Results 21 to 30 of about 2,940,827 (187)

Poly(2-propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles as a targeted antigen delivery system to direct either CD4+ or CD8+ T cell activation. [PDF]

, 2017
Poly(lactic-co-glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner.
Bracho-Sanchez, Evelyn, Carstens, Matthew R, Duvall, Craig L, Fernando, Lawrence P, Keselowsky, Benjamin G, Lewis, Jamal S, Yang, Lirong   +6 more
core   +1 more source

Heat Shock Protein Magic in Antigen Trafficking within Dendritic Cells:Implications in Antigen Cross-presentation in Immunity [PDF]

, 2012
Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest them, delivering fragments to the MHC class I pathway to display antigenic peptides to CD8＋ T cells, a process known as cross-presentation.
Udono, Heiichiro
core   +1 more source

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation [PDF]

, 2007
The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1).
Ben J. C. Quah, Christopher R. Parish, Klaus I. Matthaei, Mark D. Hulett, Vaughan P. Barlow, Virginia McPhun   +5 more
core   +2 more sources

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]

, 1992
Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Del Val, Margarita, Hartlaub, Udo, Hengel, Hartmut, Häcker, Hans, Koszinowski, Ulrich H., Lucin, Pero, Ruppert, Thomas   +6 more
core   +2 more sources

A generic polymer-protein ligation strategy for vaccine delivery [PDF]

, 2016
Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens.
De Geest, Bruno, Fierens, Kaat, Lambrecht, Bart, Lybaert, Lien, Nuhn, Lutz, Schuijs, Martijn, Vanparijs, Nane   +6 more
core   +1 more source

Improved prediction of MHC II antigen presentation through integration and motif deconvolution of mass spectrometry MHC eluted ligand data

bioRxiv, 2019
Major Histocompatibility Complex II (MHC II) molecules play a key role in the onset and control of cellular immunity. In a highly selective process, MHC II presents peptides derived from exogenous antigens on the surface of antigen presenting cells for T
Birkir Reynisson, C. Barra, S. Kaabinejadian, W. Hildebrand, Bjoern Peters, M. Nielsen   +5 more
semanticscholar   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]

, 2009
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Bendz, Bendz, Bernhardt, Bernhardt, Calderwood, Calderwood, Carilli, Carilli, Castellino, Castellino, Davis, Davis, Elguindi, Elguindi, Farr, Farr, Fernández, Fernández, Flechtner, Flechtner, Flynn, Flynn, Fourie, Fourie, Germeroth, Germeroth, Gragerov, Gragerov, Hartl, Hartl, Ishii, Ishii, Kawakami, Kawakami, Kelley, Kelley, Knarr, Knarr, Laemmli, Laemmli, Landry, Landry, Mayer, Mayer, Mayer, Mayer, Mayer, Mayer, McCarty, McCarty, Milani, Milani, Moroi, Moroi, Multhoff, Multhoff, Noessner, Noessner, Norby, Norby, Stevens, Stevens, Suto, Suto, Takeda, Takeda, Udono, Udono, Udono, Udono, Ueda, Ueda, Visseren, Visseren, Wegele, Wegele, Wölfel, Wölfel, Zheng, Zheng, Zhu, Zhu   +81 more
core   +1 more source

Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.

, 2002
Malaria sporozoites induce swift activation of antigen-specific CD8(+) T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of ...
A. Morrot, Ahmed, Altman, Bruno, Bru  a-Romero, Busch, Carvalho, Carvalho, Clyde, F. Zavala, G.-i. Sano, Gilbert, Goossens, Gray, Herrington, Hou, J. C. R. Hafalla, Kaech, Kundig, L. H. Carvalho, Lalvani, Lau, Li, Mercado, Mullbacher, Murali-Krishna, Oehen, Oliveira-Ferreira, Plebanski, Plebanski, Renggli, Rodrigues, Rodrigues, Rodrigues, Rodrigues, Romero, Scheller, Schneider, Sedegah, Shinkai, Tanchot, van Stipdonk, Vanderberg, Veiga-Fernandes, Weiss   +44 more
core   +2 more sources

A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules [PDF]

, 2006
The heat shock protein (HSP) Hsp90 is known to chaperone cytosolic peptides for MHC class I (MHCI)-restricted antigen presentation to T lymphocytes. We now demonstrate a role for Hsp90 activity in presentation of antigens on MHCII.
Bal, Vineeta, George, Anna, Mayor, Satyajit, Rajagopal, Deepa, Rath, Satyajit   +4 more
core   +1 more source