Results 11 to 20 of about 3,190,099 (375)

Antigen Presentation in the Gut [PDF]

Canadian Journal of Gastroenterology, 1990
The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells.
W Doe, P Pavli
doaj   +2 more sources

In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei

Vaccines, 2021
Murine dendritic cells, when pulsed with heat-killed Burkholderia pseudomallei and used to immunise naïve mice, have previously been shown to induce protective immunity in vivo. We have now demonstrated the in vitro priming of naïve human T cells against
Durga Reddi, Lydia Durant, David Bernardo, Alistair Noble, Nicholas R. English, Philip Hendy, Graeme C. Clark, Joann L. Prior, Ethel Diane Williamson, Stella C. Knight   +9 more
doaj   +1 more source

Cancer immune escape: the role of antigen presentation machinery

Journal of Cancer Research and Clinical Oncology, 2023
The mechanisms of antigen processing and presentation play a crucial role in the recognition and targeting of cancer cells by the immune system.
Anoop Kallingal, Mateusz Olszewski, Natalia Maciejewska, W. Brankiewicz, M. Bagiński   +4 more
semanticscholar   +1 more source

Antigen presentation in uveitis [PDF]

Eye, 1997
Experimental autoimmune uveoretinits (EAU) is not only a valuable model for human inflammatory eye diseases, it is also a useful system for studying many aspects of immunobiology. One such aspect is self/non-self discrimination, the ability of the immune system to tolerate self molecules while responding aggressively to foreign antigens. Our laboratory
Shiv A. Prasad, Dale S. Gregerson
openalex   +4 more sources

Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer Models

Frontiers in Immunology, 2021
Although T cell-recruiting CD3-binding bispecific antibodies (BiMAb) have been proven to be clinically effective for hematologic malignancies, the success of BiMAb targeting solid tumor-associated antigens (TAA) in carcinomas so far remains poor.
Karsten M. Warwas, Karsten M. Warwas, Marten Meyer, Marten Meyer, Márcia Gonçalves, Márcia Gonçalves, Gerhard Moldenhauer, Nadja Bulbuc, Susanne Knabe, Claudia Luckner-Minden, Claudia Ziegelmeier, Claus Peter Heussel, Claus Peter Heussel, Claus Peter Heussel, Inka Zörnig, Dirk Jäger, Dirk Jäger, Frank Momburg, Frank Momburg   +18 more
doaj   +1 more source

Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

npj Vaccines, 2021
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the pandemic. Several of them have reached market authorization and mass production, leading to their global application on a large scale.
F. Heinz, K. Stiasny
semanticscholar   +1 more source

Tumor Antigen Presentation by Dermal Antigen-Presenting Cells [PDF]

Journal of Investigative Dermatology, 2000
Several phenotypes of antigen-presenting cells are present in the dermis, where they presumably function to present encountered antigens for immune responses. This study examined the ability of dermal antigen-presenting cells to present tumor-associated antigens for the induction of in vivo antitumor immunity.
Edward Miranda, A. Lonati, H. Ozawa, Richard D. Granstein, Kristina Seiffert, Wanhong Ding, Stefan Beissert, Kristina Campton, Zengmin Yan   +8 more
openaire   +3 more sources

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Nucleic Acids Res., 2020
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses.
Birkir Reynisson, Bruno Alvarez, S. Paul, Bjoern Peters, M. Nielsen   +4 more
semanticscholar   +1 more source

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation.

Journal of Clinical Investigation, 2021
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery.
Hanchen Xu, Kevin Van der Jeught, Zhuolong Zhou, Lu Zhang, Tao Yu, Yifan Sun, Yujing Li, Changlin Wan, K. So, Degang Liu, Michael Frieden, Yuanzhang Fang, A. Mosley, Xiaoming He, Xinna Zhang, G. Sandusky, Yunlong Liu, S. Meroueh, Chi Zhang, A. Wijeratne, Cheng Huang, G. Ji, Xiongbin Lu   +22 more
semanticscholar   +1 more source

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Microbiome, 2020
Background Bacteroides thetaiotaomicron (Bt) is a prominent member of the human intestinal microbiota that, like all gram-negative bacteria, naturally generates nanosized outer membrane vesicles (OMVs) which bud off from the cell surface.
Lydia Durant, Régis Stentz, Alistair Noble, Johanne Brooks, Nadezhda Gicheva, Durga Reddi, Matthew J. O’Connor, Lesley Hoyles, Anne L. McCartney, Ripple Man, E. Tobias Pring, Stella Dilke, Philip Hendy, Jonathan P. Segal, Dennis N. F. Lim, Ravi Misra, Ailsa L. Hart, Naila Arebi, Simon R. Carding, Stella C. Knight   +19 more
doaj   +1 more source