Results 21 to 30 of about 2,990,849 (376)

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

Frontiers in Genetics, 2020
The CD69 gene encodes a C-type lectin glycoprotein with immune regulatory properties which is expressed on the cell surfaces of all activated hematopoietic cells.
Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica   +6 more
doaj   +1 more source

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

Nature Cancer, 2021
Inactivating mutations in LKB1/STK11 are present in roughly 20% of nonsmall cell lung cancers (NSCLC) and portend poor response to anti-PD-1 immunotherapy. Unexpectedly, we found that LKB1 deficiency correlated with elevated tumor mutational burden (TMB)
Jiehui Deng, A. Thennavan, Igor Dolgalev, Ting Chen, Jie Li, Antonio Marzio, J. Poirier, D. Peng, M. Bulatovic, Subhadip Mukhopadhyay, Heather Silver, E. Papadopoulos, V. Pyon, C. Thakurdin, Han Han, Fei Li, Shuai Li, Hailin Ding, Hai Hu, Yuanwang Pan, Vajira Kaushalya Weerasekara, Baishan Jiang, Eric S. Wang, Ian M Ahearn, M. Philips, T. Papagiannakopoulos, A. Tsirigos, E. Rothenberg, J. Gainor, G. Freeman, C. Rudin, N. Gray, P. Hammerman, M. Pagano, J. Heymach, C. Perou, N. Bardeesy, Kwok-kin Wong   +37 more
semanticscholar   +1 more source

Presentation of hepatocellular antigens [PDF]

Cellular & Molecular Immunology, 2016
The liver is an organ in which antigen-specific T-cell responses manifest a bias toward immune tolerance. This is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general.
Arash Grakoui, Ian N. Crispe
openaire   +3 more sources

Antigen depot is not required for alum adjuvanticity [PDF]

, 2012
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation
Abigail H. Pollock, Brewer J. M., Holt L. B., James M. Brewer, Murphy D. B., Oakley C. L., Paul Garside, Robert A. Benson, Rush C. M., Sharon Hutchison, Vivienne B. Gibson, Ziegler S. F.   +11 more
core   +2 more sources

Chemotherapy enhances cross-presentation of nuclear tumor antigens. [PDF]

PLoS ONE, 2014
Cross-presentation of tumor antigen is essential for efficient priming of naïve CD8⁺ T lymphocytes and induction of effective anti-tumor immunity. We hypothesized that the subcellular location of a tumor antigen could affect the efficiency of cross ...
Chidozie C Anyaegbu, Richard A Lake, Kathy Heel, Bruce W Robinson, Scott A Fisher   +4 more
doaj   +1 more source

Direct antigen presentation is the canonical pathway of cytomegalovirus CD8 T-cell priming regulated by balanced immune evasion ensuring a strong antiviral response

Frontiers in Immunology, 2023
CD8 T cells are important antiviral effectors in the adaptive immune response to cytomegaloviruses (CMV). Naïve CD8 T cells can be primed by professional antigen-presenting cells (pAPCs) alternatively by “direct antigen presentation” or “antigen cross ...
Julia K. Büttner, Sara Becker, Annette Fink, Melanie M. Brinkmann, Melanie M. Brinkmann, Rafaela Holtappels, Matthias J. Reddehase, Niels A. Lemmermann, Niels A. Lemmermann   +8 more
doaj   +1 more source

Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase [PDF]

, 1989
The regulation of antigen processing and presentation to MHC class I-restricted cytolytic T lymphocytes was studied in cells infected with murine cytomegalovirus. Recognition by cytolytic T lymphocytes of the phosphoprotein pp89, the immunodominant viral
Bernards, Borysiewicz, Braciale, Burgert, Cochet, Coupar, De Plaen, Del Val, Ebeling, Germain, Germain, Gooding, Gregory, Haddada, Hansen, Jennings, Jonjic, Keil, Keil, Keil, Konrad Münch, Koszinowski, Koszinowski, Kotwal, Lemke, Lurquin, Margarita Del Val, Maryanski, Masucci, Matthias J. Reddehase, Reddehase, Reddehase, Reddehase, Reddehase, Reddehase, Rice, Schickendanz, Schrier, Schwartz, Shimonkevitz, Stinski, Tanaka, Townsend, Townsend, Townsend, Ulrich H. Koszinowski, Vaessen, Volkmer, Yewdell   +48 more
core   +1 more source

Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars. [PDF]

, 2018
Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars.
Bäumler, Andreas J, Cobb, Brian A, Hiyoshi, Hirotaka, Lock, Gabriel, Raffatellu, Manuela, Saechao, Cheng, Wangdi, Tamding   +6 more
core   +6 more sources

A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation

Science Advances, 2020
A micropeptide encoded by MIR155HG modulates antigen presentation and suppresses autoinflammation through binding to HSC70. Many annotated long noncoding RNAs (lncRNAs) harbor predicted short open reading frames (sORFs), but the coding capacities of ...
Liman Niu, F. Lou, Yang Sun, Libo Sun, Xiaojie Cai, Zhaoyuan Liu, Hong Zhou, Hong Wang, Zhikai Wang, Jing Bai, Q. Yin, Junxun Zhang, Linjiao Chen, Danhong Peng, Zhenyao Xu, Yuanyuan Gao, Sibei Tang, Li Fan, Honglin Wang   +18 more
semanticscholar   +1 more source

Antigen presentation in uveitis [PDF]

Eye, 1997
Experimental autoimmune uveoretinits (EAU) is not only a valuable model for human inflammatory eye diseases, it is also a useful system for studying many aspects of immunobiology. One such aspect is self/non-self discrimination, the ability of the immune system to tolerate self molecules while responding aggressively to foreign antigens. Our laboratory
Shiv A. Prasad, Dale S. Gregerson
openaire   +3 more sources