Results 11 to 20 of about 63,671 (266)

Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis

Frontiers in Microbiology, 2023
Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Liu-liu Sun, Liu-liu Sun, Hao Li, Hao Li, Tian-hua Yan, Yong-bing Cao, Yuan-ying Jiang, Feng Yang   +7 more
doaj   +3 more sources

Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans

mBio, 2021
How cells exposed to one stress are later able to better survive other types of stress is not well understood. In eukaryotic organisms, physiological and pathological stresses can disturb endoplasmic reticulum (ER) function, resulting in “ER stress ...
Feng Yang, Vladimir Gritsenko, Yaniv Slor Futterman, Lu Gao, Cheng Zhen, Hui Lu, Yuan-ying Jiang, Judith Berman   +7 more
doaj   +3 more sources

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal [PDF]

Microorganisms, 2020
Candida albicans represents the most frequent isolated yeast from bloodstream infections. Despite the remarkable progress in diagnostic and therapeutic approaches, these infections continue to be a critical challenge in intensive care units worldwide ...
Sofia Costa-de-Oliveira, Acácio G. Rodrigues   +1 more
doaj   +3 more sources

Antifungal persistence: Clinical relevance and mechanisms. [PDF]

PLoS Pathogens
Antifungal persistence is the phenomenon that occurs when a subpopulation of fungal cells can survive in the presence of high concentrations of antifungal drugs, which is different from the concepts of antifungal resistance and tolerance.
Rui Wang, Jingnan Lv, Liang Chen, Yanan Zhao, Hong Du   +4 more
doaj   +2 more sources

Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes.

PLoS Pathogens, 2014
The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis, causing infections ranging from superficial to life-threatening disseminated disease. The inherent tolerance of C.
Tobias Schwarzmüller, Biao Ma, Ekkehard Hiller, Fabian Istel, Michael Tscherner, Sascha Brunke, Lauren Ames, Arnaud Firon, Brian Green, Vitor Cabral, Marina Marcet-Houben, Ilse D Jacobsen, Jessica Quintin, Katja Seider, Ingrid Frohner, Walter Glaser, Helmut Jungwirth, Sophie Bachellier-Bassi, Murielle Chauvel, Ute Zeidler, Dominique Ferrandon, Toni Gabaldón, Bernhard Hube, Christophe d'Enfert, Steffen Rupp, Brendan Cormack, Ken Haynes, Karl Kuchler   +27 more
doaj   +6 more sources

Cryptococcus neoformans Mar1 function links mitochondrial metabolism, oxidative stress, and antifungal tolerance. [PDF]

Front Physiol, 2023
Introduction: Microbial pathogens undergo significant physiological changes during interactions with the infected host, including alterations in metabolism and cell architecture. The Cryptococcus neoformans Mar1 protein is required for the proper ordering of the fungal cell wall in response to host-relevant stresses.
Telzrow CL, Esher Righi S, Cathey JM, Granek JA, Alspaugh JA.   +4 more
europepmc   +4 more sources

Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance. [PDF]

Molecules, 2017
Disruption of fungal cell wall should be an effective intervention strategy. However, the cell wall-disrupting echinocandin drugs, such as caspofungin (CAS), cannot exterminate filamentous fungal pathogens during treatment. For potency improvement of cell wall-disrupting agents (CAS, octyl gallate (OG)), antifungal efficacy of thirty-three cinnamic ...
Kim JH, Chan KL, Cheng LW.
europepmc   +5 more sources

Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens. [PDF]

Curr Opin Microbiol
Fungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also ...
Yang F, Berman J.
europepmc   +3 more sources

Trichosporon asahii and Trichosporon inkin Biofilms Produce Antifungal-Tolerant Persister Cells [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Persister cells are metabolically inactive dormant cells that lie within microbial biofilms. They are phenotypic variants highly tolerant to antimicrobials and, therefore, associated with recalcitrant infections. In the present study, we investigated ifTrichosporon asahiiandT. inkinare able to produce persister cells.Trichosporonspp.
Rossana de Aguiar Cordeiro, Ana Luiza Ribeiro Aguiar, Bruno Nascimento da Silva, Lívia Maria Galdino Pereira, Fernando Victor Monteiro Portela, Zoilo Pires de Camargo, Reginaldo Gonçalves de Lima-Neto, Débora de Souza Collares Maia Castelo-Branco, Marcos Fábio Gadelha Rocha, Marcos Fábio Gadelha Rocha, José Júlio Costa Sidrim   +10 more
openaire   +3 more sources

Multifactorial Mechanisms of Tolerance to Ketoconazole in Candida albicans

Microbiology Spectrum, 2021
Candida albicans is a prevalent opportunistic human fungal pathogen for which treatment is limited to only four main classes of antifungal drugs, with the azole and echinocandin classes being used most frequently.
Yi Xu, Hui Lu, Shuo Zhu, Wan-Qian Li, Yuan-ying Jiang, Judith Berman, Feng Yang   +6 more
doaj   +1 more source