Results 21 to 30 of about 470,515 (138)

Making Antigen Presentable [PDF]

The Journal of Immunology, 2007
In the late 1960s and early 1970s, a shift occurred in the focus of immunological research from Ab-dominated studies to ones involving cellular components of immunity such as T cells, B cells, and APCs.
openaire   +2 more sources

The Role of FcRn in Antigen Presentation [PDF]

Frontiers in Immunology, 2014
Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to which it binds render this an important immunomodulatory molecule. In addition to the classical Fcγ
Kristi eBaker, Timo eRath, Timo eRath, Michal ePyzik, Richard S. Blumberg   +4 more
openaire   +6 more sources

A generic polymer-protein ligation strategy for vaccine delivery [PDF]

, 2016
Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens.
De Geest, Bruno, Fierens, Kaat, Lambrecht, Bart, Lybaert, Lien, Nuhn, Lutz, Schuijs, Martijn, Vanparijs, Nane   +6 more
core   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]

, 2009
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Bendz, Bendz, Bernhardt, Bernhardt, Calderwood, Calderwood, Carilli, Carilli, Castellino, Castellino, Davis, Davis, Elguindi, Elguindi, Farr, Farr, Fernández, Fernández, Flechtner, Flechtner, Flynn, Flynn, Fourie, Fourie, Germeroth, Germeroth, Gragerov, Gragerov, Hartl, Hartl, Ishii, Ishii, Kawakami, Kawakami, Kelley, Kelley, Knarr, Knarr, Laemmli, Laemmli, Landry, Landry, Mayer, Mayer, Mayer, Mayer, Mayer, Mayer, McCarty, McCarty, Milani, Milani, Moroi, Moroi, Multhoff, Multhoff, Noessner, Noessner, Norby, Norby, Stevens, Stevens, Suto, Suto, Takeda, Takeda, Udono, Udono, Udono, Udono, Ueda, Ueda, Visseren, Visseren, Wegele, Wegele, Wölfel, Wölfel, Zheng, Zheng, Zhu, Zhu   +81 more
core   +1 more source

Antigen Presentation in the Gut [PDF]

Canadian Journal of Gastroenterology, 1990
The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells. Candidate antigen-presenting cells in the gut include dendritic cells, macrophages, B lymphocytes, mucosal epithelial cells and endothelial cells.
P Pavli, W Doe
openaire   +2 more sources

Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.

, 2002
Malaria sporozoites induce swift activation of antigen-specific CD8(+) T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of ...
A. Morrot, Ahmed, Altman, Bruno, Bru  a-Romero, Busch, Carvalho, Carvalho, Clyde, F. Zavala, G.-i. Sano, Gilbert, Goossens, Gray, Herrington, Hou, J. C. R. Hafalla, Kaech, Kundig, L. H. Carvalho, Lalvani, Lau, Li, Mercado, Mullbacher, Murali-Krishna, Oehen, Oliveira-Ferreira, Plebanski, Plebanski, Renggli, Rodrigues, Rodrigues, Rodrigues, Rodrigues, Romero, Scheller, Schneider, Sedegah, Shinkai, Tanchot, van Stipdonk, Vanderberg, Veiga-Fernandes, Weiss   +44 more
core   +2 more sources

Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]

, 2016
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC, Chen, Xiangjun, Liu, Wanli, Robinson, Marcus J, Smith, Geoffrey A, Taunton, Jack, Yang, Zhiyong   +6 more
core   +1 more source

Autophagy and antigen presentation [PDF]

Cellular Microbiology, 2006
CD4(+) T cells co-ordinate adaptive immunity and are required for immunological memory establishment and maintenance. They are thought to primarily recognize extracellular antigens, which are endocytosed, processed by lysosomal proteases and then presented on major histocompatibility complex (MHC) class II.
openaire   +2 more sources

A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo [PDF]

, 2018
Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity.
Baz Morelli, Adriana, Benson, Robert A., Brewer, James M., Garside, Paul, Hayes, Alan J., Maraskovsky, Eugene, Meehan, Gavin R., Scales, Hannah E., Tomura, Michio, Walters, Anne, Watson, Emma   +10 more
core   +3 more sources