HLA-E Peptide Repertoire and Dimorphism—Centerpieces in the Adaptive NK Cell Puzzle?
Frontiers in Immunology, 2018 Adaptive Natural Killer (NK) cells, a heterogenous subpopulation of human NK cells with a unique phenotypic and functional signature, became arguably one of the central areas of interest in the field.
Alexander Rölle +4 more
doaj +1 more source
Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]
, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC +6 more
core +1 more source
The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells [PDF]
International Journal of Molecular Sciences, 2021 Professional antigen-presenting cells (APCs), such as dendritic cells and macrophages, are known for their ability to present exogenous antigens to T cells. However, many other cell types, including endothelial cells, fibroblasts, and lymph node stromal cells, are also capable of presenting exogenous antigens to either CD8+ or CD4+ T cells via cross ...
Tom J. Harryvan +3 more
openaire +3 more sources
Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF. [PDF]
PLoS ONE, 2012 Dynamic changes in the actin cytoskeleton are essential for immune cell function and a number of immune deficiencies have been linked to mutations, which disturb the actin cytoskeleton.
Friederike Jönsson +4 more
doaj +1 more source
NLRC5, at the Heart of Antigen Presentation [PDF]
Frontiers in Immunology, 2013 Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate.
Neerincx Andreas +3 more
openaire +5 more sources
The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
doaj +1 more source
Antigen Stability Controls Antigen Presentation [PDF]
Journal of Biological Chemistry, 2004 We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Jean-Luc Tarride +6 more
openaire +3 more sources
Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes
Frontiers in Immunology, 2017 About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to ...
Frans Bianchi +2 more
doaj +1 more source
Antigen processing and presentation an overview [PDF]
Memorias do Instituto Oswaldo Cruz, 1992 Udgivelsesdato: 1992 ...
Soren Buus
doaj +4 more sources
Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes
eLife, 2023 The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson +2 more
doaj +1 more source