Results 61 to 70 of about 497,334 (328)

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Eicosanoid control over antigen presenting cells in asthma [PDF]

, 2018
Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that ...
Adelroth, Aliberti, Angeli, Baratelli, Barnes, Barnig, Barrett, Barrett, Betz, Bhattacharya, Blaho, Boniface, Bourdonnay, Brash, Cai, Chang, Chen, Clarke, de, de, Doherty, Draijer, Dullaers, Dwyer, Everts, Fajt, Fedyk, Funk, Gao, Gao, Gauvreau, George, Giannattasio, Goodarzi, Guilliams, Guilliams, Hajek, Hallstrand, Hallstrand, Hamilton, Hammad, Hammad, Hammad, Hammad, Hammad, Hardy, Harizi, Harizi, Harizi, Hattori, Haworth, Hedi, Henderson, Herrerias, Hilkens, Hirai, Huang, Hunter, Idzko, Jaffar, Jaffar, Jandl, Johnston, Kalinski, Kalinski, Kalinski, Kanaoka, Kay, Khare, Khayrullina, Kolodsick, Kool, Kühn, Lambrecht, Lambrecht, Lambrecht, Lamoureux, Lauzon-Joset, Lee, Legler, Leigh, Levy, Levy, Levy, Levy, Levy, Linton, Liu, Lombardi, Lukic, Lundequist, Lynch, Machida, Maher, Manning, Maric, Medoff, Mirchandani, Miyahara, Mori, Murn, Muñoz, Nagao, Nagata, Nakano, Nataraj, Norimoto, Nothacker, Ohta, Okunishi, Oliphant, Oriss, Parameswaran, Pavord, Peters-Golden, Pettipher, Phythian-Adams, Planagumà, Plantinga, Prinz, Raymond, Rieser, Rieser, Robbiani, Rodríguez-Pinto, Rogerio, Roper, Roper, Roper, Rubio, Salimi, Samuchiwal, Samuchiwal, Scandella, Schlitzer, Schuijs, Semmrich, Serhan, Sestini, Sheibanie, Shiraishi, Shirey, Shirey, Snijdewint, Speth, Steinbrink, Sturm, Szczeklik, Tager, Tanaka, Tang, Tang, Tang, Terawaki, Thornton, Tilley, Torres, Torres, Upham, van, van, van, van, van, Vassiliou, Vieira, Walker, Wenzel, Westphalen, Willart, Williams, Xue, Yamabayashi, Yamaguchi, Yamaoka, Yang, Zasłona, Zasłona, Zhou, Zhou, Çelik   +180 more
core   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Influenza and memory T cells : how to awake the force [PDF]

, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen, Hartshorn, Hufford, Jin, Jordan, Luo, Mosmann, Razvi, Topham, Topham, Topham, Von Andrian, Wijburg   +12 more
core   +3 more sources

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Early signaling defects in human T cells anergized by T cell presentation of autoantigen. [PDF]

, 1992
Major histocompatibility complex class II-positive human T cell clones are nontraditional antigen-presenting cells (APCs) that are able to simultaneously present and respond to peptide or degraded antigen, but are unable to process intact protein ...
Freeman, GJ, Hafler, DA, LaSalle, JM, Nadler, LM, Tolentino, PJ   +4 more
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source