining Signatures of Natural Selection in Antifungal Resistance Genes Across Aspergillus Fungi
Frontiers in Fungal Biology, 2021 Certain Aspergillus fungi cause aspergillosis, a set of diseases that typically affect immunocompromised individuals. Most cases of aspergillosis are caused by Aspergillus fumigatus, which infects millions of people annually.
Renato Augusto Corrêa dos Santos +7 more
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Antifungal drug resistance: an update [PDF]
European Journal of Hospital Pharmacy, 2022 The number of antifungal classes is small, and resistance is becoming a much more frequent problem. Much greater emphasis needs to be placed on susceptibility testing and antifungal stewardship. Such efforts demonstrably improve survival and overall clinical outcomes.
openaire +3 more sources
Emerging Fungal Infections: New Species, New Names, and Antifungal Resistance
Clinical Chemistry, 2021 Background Infections caused by fungi can be important causes of morbidity and mortality in certain patient populations, including those who are highly immunocompromised or critically ill.
N. Wiederhold
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Journal of Fungi, 2022 Background: The increasing burden of candidemia and the emergence of resistance, especially among non-Candida albicans strains, represent a new threat for public health.
Liliana Galia +6 more
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Update on Antifungal Drug Resistance [PDF]
Current Clinical Microbiology Reports, 2015 Invasive fungal infections remain a major source of global morbidity and mortality, especially among patients with underlying immune suppression. Successful patient management requires antifungal therapy. Yet, treatment choices are restricted due to limited classes of antifungal agents and the emergence of antifungal drug resistance.
Erika Shor, Yanan Zhao, David S. Perlin
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