Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes +5 more
doaj +6 more sources
Reprogramming Cancer Cells to Antigen-presenting Cells [PDF]
Bio-Protocol, 2023 Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells ...
Alexandra Ferreira +5 more
doaj +2 more sources
Antigen-Presenting Cells in Psoriasis [PDF]
Life, 2022 Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease.
Dóra Antal +4 more
doaj +3 more sources
Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform [PDF]
Drug DeliveryDelivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy.
Barnabas Nyesiga +6 more
doaj +2 more sources
Stratification of Antigen-presenting Cells within the Normal Cornea
Ophthalmology and Eye Diseases, 2009 The composition and location of professional antigen presenting cells (APC) varies in different mucosal surfaces. The cornea, long considered an immune-privileged tissue devoid of APCs, is now known to host a heterogeneous network of bone marrow-derived ...
Jared E. Knickelbein +3 more
doaj +2 more sources
Dendritic cells and HIV transmission: roles and subsets of antigen-presenting cells in the human anogenital tract. [PDF]
PLoS PathogBuffa DJ +9 more
europepmc +2 more sources
Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells [PDF]
Cell Journal, 2023 Objective: Chimeric antigen receptor (CAR) T cell therapy has recently emerged as a promising approach for thetreatment of different types of cancer.
Ali Sayadmanesh +7 more
doaj +1 more source
CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation
Frontiers in Immunology, 2021 Autoimmune uveitis is a sight-threatening ocular inflammatory condition in which the retina and uveal tissues become a target of autoreactive immune cells.
Yoko Okunuki +3 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundSepsis is a life-threatening condition with high mortality. A few studies have emerged utilizing single-cell RNA sequencing (scRNA-seq) to analyze gene expression at the single-cell resolution in sepsis, but a comprehensive high-resolution ...
Tuo Zhang +17 more
doaj +1 more source
Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer
Cells, 2022 Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches.
Enrica Marmonti +2 more
doaj +1 more source