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Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells

open access: yesCells, 2021
Gold nanoparticles (AuNPs) have demonstrated outstanding performance in many biomedical applications. Their safety is recognised; however, their effects on the immune system remain ill defined. Antigen-presenting cells (APCs) are immune cells specialised
Arindam K. Dey   +5 more
doaj   +1 more source

The Antigen Presenting Cells Instruct Plasma Cell Differentiation

open access: yesFrontiers in Immunology, 2014
The professional antigen presenting cells (APCs), including many subsets of dendritic cells and macrophages, not only mediate prompt but nonspecific response against microbes, but also bridge the antigen-specific adaptive immune response through antigen ...
Wei eXu, Jacques eBanchereau
doaj   +1 more source

Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials

open access: yesPharmaceutics, 2019
The development of vaccines plays a vital role in the effective control of several fatal diseases. However, effective prophylactic and therapeutic vaccines have yet to be developed for completely curing deadly diseases, such as cancer, malaria, HIV, and ...
Veena Vijayan   +3 more
doaj   +1 more source

Role of B cells as antigen presenting cells

open access: yesFrontiers in Immunology, 2022
B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity.
Ichwaku Rastogi   +5 more
doaj   +1 more source

The production of IL-12β by mononuclear leucocytes of peripheral blood depending on clinical forms of pulmonary tuberculosis

open access: yesБюллетень сибирской медицины, 2012
The aim of this study was to evaluate the level of secretion of IL-12β by mononuclear leukocytes of peripheral blood under infiltrative and disseminated pulmonary tuberculosis.
R. R. Khasanova   +4 more
doaj   +1 more source

Two Distinct Myeloid Subsets at the Term Human Fetal–Maternal Interface

open access: yesFrontiers in Immunology, 2017
During pregnancy, immune cells infiltrate the placenta at different stages of fetal development. NK cells and macrophages are the most predominant cell types.
Maria Laura Costa   +12 more
doaj   +1 more source

Human dendritic cell functional specialization in steady state and inflammation

open access: yesFrontiers in Immunology, 2014
Dendritic cells (DC) represent a heterogeneous population of antigen-presenting cells that are crucial in initiating and shaping immune responses. Although all DC are capable of antigen uptake, processing and presentation to T cells, DC subtypes differ ...
Arjan eBoltjes, Femke eVan Wijk
doaj   +1 more source

Characterization of respiratory dendritic cells from equine lung tissues

open access: yesBMC Veterinary Research, 2017
Background Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. Previous research demonstrated that DCs have strong potential for anti-viral defense in the host.
Yao Lee   +2 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Potential use of [gammadelta] T cell-based vaccines in cancer immunotherapy

open access: yesFrontiers in Immunology, 2014
Immunotherapy is a fast advancing methodology involving one of two approaches: 1) compounds targeting immune checkpoints, and 2) cellular immunomodulators.
Mohd Wajid A. Khan   +2 more
doaj   +1 more source

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