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Antigen Presentation in the Lung

Frontiers in Immunology, 2022
The lungs are constantly exposed to environmental and infectious agents such as dust, viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped with an immune defense mechanism that involves a wide variety of immunological
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
doaj   +4 more sources

Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]

Frontiers in Immunology, 2016
Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes, Robert A Benson, Marija Bedaj, Marija Bedaj, Pasquale Maffia, Pasquale Maffia   +5 more
doaj   +10 more sources

Antigen Cross-Presentation by Macrophages [PDF]

Frontiers in Immunology, 2020
The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has been recognized widely.
Elke M. Muntjewerff, Luca D. Meesters, Geert van den Bogaart, Geert van den Bogaart   +3 more
doaj   +6 more sources

Antigen Presentation by Vascular Cells [PDF]

Frontiers in Immunology, 2017
Antigen presentation by cells of the vessel wall may initiate rapid and localized memory immune responses in peripheral tissues. Peptide antigens displayed on major histocompatibility complex (MHC) molecules on the surface of endothelial cells (ECs) can ...
Jordan S. Pober, Jonathan Merola, Rebecca Liu, Thomas D. Manes   +3 more
doaj   +5 more sources

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Frontiers in Immunology, 2021
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface.
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock   +2 more
doaj   +2 more sources

Regulation of T cell expansion by antigen presentation dynamics [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Antigen-specific T cells proliferate multiple times during an immune reaction to fight against disease. This expansion of T cells must be carefully regulated to ensure an effective defense while avoiding autoimmunity.
A. Mayer, Yaojun Zhang, A. Perelson, N. Wingreen   +3 more
semanticscholar   +3 more sources

Antigen cross-presentation of immune complexes [PDF]

Frontiers in Immunology, 2014
The ability of dendritic cells (DC) to cross-present tumor antigens has long been a focus of interest of physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway
Barbara ePlatzer, Madeleine Monique Stout, Edda eFiebiger   +2 more
doaj   +4 more sources

CXCL16 knockout inhibit asthma airway inflammation by suppressing H2-DM molecular mediated antigen presentation [PDF]

Cell Death Discovery
The inflammatory microenvironment influences dendritic cell-mediated antigen presentation to regulate asthma Th2 inflammation. The scavenger receptor is expressed on DCs and regulates antigen presentation and T priming. However, whether the transmembrane
Ting-ting Liu, Zhi Zhang, Jing Deng, Chang-yu Shi, Shuai Zheng, Li-xin Jia, Jie Du, Chunmei Piao   +7 more
doaj   +2 more sources

In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei

Vaccines, 2021
Murine dendritic cells, when pulsed with heat-killed Burkholderia pseudomallei and used to immunise naïve mice, have previously been shown to induce protective immunity in vivo. We have now demonstrated the in vitro priming of naïve human T cells against
Durga Reddi, Lydia Durant, David Bernardo, Alistair Noble, Nicholas R. English, Philip Hendy, Graeme C. Clark, Joann L. Prior, Ethel Diane Williamson, Stella C. Knight   +9 more
doaj   +1 more source

Cancer immune escape: the role of antigen presentation machinery

Journal of Cancer Research and Clinical Oncology, 2023
The mechanisms of antigen processing and presentation play a crucial role in the recognition and targeting of cancer cells by the immune system.
Anoop Kallingal, Mateusz Olszewski, Natalia Maciejewska, W. Brankiewicz, M. Bagiński   +4 more
semanticscholar   +1 more source