Results 61 to 70 of about 3,193,961 (325)

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal

Microorganisms, 2020
Candida albicans represents the most frequent isolated yeast from bloodstream infections. Despite the remarkable progress in diagnostic and therapeutic approaches, these infections continue to be a critical challenge in intensive care units worldwide ...
S. Costa-de-Oliveira, A. Rodrigues
semanticscholar   +1 more source

The unprecedented epidemic-like scenario of dermatophytosis in India: III. Antifungal resistance and treatment options.

Indian Journal of Dermatology, Venereology and Leprology, 2021
One of the canonical features of the current outbreak of dermatophytosis in India is its unresponsiveness to treatment in majority of cases. Though there appears to be discordance between in vivo and in vitro resistance, demonstration of in vitro ...
S. Verma, Saumya Panda, P. Nenoff, A. Singal, S. Rudramurthy, S. Uhrlass, Anupam Das, Kavita Bisherwal, Dipika Shaw, R. Vasani   +9 more
semanticscholar   +1 more source

Antifungal resistance inAspergillus [PDF]

Medical Mycology, 2005
There are currently few data on drug resistance in Aspergillus, but the recent development of susceptibility tests have made it possible, to some extent, to study resistance in azoles and polyenes. This paper reviews the limited data available. The increased incidence of aspergillosis and the introduction of newer drugs make it important to continue to
openaire   +3 more sources

Combatting the evolution of antifungal resistance in Cryptococcus neoformans

Molecular Microbiology, 2020
Fungal infections are a global concern and the evolution of intrinsic resistance to current antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal pathogen of primarily immunocompromised individuals, resistance toward ...
A. Bermas, J. Geddes-McAlister
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways

Pharmaceuticals
The rising burden of fungal infections presents a significant challenge to global healthcare, particularly with increasing antifungal resistance limiting treatment efficacy.
Helal F. Hetta, Tameem Melhem, Hashim M. Aljohani, Ayman Salama, Rehab Ahmed, Hassabelrasoul Elfadil, Fawaz E. Alanazi, Yasmin N. Ramadan, Basem Battah, Michelangelo Rottura, Matthew Gavino Donadu   +10 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

MARDy: Mycology Antifungal Resistance Database [PDF]

Bioinformatics, 2018
Abstract Summary The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance.
Johanna Rhodes, Thomas R. Sewell, Rhys A. Farrer, Rhys A. Farrer, Jennifer M. G. Shelton, Anthony Nash, Anthony Nash, Alireza Abdolrasouli, Alireza Abdolrasouli, Matthew C. Fisher   +9 more
openaire   +5 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source