Results 21 to 30 of about 3,190,099 (375)

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

Nature Cancer, 2021
Inactivating mutations in LKB1/STK11 are present in roughly 20% of nonsmall cell lung cancers (NSCLC) and portend poor response to anti-PD-1 immunotherapy. Unexpectedly, we found that LKB1 deficiency correlated with elevated tumor mutational burden (TMB)
Jiehui Deng, A. Thennavan, Igor Dolgalev, Ting Chen, Jie Li, Antonio Marzio, J. Poirier, D. Peng, M. Bulatovic, Subhadip Mukhopadhyay, Heather Silver, E. Papadopoulos, V. Pyon, C. Thakurdin, Han Han, Fei Li, Shuai Li, Hailin Ding, Hai Hu, Yuanwang Pan, Vajira Kaushalya Weerasekara, Baishan Jiang, Eric S. Wang, Ian M Ahearn, M. Philips, T. Papagiannakopoulos, A. Tsirigos, E. Rothenberg, J. Gainor, G. Freeman, C. Rudin, N. Gray, P. Hammerman, M. Pagano, J. Heymach, C. Perou, N. Bardeesy, Kwok-kin Wong   +37 more
semanticscholar   +1 more source

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

Frontiers in Genetics, 2020
The CD69 gene encodes a C-type lectin glycoprotein with immune regulatory properties which is expressed on the cell surfaces of all activated hematopoietic cells.
Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica   +6 more
doaj   +1 more source

Protein-based antigen presentation platforms for nanoparticle vaccines

npj Vaccines, 2021
Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response.
B. Nguyen, N. Tolia
semanticscholar   +1 more source

Presentation of hepatocellular antigens [PDF]

Cellular & Molecular Immunology, 2016
The liver is an organ in which antigen-specific T-cell responses manifest a bias toward immune tolerance. This is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general.
Arash Grakoui, Ian N. Crispe
openaire   +3 more sources

An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity

Nature Biomedical Engineering, 2021
In breast cancer, genetic heterogeneity, the lack of actionable targets and immune evasion all contribute to the limited clinical response rates to immune checkpoint blockade therapy.
Zhuolong Zhou, Kevin Van der Jeught, Yuanzhang Fang, Tao Yu, Yujing Li, Zheng Ao, Sheng Liu, Lu Zhang, Yang Yang, Haniyeh Eyvani, M. L. Cox, Xiyu Wang, Xiaoming He, Guang Ji, B. Schneider, Feng Guo, J. Wan, Xinna Zhang, Xiongbin Lu   +18 more
semanticscholar   +1 more source

Pathogenicity of anti-ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura. [PDF]

, 2015
BACKGROUND: Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency.
Crawley, JT, De Groot, R, Scully, MA, Thomas, MR   +3 more
core   +2 more sources

Poly(2-propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles as a targeted antigen delivery system to direct either CD4+ or CD8+ T cell activation. [PDF]

, 2017
Poly(lactic-co-glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner.
Bracho-Sanchez, Evelyn, Carstens, Matthew R, Duvall, Craig L, Fernando, Lawrence P, Keselowsky, Benjamin G, Lewis, Jamal S, Yang, Lirong   +6 more
core   +1 more source

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation [PDF]

, 2007
The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1).
Ben J. C. Quah, Christopher R. Parish, Klaus I. Matthaei, Mark D. Hulett, Vaughan P. Barlow, Virginia McPhun   +5 more
core   +2 more sources

Direct antigen presentation is the canonical pathway of cytomegalovirus CD8 T-cell priming regulated by balanced immune evasion ensuring a strong antiviral response

Frontiers in Immunology, 2023
CD8 T cells are important antiviral effectors in the adaptive immune response to cytomegaloviruses (CMV). Naïve CD8 T cells can be primed by professional antigen-presenting cells (pAPCs) alternatively by “direct antigen presentation” or “antigen cross ...
Julia K. Büttner, Sara Becker, Annette Fink, Melanie M. Brinkmann, Melanie M. Brinkmann, Rafaela Holtappels, Matthias J. Reddehase, Niels A. Lemmermann, Niels A. Lemmermann   +8 more
doaj   +1 more source

Antigen depot is not required for alum adjuvanticity [PDF]

, 2012
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation
Abigail H. Pollock, Brewer J. M., Holt L. B., James M. Brewer, Murphy D. B., Oakley C. L., Paul Garside, Robert A. Benson, Rush C. M., Sharon Hutchison, Vivienne B. Gibson, Ziegler S. F.   +11 more
core   +2 more sources