Results 11 to 20 of about 2,990,849 (376)

Antigen Presentation in the Gut [PDF]

Canadian Journal of Gastroenterology, 1990
The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells.
W Doe, P Pavli
doaj   +2 more sources

Antigen Presentation the Macrophage Way [PDF]

Cell, 2007
Multiphoton intravital microscopy of lymph nodes has revolutionized the study of the early events leading to induction of acquired immunity. Using this technique, Junt et al.
Santos, Luciana dos, Jacoby, Thalita Silva, Ness, Sandro Luis Ribeiro, Guerra, Gerson, Wayhs, Carlos Alberto Yasin   +4 more
core   +5 more sources

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells. [PDF]

Annual Review of Immunology, 2018
The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs).
Marthe F. S. Lindenbergh, W. Stoorvogel
semanticscholar   +3 more sources

Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer Models

Frontiers in Immunology, 2021
Although T cell-recruiting CD3-binding bispecific antibodies (BiMAb) have been proven to be clinically effective for hematologic malignancies, the success of BiMAb targeting solid tumor-associated antigens (TAA) in carcinomas so far remains poor.
Karsten M. Warwas, Karsten M. Warwas, Marten Meyer, Marten Meyer, Márcia Gonçalves, Márcia Gonçalves, Gerhard Moldenhauer, Nadja Bulbuc, Susanne Knabe, Claudia Luckner-Minden, Claudia Ziegelmeier, Claus Peter Heussel, Claus Peter Heussel, Claus Peter Heussel, Inka Zörnig, Dirk Jäger, Dirk Jäger, Frank Momburg, Frank Momburg   +18 more
doaj   +1 more source

Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

npj Vaccines, 2021
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the pandemic. Several of them have reached market authorization and mass production, leading to their global application on a large scale.
F. Heinz, K. Stiasny
semanticscholar   +1 more source

Tumor Antigen Presentation by Dermal Antigen-Presenting Cells [PDF]

Journal of Investigative Dermatology, 2000
Several phenotypes of antigen-presenting cells are present in the dermis, where they presumably function to present encountered antigens for immune responses. This study examined the ability of dermal antigen-presenting cells to present tumor-associated antigens for the induction of in vivo antitumor immunity.
Edward Miranda, A. Lonati, H. Ozawa, Richard D. Granstein, Kristina Seiffert, Wanhong Ding, Stefan Beissert, Kristina Campton, Zengmin Yan   +8 more
openaire   +3 more sources

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Microbiome, 2020
Background Bacteroides thetaiotaomicron (Bt) is a prominent member of the human intestinal microbiota that, like all gram-negative bacteria, naturally generates nanosized outer membrane vesicles (OMVs) which bud off from the cell surface.
Lydia Durant, Régis Stentz, Alistair Noble, Johanne Brooks, Nadezhda Gicheva, Durga Reddi, Matthew J. O’Connor, Lesley Hoyles, Anne L. McCartney, Ripple Man, E. Tobias Pring, Stella Dilke, Philip Hendy, Jonathan P. Segal, Dennis N. F. Lim, Ravi Misra, Ailsa L. Hart, Naila Arebi, Simon R. Carding, Stella C. Knight   +19 more
doaj   +1 more source

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Nucleic Acids Res., 2020
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses.
Birkir Reynisson, Bruno Alvarez, S. Paul, Bjoern Peters, M. Nielsen   +4 more
semanticscholar   +1 more source

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation.

Journal of Clinical Investigation, 2021
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery.
Hanchen Xu, Kevin Van der Jeught, Zhuolong Zhou, Lu Zhang, Tao Yu, Yifan Sun, Yujing Li, Changlin Wan, K. So, Degang Liu, Michael Frieden, Yuanzhang Fang, A. Mosley, Xiaoming He, Xinna Zhang, G. Sandusky, Yunlong Liu, S. Meroueh, Chi Zhang, A. Wijeratne, Cheng Huang, G. Ji, Xiongbin Lu   +22 more
semanticscholar   +1 more source

Protein-based antigen presentation platforms for nanoparticle vaccines

npj Vaccines, 2021
Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response.
B. Nguyen, N. Tolia
semanticscholar   +1 more source