Results 31 to 40 of about 3,313,044 (282)

A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation

Science Advances, 2020
A micropeptide encoded by MIR155HG modulates antigen presentation and suppresses autoinflammation through binding to HSC70. Many annotated long noncoding RNAs (lncRNAs) harbor predicted short open reading frames (sORFs), but the coding capacities of ...
Liman Niu, F. Lou, Yang Sun, Libo Sun, Xiaojie Cai, Zhaoyuan Liu, Hong Zhou, Hong Wang, Zhikai Wang, Jing Bai, Q. Yin, Junxun Zhang, Linjiao Chen, Danhong Peng, Zhenyao Xu, Yuanyuan Gao, Sibei Tang, Li Fan, Honglin Wang   +18 more
semanticscholar   +1 more source

Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF. [PDF]

PLoS ONE, 2012
Dynamic changes in the actin cytoskeleton are essential for immune cell function and a number of immune deficiencies have been linked to mutations, which disturb the actin cytoskeleton.
Friederike Jönsson, Christine B Gurniak, Bernhard Fleischer, Gregor Kirfel, Walter Witke   +4 more
doaj   +1 more source

The role of insulin-regulated aminopeptidase in MHC class I antigen presentation

Frontiers in Immunology, 2012
Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
doaj   +1 more source

Improved prediction of MHC II antigen presentation through integration and motif deconvolution of mass spectrometry MHC eluted ligand data

bioRxiv, 2019
Major Histocompatibility Complex II (MHC II) molecules play a key role in the onset and control of cellular immunity. In a highly selective process, MHC II presents peptides derived from exogenous antigens on the surface of antigen presenting cells for T
Birkir Reynisson, C. Barra, S. Kaabinejadian, W. Hildebrand, Bjoern Peters, M. Nielsen   +5 more
semanticscholar   +1 more source

MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation.

Journal of Clinical Investigation, 2020
Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells, current immune checkpoint therapy is set to boost the CD8+ T cell-mediated cytotoxicity. However, this action is eventually dependent on the efficient recognition of
Yuanzhang Fang, Lifei Wang, Changlin Wan, Yifan Sun, Kevin Van der Jeught, Zhuolong Zhou, Tianhan Dong, K. So, Tao Yu, Yujing Li, Haniyeh Eyvani, Austyn B Colter, E. Dong, Sha Cao, Jin Wang, B. Schneider, G. Sandusky, Yunlong Liu, Chi Zhang, Xiongbin Lu, Xinna Zhang   +20 more
semanticscholar   +1 more source

Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes

Frontiers in Immunology, 2017
About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to ...
Frans Bianchi, Johannes Textor, Geert van den Bogaart   +2 more
doaj   +1 more source

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Frontiers in Immunology, 2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek, Esam T. Abualrous, J. Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, F. Noé, C. Freund   +6 more
semanticscholar   +1 more source

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Frontiers in Immunology, 2018
Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In
Xiaolei Pei, Xiaolei Pei, Lauriel Freya Earley, Yi He, Yi He, Xiaojing Chen, Nikita Elexa Hall, Richard Jude Samulski, Richard Jude Samulski, Chengwen Li, Chengwen Li   +10 more
doaj   +1 more source

Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes

eLife, 2023
The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson, Theadora Ceccarelli, Malini Raghavan   +2 more
doaj   +1 more source

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Nature Communications, 2017
Treatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance to these agents remain incompletely characterized and have yet
Moshe Sade-Feldman, Yunxin J. Jiao, Jonathan H. Chen, Michael S. Rooney, Michal Barzily-Rokni, J. Eliane, Stacey L. Bjorgaard, Marc R. Hammond, Hans Vitzthum, S. Blackmon, Dennie T. Frederick, M. Hazar-Rethinam, Brandon Nadres, Emily E. Van Seventer, S. Shukla, K. Yizhak, John P. Ray, D. Rosebrock, D. Livitz, V. Adalsteinsson, G. Getz, L. Duncan, Bo Li, R. Corcoran, D. Lawrence, A. Stemmer-Rachamimov, G. Boland, D. Landau, K. Flaherty, R. Sullivan, N. Hacohen   +30 more
semanticscholar   +1 more source