Results 51 to 60 of about 505,925 (298)

The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcεRI and MHC II

BMC Immunology, 2010
Background At present, it is highly controversial whether pure mast cells can serve as antigen presenting cells, and it is not known whether the capacity of antigen presenting function is temporally restricted to a particular subset of differentiated ...
Sun Liangwu, Weng I-Chun, Croft Michael, Yang Ning-Sun, Gong Jian, Liu Fu-Tong, Chen Swey-Shen   +6 more
doaj   +1 more source

Targeting Antigen-Presenting Cells in Multiple Sclerosis Treatment

Applied Sciences, 2021
Multiple sclerosis (MS) is common neurological disease of the central nervous system (CNS) affecting mostly young adults. Despite decades of studies, its etiology and pathogenesis are not fully unraveled and treatment is still insufficient.
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Andrzej Glabinski   +2 more
doaj   +1 more source

Antigen presentation by Langerhans cells [PDF]

Current Opinion in Immunology, 2013
Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response.
Botond Z, Igyártó, Daniel H, Kaplan
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells

Frontiers in Immunology, 2018
Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2).
Julien Cachat, Christine Deffert, Marco Alessandrini, Pascale Roux-Lombard, Audrey Le Gouellec, Audrey Le Gouellec, Marie-José Stasia, Marie-José Stasia, Stéphanie Hugues, Karl-Heinz Krause   +9 more
doaj   +1 more source

Antigen Presentation by Vascular Cells [PDF]

Frontiers in Immunology, 2017
Antigen presentation by cells of the vessel wall may initiate rapid and localized memory immune responses in peripheral tissues. Peptide antigens displayed on major histocompatibility complex (MHC) molecules on the surface of endothelial cells (ECs) can be recognized by T cell receptors on circulating effector memory T cells (TEM), triggering both ...
Jordan S. Pober, Jonathan Merola, Rebecca Liu, Thomas D. Manes   +3 more
openaire   +3 more sources