To respond or not to respond - a personal perspective of intestinal tolerance [PDF]
, 2018 For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka +142 more
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Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. II. Chronic Antigen Presentation Overrules Antigen-Presenting B Cell Activation [PDF]
The Journal of Immunology, 2006 Abstract Ag presentation in the absence of danger signals and Ag persistence are the inductive processes of peripheral T cell tolerization proposed so far. Nevertheless, it has never been definitively shown that chronic Ag presentation per se can induce T cell tolerance independent of the state of activation of APCs. In the present work,
Raimondi, G +4 more
openaire +2 more sources
ETEC colonisation factors disrupt the antigen presenting capacity of porcine intestinal dendritic cells [PDF]
, 2012 Enterotoxigenic E. coli (ETEC) are not only a major cause of diarrhoea in travellers to and children in developing countries, but also cause neonatal and postweaning diarrhoea in piglets, leading to a reduced feed conversion and a higher mortality rate ...
Baert, Kim, Devriendt, Bert, Luo, Yu
core
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. [PDF]
, 2009 Subcapsular sinus (SCS) macrophages capture antigens from lymph and present them intact for B cell encounter and follicular delivery. However, the properties of SCS macrophages are poorly defined.
Cyster, Jason G +4 more
core
Mesenchymal stromal cells 2.0: thinking outside the box
Frontiers in ImmunologyMesenchymal stromal cells (MSCs) are non-hematopoietic progenitor cells that can be derived from a variety of sources including bone marrow and adipose tissues among others.
Gabrielle A. Mandl +9 more
doaj +1 more source
Targeted DNA vaccines for enhanced induction of Idiotype (Id)-specific B and T cells
Frontiers in Oncology, 2012 Background: Idiotopes (Id) are antigenic determinants localized in variable (V) regions of Ig. Id-specific T and B cells (antibodies) play a role in immunotherapy of Id+ tumors.
Agnete Brunsvik Fredriksen +2 more
doaj +1 more source
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. [PDF]
, 2018 Tissue-specific autoimmunity occurs when selected antigens presented by susceptible alleles of the major histocompatibility complex are recognized by T cells.
Anderson, Mark S +8 more
core
Antigen Presenting Cells [PDF]
, 2005 Preface. List of Contributors. List of Abbreviations. Color Plates. Part I: Antigen Presentation in the Immune System. 1 Some Old and Some New Findings on Antigen Processing and Presentation (Emil R. Unanue). 1.1 Introduction. 1.2 HEL Processing. 1.3 Selection of Peptide Segments of HEL. 1.4 HEL: Conformational Isomers.
openaire +1 more source
Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines [PDF]
, 2015 B-cells are promising candidate autologous antigen-presenting cells (APCs) to prime antigen-specific T-cells both in vitro and in vivo. However to date, a significant barrier to utilizing B-cells as APCs is their low capacity for non-specific antigen ...
Alejandro, Brian +13 more
core +1 more source
Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]
, 1991 Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Braciale +36 more
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