Results 51 to 60 of about 2,473,811 (360)

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells

Frontiers in Immunology, 2018
Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies
F. Lichtenegger, M. Rothe, Frauke M. Schnorfeil, Katrin Deiser, Christina Krupka, C. Augsberger, M. Schlüter, Julia S. Neitz, M. Subklewe   +8 more
semanticscholar   +1 more source

Potential use of [gammadelta] T cell-based vaccines in cancer immunotherapy

Frontiers in Immunology, 2014
Immunotherapy is a fast advancing methodology involving one of two approaches: 1) compounds targeting immune checkpoints, and 2) cellular immunomodulators.
Mohd Wajid A. Khan, Matthias eEberl, Bernhard eMoser   +2 more
doaj   +1 more source

Tractions and stress fibers control cell shape and rearrangements in collective cell migration [PDF]

Phys. Rev. X 10, 011016 (2020), 2019
Key to collective cell migration is the ability of cells to rearrange their position with respect to their neighbors. Recent theory and experiments demonstrated that cellular rearrangements are facilitated by cell shape, with cells having more elongated shapes and greater perimeters more easily sliding past their neighbors within the cell layer. Though
arxiv   +1 more source

Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

Nature Communications, 2017
The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen ...
Yikun Yao, Siyuan Chen, Mengtao Cao, Xing Fan, T. Yang, Yin Huang, Xinyang Song, Yongqin Li, L. Ye, N. Shen, Yufang Shi, Xiaoxia Li, Feng Wang, Youcun Qian   +13 more
semanticscholar   +1 more source

Characterization of respiratory dendritic cells from equine lung tissues

BMC Veterinary Research, 2017
Background Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. Previous research demonstrated that DCs have strong potential for anti-viral defense in the host.
Yao Lee, Matti Kiupel, Gisela Soboll Hussey   +2 more
doaj   +1 more source

Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice

Frontiers in Immunology, 2022
Activation of T cell responses is essential for effective tumor clearance; however, inducing targeted, potent antigen presentation to stimulate T cell responses remains challenging. We generated Activating Antigen Carriers (AACs) by engineering red blood
Katarina Blagovic, Carolyne K. Smith, Amritha Ramakrishnan, Lindsay Moore, David R. Soto, Zachary Thompson, Adam P. Stockmann, Sonia Kruszelnicki, Akshi Thakkar, Jason Murray, Sebastian Torres, Bersabel Wondimagegnhu, Roslyn Yi, Maisam Dadgar, Abdul M. Paracha, Claire Page, Louise Clear, Omer A. Chaudhry, Melissa Myint, Devin T. Bridgen, Jonathan B. Gilbert, Katherine J. Seidl, Armon Sharei, Scott Loughhead, Howard Bernstein, Defne Yarar   +25 more
doaj   +1 more source

Modulation of Immune Responses by Exosomes Derived from Antigen-Presenting Cells

Clinical Medicine Insights: Pathology, 2016
Exosome-mediated signaling is important in mediating the inflammatory response. To exert their biological or pathophysiological functions in the recipient cells, exosomes deliver a diverse array of biomacromolecules including long and short coding and ...
Botros B. Shenoda, Seena K. Ajit
semanticscholar   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells

Frontiers in Immunology, 2018
Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2).
Julien Cachat, Christine Deffert, Marco Alessandrini, Pascale Roux-Lombard, Audrey Le Gouellec, Audrey Le Gouellec, Marie-José Stasia, Marie-José Stasia, Stéphanie Hugues, Karl-Heinz Krause   +9 more
doaj   +1 more source