Candida albicans Biofilms, Heterogeneity and Antifungal Drug Tolerance [PDF]
The Open Mycology Journal, 2011 Candida albicans is a pathogenic member of the human oral and gastrointestinal microbiota. Biofilms of C. albicans form on indwelling devices, such as catheters and heart valves, and recent evidence suggests that biofilms also form on the mucosal surfaces of the mouth and vagina.
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Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy [PDF]
Eukaryotic Cell, 2011 ABSTRACT Recently, mitochondria have been identified as important contributors to the virulence and drug tolerance of human fungal pathogens. In different scenarios, either hypo- or hypervirulence can result from changes in mitochondrial function.
Miguel, Shingu-Vazquez, Ana, Traven
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Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 [PDF]
, 2017 We thank Zhen-Yuan Lin for help in the preparation of the AP-MS samples, and Cathy Collins for technical assistance. MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), LEC is supported by a Canada Research Chair in ...
Bohovych, Iryna +7 more
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Overexpression of Yeast YLR177w gene provides tolerance to antifungal drug Tioconazole
Annals of Medical Research, 2022 Aim: To find genes that provide resistance to antifungal drug tioconazole by a genomic screening approach. Materials and Methods: Wild-type yeast (BY4741) cells were transformed with a high copy genomic DNA expression library and transformants that can grow on toxic levels of Tioconazole were determined.
Salman Ko +3 more
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Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence [PDF]
, 2010 Peer reviewedPublisher ...
Epp, Elias +10 more
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Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients [PDF]
FEBS Letters, 1995 Azole antifungal compounds are important in the treatment of Cryptococcosis, a major cause of mortality in AIDS patients. The target of the azole drugs is P450 mediated sterol 14α‐demethylase. We have investigated the P450 system of Cryptococcus neoformans with respect to azole tolerance observed in clinical isolates which were obtained following the ...
Lamb, D.C. +4 more
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mBio, 2023 Zinc cluster transcription factors (Zcfs) encoding zcf genes are exclusive for fungi and required for multiple cellular processes including metabolism and development.
Christoph Sasse +13 more
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Biocatalytic preparation and absolute configuration of enantiomerically pure fungistatic anti-2-benzylindane derivatives. Study of the detoxification mechanism by Botrytis cinerea [PDF]
, 2010 Enantiomerically pure 2-benzylindane derivatives were prepared using biocatalytic methods and their absolute configuration determined. (1R,2S)-2-Benzylindan-1-ol ((1R,2S)-2) and (S)-2-benzylindan-1-one ((S)-3) were produced by fermenting baker’s yeast.
Aleu +23 more
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Frontiers in Cellular and Infection MicrobiologyAntifungal resistance and antifungal tolerance are two distinct terms that describe different cellular responses to drugs. Antifungal resistance describes the ability of a fungus to grow above the minimal inhibitory concentration (MIC) of a drug ...
Liangsheng Guo +6 more
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Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus
Frontiers in Microbiology, 2018 Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized structures present in nails, skin, and hair, causing superficial infections known as dermatophytosis.
Nilce M. Martinez-Rossi +8 more
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