Results 1 to 10 of about 5,357 (166)

Antigen-Presenting Cells in Psoriasis

Life, 2022
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease.
Dóra Antal, Shahrzad Alimohammadi, Péter Bai, Attila Gábor Szöllősi, Magdolna Szántó   +4 more
doaj   +3 more sources

Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

Frontiers in Immunology, 2016
Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes, Robert A Benson, Marija Bedaj, Marija Bedaj, Pasquale Maffia, Pasquale Maffia   +5 more
doaj   +3 more sources

Stratification of Antigen-presenting Cells within the Normal Cornea

Ophthalmology and Eye Diseases, 2009
The composition and location of professional antigen presenting cells (APC) varies in different mucosal surfaces. The cornea, long considered an immune-privileged tissue devoid of APCs, is now known to host a heterogeneous network of bone marrow-derived ...
Jared E. Knickelbein, Simon C. Watkins, Paul G. McMenamin, Robert L. Hendricks   +3 more
doaj   +2 more sources

Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells [PDF]

Cell Journal, 2023
Objective: Chimeric antigen receptor (CAR) T cell therapy has recently emerged as a promising approach for thetreatment of different types of cancer.
Ali Sayadmanesh, Mohamad Azadbakht, Kheirollah Yari, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Behzad Baradaran, Mohsen Basiri   +7 more
doaj   +1 more source

CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation

Frontiers in Immunology, 2021
Autoimmune uveitis is a sight-threatening ocular inflammatory condition in which the retina and uveal tissues become a target of autoreactive immune cells.
Yoko Okunuki, Steven J. Tabor, May Y. Lee, Kip M. Connor   +3 more
doaj   +1 more source

Comprehensive single-cell analysis reveals novel anergic antigen-presenting cell subtypes in human sepsis

Frontiers in Immunology, 2023
BackgroundSepsis is a life-threatening condition with high mortality. A few studies have emerged utilizing single-cell RNA sequencing (scRNA-seq) to analyze gene expression at the single-cell resolution in sepsis, but a comprehensive high-resolution ...
Tuo Zhang, Guodong Lian, Guodong Lian, Wei Fang, Wei Fang, Lei Tian, Wenhao Ma, Jicheng Zhang, Jicheng Zhang, Zhaoli Meng, Zhaoli Meng, Hongna Yang, Hongna Yang, Chunting Wang, Chunting Wang, Chengguo Wei, Man Chen, Man Chen   +17 more
doaj   +1 more source

Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer

Cells, 2022
Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches.
Enrica Marmonti, Jacqueline Oliva-Ramirez, Cara Haymaker   +2 more
doaj   +1 more source

Daratumumab prevents programmed death ligand‐1 expression on antigen‐presenting cells in de novo multiple myeloma

Cancer Medicine, 2020
Background Daratumumab (Dara), an anti‐CD38 monoclonal antibody, has an immunologic mechanism of action through targeting of CD38 expressing immune cells in patients with multiple myeloma (MM). Furthermore, it was recently shown that CD38 upregulation in
Nicolas Stocker, Béatrice Gaugler, Laure Ricard, Frédéric deVassoigne, Zora Marjanovic, Mohamad Mohty, Florent Malard   +6 more
doaj   +1 more source

Reprogramming Cancer Cells to Antigen-presenting Cells

Bio-Protocol, 2023
Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells ...
Alexandra Ferreira, Olga Zimmermannova, Ilia Kurochkin, Ervin Ascic, Fritiof Åkerström, Carlos- Pereira   +5 more
doaj   +1 more source

Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus

Microbiome, 2023
Background Cervicovaginal inflammation has been linked to negative reproductive health outcomes including the acquisition of HIV, other sexually transmitted infections, and cervical carcinogenesis. While changes to the vaginal microbiome have been linked
Christina Farr Zuend, Alana Lamont, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah Mutch, Alicia R. Berard, John J. Schellenberg, Faruk Senturk, Stuart McCorrister, Garrett Westmacott, Fran Mulhall, Bonnie Sandberg, Adelicia Yu, Margaret Burnett, Vanessa Poliquin, Adam D. Burgener   +20 more
doaj   +1 more source