Results 11 to 20 of about 3,217,603 (374)

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Frontiers in Immunology, 2021
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface.
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock   +2 more
doaj   +2 more sources

Antigen Cross-Presentation by Macrophages

Frontiers in Immunology, 2020
The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has been recognized widely.
Elke M. Muntjewerff, Luca D. Meesters, Geert van den Bogaart, Geert van den Bogaart   +3 more
doaj   +2 more sources

Antigen Presentation by Vascular Cells

Frontiers in Immunology, 2017
Antigen presentation by cells of the vessel wall may initiate rapid and localized memory immune responses in peripheral tissues. Peptide antigens displayed on major histocompatibility complex (MHC) molecules on the surface of endothelial cells (ECs) can ...
Jordan S. Pober, Jonathan Merola, Rebecca Liu, Thomas D. Manes   +3 more
doaj   +2 more sources

Regulation of T cell expansion by antigen presentation dynamics [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells.
Mayer, Andreas, Perelson, Alan S., Wingreen, Ned S., Zhang, Yaojun   +3 more
core   +2 more sources

Cancer immune escape: the role of antigen presentation machinery

Journal of Cancer Research and Clinical Oncology, 2023
The mechanisms of antigen processing and presentation play a crucial role in the recognition and targeting of cancer cells by the immune system.
Anoop Kallingal, Mateusz Olszewski, Natalia Maciejewska, W. Brankiewicz, M. Bagiński   +4 more
semanticscholar   +1 more source

Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

npj Vaccines, 2021
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the pandemic. Several of them have reached market authorization and mass production, leading to their global application on a large scale.
F. Heinz, K. Stiasny
semanticscholar   +1 more source

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Nucleic Acids Res., 2020
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses.
Birkir Reynisson, Bruno Alvarez, S. Paul, Bjoern Peters, M. Nielsen   +4 more
semanticscholar   +1 more source

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation.

Journal of Clinical Investigation, 2021
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery.
Hanchen Xu, Kevin Van der Jeught, Zhuolong Zhou, Lu Zhang, Tao Yu, Yifan Sun, Yujing Li, Changlin Wan, K. So, Degang Liu, Michael Frieden, Yuanzhang Fang, A. Mosley, Xiaoming He, Xinna Zhang, G. Sandusky, Yunlong Liu, S. Meroueh, Chi Zhang, A. Wijeratne, Cheng Huang, G. Ji, Xiongbin Lu   +22 more
semanticscholar   +1 more source

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

Frontiers in Genetics, 2020
The CD69 gene encodes a C-type lectin glycoprotein with immune regulatory properties which is expressed on the cell surfaces of all activated hematopoietic cells.
Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica   +6 more
doaj   +1 more source

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

Nature Cancer, 2021
Inactivating mutations in LKB1/STK11 are present in roughly 20% of nonsmall cell lung cancers (NSCLC) and portend poor response to anti-PD-1 immunotherapy. Unexpectedly, we found that LKB1 deficiency correlated with elevated tumor mutational burden (TMB)
Jiehui Deng, A. Thennavan, Igor Dolgalev, Ting Chen, Jie Li, Antonio Marzio, J. Poirier, D. Peng, M. Bulatovic, Subhadip Mukhopadhyay, Heather Silver, E. Papadopoulos, V. Pyon, C. Thakurdin, Han Han, Fei Li, Shuai Li, Hailin Ding, Hai Hu, Yuanwang Pan, Vajira Kaushalya Weerasekara, Baishan Jiang, Eric S. Wang, Ian M Ahearn, M. Philips, T. Papagiannakopoulos, A. Tsirigos, E. Rothenberg, J. Gainor, G. Freeman, C. Rudin, N. Gray, P. Hammerman, M. Pagano, J. Heymach, C. Perou, N. Bardeesy, Kwok-kin Wong   +37 more
semanticscholar   +1 more source