Results 171 to 180 of about 18,685 (221)

Effects of oncolytic immunotherapy with RP1 (vusolimogene oderparepvec) on immune cells mediate responsiveness to anti-PD-1 via STING-mediated interferon signaling. [PDF]

J Immunother Cancer
Roulstone V, Kyula J, Appleton E, Bommareddy PK, Patrikeev A, Jones S, Kuncheria L, Chan Wah Hak CM, Foo S, Baldock H, Wongariyapak A, Leslie I, Pickering R, Zierhut C, Smith HG, Mohan N, Murano C, Hubbard LC, Dean I, Patin EC, Gkantalis J, Mansfield D, Pedersen M, McLaughlin M, Goicoechea M, Layzell S, Mannion J, Fernando W, Meier P, Vile R, Melcher A, Coffin RS, Harrington KJ.   +32 more
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γδ T cell receptor recognition of CD1d in a lipid-independent manner. [PDF]

Nat Commun
Rice MT, Gunasinghe SD, Sok CL, Pan M, Lay CS, Gully BS, Rossjohn J.   +6 more
europepmc   +1 more source

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Anatomy of CD1–lipid antigen complexes

Nature Reviews Immunology, 2005
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A', C', F' and T') and two antigen portals (C' and F').
D Branch, Moody, Dirk M, Zajonc, Ian A, Wilson   +2 more
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CD1 antigen presentation: how it works

Nature Reviews Immunology, 2007
The classic concept of self-non-self discrimination by the immune system focused on the recognition of fragments from proteins presented by classical MHC molecules. However, the discovery of MHC-class-I-like CD1 antigen-presentation molecules now explains how the immune system also recognizes the abundant and diverse universe of lipid-containing ...
Duarte C, Barral, Michael B, Brenner
openaire   +4 more sources

Intracellular pathways of CD1 antigen presentation

Nature Reviews Immunology, 2003
Each of the human CD1 proteins takes a different route through secretory and endocytic compartments before finally arriving at the cell surface, where these proteins present glycolipid antigens to T cells. Recent studies have shown that adaptor-protein complexes and CD1-associated chaperones control not only CD1 trafficking, but also the development ...
D Branch, Moody, Steven A, Porcelli
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CD1: Antigen Presentation and T Cell Function

Annual Review of Immunology, 2004
▪ Abstract  This review summarizes the major features of CD1 genes and proteins, the patterns of intracellular trafficking of CD1 molecules, and how they sample different intracellular compartments for self- and foreign lipids. We describe how lipid antigens bind to CD1 molecules with their alkyl chains buried in hydrophobic pockets and expose their ...
Manfred, Brigl, Michael B, Brenner
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CD1 assembly and the formation of CD1–antigen complexes

Current Opinion in Immunology, 2005
The CD1 antigen presentation system presents lipid antigens to effector T cells, which have diverse roles in antimicrobial responses, antitumor immunity and in regulating the balance between tolerance and autoimmunity. The trafficking of CD1 molecules and lipid antigens facilitates their intersection and binding in specific intracellular compartments ...
David L, Hava, Manfred, Brigl, Peter, van den Elzen, Dirk M, Zajonc, Ian A, Wilson, Michael B, Brenner   +5 more
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CD1-mediated antigen presentation of glycosphingolipids

Microbes and Infection, 2000
CD1 proteins are distinguished by their ability to present lipid antigens to T cells. Group II CD1 or CD1d molecules are recognized by the specialized NK T-cell subset, and this reactivity can be greatly augmented by alpha-galactosylceramide, a glycosphingolipid derived from a marine sponge.
O V, Naidenko, Y, Koezuka, M, Kronenberg
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CD1 and lipid antigens: intracellular pathways for antigen presentation

Current Opinion in Immunology, 2001
Recently, different members of the CD1 family of MHC-like molecules have been shown to sample different intracellular compartments to present lipid and glycolipid antigens to T cells. Emerging models suggest that CD1 may have evolved to monitor the integrity of membrane lipids and/or to present microbial lipid antigens to both alpha beta and gamma ...
J, Jayawardena-Wolf, A, Bendelac
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Rat CD1 antigen: Structure, expression and function

Transplantation Proceedings, 1997
Abstract Functional significance of CD1 has long been enigmatic since it was defined as human thymus differentiation antigens first by polyclonal rabbit antibodies and then by clusters of monoclonal bodies.1 Recently, several reports showed that CD1 worked as antigen presenting molecules for lipid antigens and as a target ligand for unusual T cells ...
A, Matsuura, Y, Hashimoto, M, Kinebuchi, K, Kasai, S, Ichimiya, S, Katabami, H, Chen, T, Shimizu, K, Kikuchi   +8 more
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