Results 161 to 170 of about 11,539 (211)

Clinicopathological features of gastric Langerhans cell histiocytosis and a literature review. [PDF]

J Clin Exp Hematop
Chen X, Wu Y, Wang X, Yang M, Gao X, Zhang S, Sun H, Zhang Y, Yi H, Zeng Y.   +9 more
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CD1 assembly and the formation of CD1–antigen complexes

Current Opinion in Immunology, 2005
The CD1 antigen presentation system presents lipid antigens to effector T cells, which have diverse roles in antimicrobial responses, antitumor immunity and in regulating the balance between tolerance and autoimmunity. The trafficking of CD1 molecules and lipid antigens facilitates their intersection and binding in specific intracellular compartments ...
David L, Hava, Manfred, Brigl, Peter, van den Elzen, Dirk M, Zajonc, Ian A, Wilson, Michael B, Brenner   +5 more
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Intracellular pathways of CD1 antigen presentation

Nature Reviews Immunology, 2003
Each of the human CD1 proteins takes a different route through secretory and endocytic compartments before finally arriving at the cell surface, where these proteins present glycolipid antigens to T cells. Recent studies have shown that adaptor-protein complexes and CD1-associated chaperones control not only CD1 trafficking, but also the development ...
D Branch, Moody, Steven A, Porcelli
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CD1-mediated antigen presentation of glycosphingolipids

Microbes and Infection, 2000
CD1 proteins are distinguished by their ability to present lipid antigens to T cells. Group II CD1 or CD1d molecules are recognized by the specialized NK T-cell subset, and this reactivity can be greatly augmented by alpha-galactosylceramide, a glycosphingolipid derived from a marine sponge.
O V, Naidenko, Y, Koezuka, M, Kronenberg
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CD1 antigen presentation: how it works

Nature Reviews Immunology, 2007
The classic concept of self-non-self discrimination by the immune system focused on the recognition of fragments from proteins presented by classical MHC molecules. However, the discovery of MHC-class-I-like CD1 antigen-presentation molecules now explains how the immune system also recognizes the abundant and diverse universe of lipid-containing ...
Duarte C, Barral, Michael B, Brenner
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Anatomy of CD1–lipid antigen complexes

Nature Reviews Immunology, 2005
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A', C', F' and T') and two antigen portals (C' and F').
D Branch, Moody, Dirk M, Zajonc, Ian A, Wilson   +2 more
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CD1 Antigen Presentation and Infectious Disease

2002
Taken together, the data generated thus far strongly suggest that CD1 plays a role in the immune response against various infections (table 1). For obvious reasons, the data gathered thus far using model infection systems have focused primarily on the mouse and therefore only examine the role of CD1d.
Christopher C, Dascher, Michael B, Brenner   +1 more
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CD1 and lipid antigens: intracellular pathways for antigen presentation

Current Opinion in Immunology, 2001
Recently, different members of the CD1 family of MHC-like molecules have been shown to sample different intracellular compartments to present lipid and glycolipid antigens to T cells. Emerging models suggest that CD1 may have evolved to monitor the integrity of membrane lipids and/or to present microbial lipid antigens to both alpha beta and gamma ...
J, Jayawardena-Wolf, A, Bendelac
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Antigen‐presenting Function of the TL Antigen and Mouse CD1 Molecules

Immunological Reviews, 1995
The hallmark of all the nonclassical antigen-presenting molecules, including nonclassical class I and nonclassical class II (Karlsson et al. 1992) molecules, is their lack of polymorphism. It is presumed, therefore, that these nonclassical molecules must have a distinct antigen-presenting function in which polymorphism is not advantageous.
HILDE CHEROUTRE, HILDA R. HOLCOMBE, SHABNAM TANGRI, A. RALIL CASTANO, B. MICHALL TEITELL, JEFFREY E. W. MILLER, SUSANNA CARDELL, CHRISTOPHE BENOIST, DIANE MATHIS, WILLIAM D. HUSE, PER A. PETERSON, MITCHELL KRONENBERG   +11 more
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CD1-restricted antigen presentation: an oily matter

Current Opinion in Immunology, 2003
Abstract CD1 molecules control diverse immune functions by presenting self and non-self lipid antigens to T lymphocytes. The recent solution of the human CD1b structure has revealed the first principles for the structural basis of the presentation of unique and overlapping sets of lipids.
Sebastian, Joyce, Luc, Van Kaer
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