Identification and Elimination of Antifungal Tolerance in Candida auris [PDF]
Biomedicines, 2023 Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Samira Rasouli Koohi +3 more
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Hsp21 potentiates antifungal drug tolerance in Candida albicans. [PDF]
PLoS ONE, 2013 Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low number of available antifungal drugs.
François L Mayer +2 more
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mSphere of Influence: Diagnosis of antifungal tolerance and persistence [PDF]
mSphereLei Chen works in the field of clinical diagnosis of antifungal tolerance and persistence. In this mSphere of Influence, he reflects on how the papers “Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with ...
Lei Chen
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Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes [PDF]
mBio, 2023 Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Feng Yang +7 more
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The role of Candida albicans stress response pathways in antifungal tolerance and resistance [PDF]
iScience, 2022 Summary: Human fungal pathogens are the causative agents of devastating diseases across the globe, and the increasing prevalence of drug resistance threatens to undermine the already limited treatment options.
Kali R. Iyer +2 more
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Induction of Antifungal Tolerance Reveals Genetic and Phenotypic Changes in Candida glabrata [PDF]
Journal of FungiCandida glabrata is an opportunistic, pathogenic fungus that is increasingly isolated from hospitalized patients. The incidence of drug tolerance, heteroresistance, and resistance is on the rise due to an overuse of antifungal drugs.
Christy Chedraoui +4 more
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Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of
mSphere, 2019 The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Ryan Kean, Gordon Ramage
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Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi [PDF]
mBioAntifungal drug tolerance and persistence are being increasingly recognized in fungal pathogens. Accordingly, more and more research is being carried out to characterize and understand these phenomena. However, the terminology and methodology employed in
Jorge Amich +3 more
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Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia [PDF]
Nature Communications, 2018 The authors show that antifungal tolerance, defined as the fraction of growth of a fungal pathogen above the minimal inhibitory concentration, is due to the slow growth of subpopulations of cells that overcome drug stress, and that high tolerance is ...
Alexander Rosenberg +9 more
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Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata [PDF]
mBioUpon exposure to echinocandins, growing yeast cells begin to accumulate cell wall damage and eventually die, resulting in therapeutic effects. While resistance to echinocandins is well studied, tolerance and persistence mechanisms that may also ...
Abigail A. Harrington +2 more
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