Results 21 to 30 of about 342,290 (286)

The production of IL-12β by mononuclear leucocytes of peripheral blood depending on clinical forms of pulmonary tuberculosis

Бюллетень сибирской медицины, 2012
The aim of this study was to evaluate the level of secretion of IL-12β by mononuclear leukocytes of peripheral blood under infiltrative and disseminated pulmonary tuberculosis.
R. R. Khasanova, O. I. Urazova, Z. K. Khaitova, O. V. Voronkova, V. V. Novitsky   +4 more
doaj   +1 more source

Two Distinct Myeloid Subsets at the Term Human Fetal–Maternal Interface

Frontiers in Immunology, 2017
During pregnancy, immune cells infiltrate the placenta at different stages of fetal development. NK cells and macrophages are the most predominant cell types.
Maria Laura Costa, Maria Laura Costa, Michelle L. Robinette, Mattia Bugatti, Mark S. Longtine, Bryanne N. Colvin, Bryanne N. Colvin, Erica Lantelme, William Vermi, William Vermi, Marco Colonna, D. Michael Nelson, Marina Cella   +12 more
doaj   +1 more source

Human dendritic cell functional specialization in steady state and inflammation

Frontiers in Immunology, 2014
Dendritic cells (DC) represent a heterogeneous population of antigen-presenting cells that are crucial in initiating and shaping immune responses. Although all DC are capable of antigen uptake, processing and presentation to T cells, DC subtypes differ ...
Arjan eBoltjes, Femke eVan Wijk
doaj   +1 more source

Characterization of respiratory dendritic cells from equine lung tissues

BMC Veterinary Research, 2017
Background Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. Previous research demonstrated that DCs have strong potential for anti-viral defense in the host.
Yao Lee, Matti Kiupel, Gisela Soboll Hussey   +2 more
doaj   +1 more source

Liver antigen-presenting cells

Journal of Hepatology, 2011
The liver is an organ in which several major pathogens evade immune clearance and achieve chronicity. How do they do it? Recent research has documented multiple mechanisms by which immune responses in the liver are biased towards tolerance. In this review, the induction of local, intrahepatic tolerance is explored from the perspective of antigen ...
openaire   +2 more sources

Potential use of [gammadelta] T cell-based vaccines in cancer immunotherapy

Frontiers in Immunology, 2014
Immunotherapy is a fast advancing methodology involving one of two approaches: 1) compounds targeting immune checkpoints, and 2) cellular immunomodulators.
Mohd Wajid A. Khan, Matthias eEberl, Bernhard eMoser   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens

Vaccines, 2019
The preferred product characteristics (for chemistry, control, and manufacture), in addition to safety and efficacy, are quintessential requirements for any successful therapeutic.
Cristina Poveda, Amadeo B. Biter, Maria Elena Bottazzi, Ulrich Strych   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells

Haematologica, 2008
Background Adoptive cell therapy with ex vivo expanded autologous antitumor cytotoxic T lymphocytes represents an important therapeutic option as an anticancer strategy.
Roberta Zappasodi, Massimo Di Nicola, Carmelo Carlo-Stella, Roberta Mortarini, Alessandra Molla, Claudia Vegetti, Salvatore Albani, Andrea Anichini, Alessandro M. Gianni   +8 more
doaj   +1 more source