Results 21 to 30 of about 3,313,044 (282)

Making Antigen Presentable [PDF]

The Journal of Immunology, 2007
In the late 1960s and early 1970s, a shift occurred in the focus of immunological research from Ab-dominated studies to ones involving cellular components of immunity such as T cells, B cells, and APCs.
openaire   +2 more sources

Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal ColonSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Most knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103+ DC specialize in generating immune tolerance with the functionality of CD11b+/− subsets being unclear.
David Bernardo, Lydia Durant, Elizabeth R. Mann, Elizabeth Bassity, Enrique Montalvillo, Ripple Man, Rakesh Vora, Durga Reddi, Fahri Bayiroglu, Luis Fernández-Salazar, Nick R. English, Simon T.C. Peake, Jon Landy, Gui H. Lee, George Malietzis, Yi Harn Siaw, Aravinth U. Murugananthan, Phil Hendy, Eva Sánchez-Recio, Robin K.S. Phillips, Jose A. Garrote, Paul Scott, Julian Parkhill, Malte Paulsen, Ailsa L. Hart, Hafid O. Al-Hassi, Eduardo Arranz, Alan W. Walker, Simon R. Carding, Stella C. Knight   +29 more
doaj   +1 more source

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

Journal of Experimental Medicine, 1994
Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic ...
F. Sallusto, A. Lanzavecchia
semanticscholar   +1 more source

Chemotherapy enhances cross-presentation of nuclear tumor antigens. [PDF]

PLoS ONE, 2014
Cross-presentation of tumor antigen is essential for efficient priming of naïve CD8⁺ T lymphocytes and induction of effective anti-tumor immunity. We hypothesized that the subcellular location of a tumor antigen could affect the efficiency of cross ...
Chidozie C Anyaegbu, Richard A Lake, Kathy Heel, Bruce W Robinson, Scott A Fisher   +4 more
doaj   +1 more source

Promising Extracellular Vesicle-Based Vaccines against Viruses, Including SARS-CoV-2

Biology, 2021
Extracellular vesicles (EVs) are secreted from almost all human cells and mediate intercellular communication by transferring heterogeneous molecules (i.e., DNA, RNAs, proteins, and lipids).
Berina Sabanovic, Francesco Piva, Monia Cecati, Matteo Giulietti   +3 more
doaj   +1 more source

Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota

Mediators of Inflammation, 2013
Background. Dendritic cells regulate immune responses to microbial products and play a key role in ulcerative colitis (UC) pathology. We determined the immunomodulatory effects of probiotic strain Lactobacillus casei Shirota (LcS) on human DC
Elizabeth R. Mann, Jialu You, Verena Horneffer-van der Sluis, David Bernardo, Hafid Omar Al-Hassi, Jon Landy, Simon T. Peake, Linda V. Thomas, Cheng T. Tee, Gui Han Lee, Ailsa L. Hart, Parveen Yaqoob, Stella C. Knight   +12 more
doaj   +1 more source

Identification and molecular characterization of oat peptides implicated on coeliac immune response

Food & Nutrition Research, 2016
Background: Oats provide important nutritional and pharmacological properties, although their safety in coeliac patients remains controversial. Previous studies have confirmed that the reactivity of the anti-33-mer monoclonal antibody with different oat ...
Isabel Comino, David Bernardo, Emmanuelle Bancel, María de Lourdes Moreno, Borja Sánchez, Francisco Barro, Tanja Šuligoj, Paul J. Ciclitira, Ángel Cebolla, Stella C. Knight, Gérard Branlard, Carolina Sousa   +11 more
doaj   +1 more source

The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy

Cancers, 2021
Simple Summary A new class of drugs, termed Immune Checkpoint Inhibitors, has revolutionized cancer therapy during the last few years. Unfortunately, these drugs are only effective for a subset of patients and cancer types. Recent work has suggested that
A. Mpakali, E. Stratikos
semanticscholar   +1 more source

HLA-E Peptide Repertoire and Dimorphism—Centerpieces in the Adaptive NK Cell Puzzle?

Frontiers in Immunology, 2018
Adaptive Natural Killer (NK) cells, a heterogenous subpopulation of human NK cells with a unique phenotypic and functional signature, became arguably one of the central areas of interest in the field.
Alexander Rölle, Alexander Rölle, Dirk Jäger, Dirk Jäger, Frank Momburg   +4 more
doaj   +1 more source

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Cancer Cell, 2019
Summary Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates ...
M. Burr, C. Sparbier, K. Chan, Yih-Chih Chan, A. Kersbergen, E. Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C. Bell, O. Gilan, Susan Jackson, L. Tan, S. Wong, Sebastian Hollizeck, Ewa M Michalak, H. Siddle, M. McCabe, R. Prinjha, Glen R Guerra, B. Solomon, S. Sandhu, S. Dawson, P. Beavis, R. Tothill, C. Cullinane, P. Lehner, K. Sutherland, M. Dawson   +27 more
semanticscholar   +1 more source