Results 11 to 20 of about 3,313,044 (282)

Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

npj Vaccines, 2021
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the pandemic. Several of them have reached market authorization and mass production, leading to their global application on a large scale.
F. Heinz, K. Stiasny
semanticscholar   +1 more source

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation.

Journal of Clinical Investigation, 2021
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery.
Hanchen Xu, Kevin Van der Jeught, Zhuolong Zhou, Lu Zhang, Tao Yu, Yifan Sun, Yujing Li, Changlin Wan, K. So, Degang Liu, Michael Frieden, Yuanzhang Fang, A. Mosley, Xiaoming He, Xinna Zhang, G. Sandusky, Yunlong Liu, S. Meroueh, Chi Zhang, A. Wijeratne, Cheng Huang, Guang Ji, Xiongbin Lu   +22 more
semanticscholar   +1 more source

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Nucleic Acids Res., 2020
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses.
Birkir Reynisson, Bruno Alvarez, S. Paul, Bjoern Peters, M. Nielsen   +4 more
semanticscholar   +1 more source

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

Nature Cancer, 2021
Inactivating mutations in LKB1/STK11 are present in roughly 20% of nonsmall cell lung cancers (NSCLC) and portend poor response to anti-PD-1 immunotherapy. Unexpectedly, we found that LKB1 deficiency correlated with elevated tumor mutational burden (TMB)
Jiehui Deng, A. Thennavan, Igor Dolgalev, Ting Chen, Jie Li, Antonio Marzio, J. Poirier, D. Peng, M. Bulatovic, Subhadip Mukhopadhyay, Heather Silver, E. Papadopoulos, V. Pyon, C. Thakurdin, Han Han, Fei Li, Shuai Li, Hailin Ding, Hai Hu, Yuanwang Pan, Vajira Kaushalya Weerasekara, Baishan Jiang, Eric S. Wang, Ian M Ahearn, M. Philips, T. Papagiannakopoulos, A. Tsirigos, E. Rothenberg, J. Gainor, G. Freeman, C. Rudin, N. Gray, P. Hammerman, M. Pagano, J. Heymach, C. Perou, N. Bardeesy, Kwok-kin Wong   +37 more
semanticscholar   +1 more source

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Microbiome, 2020
Background Bacteroides thetaiotaomicron (Bt) is a prominent member of the human intestinal microbiota that, like all gram-negative bacteria, naturally generates nanosized outer membrane vesicles (OMVs) which bud off from the cell surface.
Lydia Durant, Régis Stentz, Alistair Noble, Johanne Brooks, Nadezhda Gicheva, Durga Reddi, Matthew J. O’Connor, Lesley Hoyles, Anne L. McCartney, Ripple Man, E. Tobias Pring, Stella Dilke, Philip Hendy, Jonathan P. Segal, Dennis N. F. Lim, Ravi Misra, Ailsa L. Hart, Naila Arebi, Simon R. Carding, Stella C. Knight   +19 more
doaj   +1 more source

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

Frontiers in Genetics, 2020
The CD69 gene encodes a C-type lectin glycoprotein with immune regulatory properties which is expressed on the cell surfaces of all activated hematopoietic cells.
Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica   +6 more
doaj   +1 more source

Protein-based antigen presentation platforms for nanoparticle vaccines

npj Vaccines, 2021
Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response.
B. Nguyen, N. Tolia
semanticscholar   +1 more source

Antigen Stability Controls Antigen Presentation [PDF]

Journal of Biological Chemistry, 2004
We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Robert, Thai, Gervaise, Moine, Michel, Desmadril, Denis, Servent, Jean-Luc, Tarride, André, Ménez, Michel, Léonetti   +6 more
openaire   +2 more sources

Tumor Antigen Presentation by Dermal Antigen-Presenting Cells [PDF]

Journal of Investigative Dermatology, 2000
Several phenotypes of antigen-presenting cells are present in the dermis, where they presumably function to present encountered antigens for immune responses. This study examined the ability of dermal antigen-presenting cells to present tumor-associated antigens for the induction of in vivo antitumor immunity.
Campton, Kristina, Ding, Wanhong, Yan, Zengmin, Ozawa, Hiroaki, Seiffert, Kristina, Miranda, Edward, Granstein, Richard D., Lonati, Antonietta, Beissert, Stefan   +8 more
openaire   +2 more sources

Direct antigen presentation is the canonical pathway of cytomegalovirus CD8 T-cell priming regulated by balanced immune evasion ensuring a strong antiviral response

Frontiers in Immunology, 2023
CD8 T cells are important antiviral effectors in the adaptive immune response to cytomegaloviruses (CMV). Naïve CD8 T cells can be primed by professional antigen-presenting cells (pAPCs) alternatively by “direct antigen presentation” or “antigen cross ...
Julia K. Büttner, Sara Becker, Annette Fink, Melanie M. Brinkmann, Melanie M. Brinkmann, Rafaela Holtappels, Matthias J. Reddehase, Niels A. Lemmermann, Niels A. Lemmermann   +8 more
doaj   +1 more source