Results 171 to 180 of about 11,539 (211)

Antigen‐presenting Function of the Mouse CD1 Moleculea

Annals of the New York Academy of Sciences, 1996
CD1 molecules are distantly related to major histocompatibility complex (MHC)-encoded class I molecules, and they are coexpressed with beta2 microglobulin (beta2m). In the mouse, CD1 is expressed by intestinal epithelial cells and also by some cells in spleen and lymph node.
S, Tangri, H R, Holcombe, A R, Castaño, J E, Miller, M, Teitell, W E, Huse, P A, Peterson, M, Kronenberg   +7 more
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CD1 Expression on Antigen-Presenting Cells

2007
CD1 proteins present self and microbial glycolipids to CD 1-restricted T cells, or in the case of CD1d, to NKT cells. The CD1 family in humans consists of group I proteins CDla, CDlb, CDlc, and CDle and the group II protein CDld. Rodents express only CDld, but as CD1d is broadly expressed and traffics to all endosomal compartments, this single CD1 ...
S K, Dougan, A, Kaser, R S, Blumberg
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Rat CD1 antigen: Structure, expression and function

Transplantation Proceedings, 1997
Abstract Functional significance of CD1 has long been enigmatic since it was defined as human thymus differentiation antigens first by polyclonal rabbit antibodies and then by clusters of monoclonal bodies.1 Recently, several reports showed that CD1 worked as antigen presenting molecules for lipid antigens and as a target ligand for unusual T cells ...
A, Matsuura, Y, Hashimoto, M, Kinebuchi, K, Kasai, S, Ichimiya, S, Katabami, H, Chen, T, Shimizu, K, Kikuchi   +8 more
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CD1: Antigen Presentation and T Cell Function

Annual Review of Immunology, 2004
▪ Abstract  This review summarizes the major features of CD1 genes and proteins, the patterns of intracellular trafficking of CD1 molecules, and how they sample different intracellular compartments for self- and foreign lipids. We describe how lipid antigens bind to CD1 molecules with their alkyl chains buried in hydrophobic pockets and expose their ...
Manfred, Brigl, Michael B, Brenner
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Antigen-Specific Regulation of CD1 Expression in Humans

Journal of Clinical Immunology, 2000
During the last decade the CD1 family of cell surface glycoproteins has been implicated in the presentation of nonpeptide antigens in man. Recent findings by our group indicate that CD1 molecules also can be involved in the presentation of certain bacterial proteins.
M, Ulanova, A, Tarkowski, S A, Porcelli, L A, Hanson   +3 more
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Mechanisms of lipid antigen presentation by CD1.

Critical reviews in immunology, 1999
CD1 is a family of cell surface glycoproteins that are related in structure and evolutionary origin to the major histocompatibility complex (MHC)-encoded antigen-presenting molecules. In contrast to MHC-encoded antigen-presenting molecules, CD1 binds and presents lipid and glycolipid antigens for specific recognition by T cell antigen receptors. Recent
R M, Jackman, D B, Moody, S A, Porcelli
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Presentation of bacterial lipid antigens by CD1 molecules

Trends in Microbiology, 1998
Human CD1 molecules bind and display or present lipid and glycolipid antigens from mycobacteria for recognition by T cells. Presentation requires uptake of antigen into endosomes, where it binds to CD1. T-cell recognition of CD1-presented nonpeptide antigens is a newly defined immune response that could be important for host defense against a variety ...
T I, Prigozy, M, Kronenberg
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The CD1 family of lipid antigen-presenting molecules

Immunology Today, 1998
Abstract The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting
S A, Porcelli, B W, Segelke, M, Sugita, I A, Wilson, M B, Brenner   +4 more
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Sorting out self and microbial lipid antigens for CD1

Microbes and Infection, 2003
CD1 proteins mediate T cell activation in response to self and foreign lipids, including lipid antigens from the intracellular pathogen Mycobacterium tuberculosis. During natural infections, myeloid cells migrate to sites of infection and use microbial pattern recognition receptors to internalize live bacteria and lipid antigens into the endosomal ...
Carme, Roura-Mir, D Branch, Moody
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New insights into pathways for CD1-mediated antigen presentation

Current Opinion in Immunology, 2004
Recent studies of CD1 structure and intracellular trafficking have demonstrated significant differences among the CD1 isoforms (CD1a, CD1b, CD1c and CD1d). The molecular and structural basis for the differential trafficking of CD1 molecules has also been delineated.
Masahiko, Sugita, Manuela, Cernadas, Michael B, Brenner   +2 more
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