Results 191 to 200 of about 18,685 (221)
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New insights into pathways for CD1-mediated antigen presentation
Current Opinion in Immunology, 2004Recent studies of CD1 structure and intracellular trafficking have demonstrated significant differences among the CD1 isoforms (CD1a, CD1b, CD1c and CD1d). The molecular and structural basis for the differential trafficking of CD1 molecules has also been delineated.
Masahiko, Sugita +2 more
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CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens
Science, 1995It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans.
P. A. Sieling +10 more
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Sorting out self and microbial lipid antigens for CD1
Microbes and Infection, 2003CD1 proteins mediate T cell activation in response to self and foreign lipids, including lipid antigens from the intracellular pathogen Mycobacterium tuberculosis. During natural infections, myeloid cells migrate to sites of infection and use microbial pattern recognition receptors to internalize live bacteria and lipid antigens into the endosomal ...
Carme, Roura-Mir, D Branch, Moody
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Capturing the antigen landscape: HLA-E, CD1 and MR1
Current Opinion in Immunology, 2019T cell receptor (TCR) recognition of antigens presented by relatively non-polymorphic MHC-like molecules is emerging as a significant contributor to health and disease. These evolutionarily ancient pathways have been inappropriately labelled 'non-conventional' because their roles were discovered after viral-specific peptide presentation by polymorphic ...
Graham, Ogg +2 more
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Lipid-antigen presentation by CD1 is crystal clear
Trends in Immunology, 2002Molecular recognition of foreign or cancerous antigens by T cells requires antigen presentation by the MHC – dual recognition mode of T-cell receptors (TCRs). Peptide antigens are presented by classical MHC, whereas the non-classical MHC, CD1, presents lipid antigens, for example, mycobacterial phospholipids, glycolipids and self-gangliosides. Although
Zihe Rao, George F. Gao
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Structures and Functions of Microbial Lipid Antigens Presented by CD1
2007The CD1 family of proteins has evolved to bind a range of endogenous and foreign lipids and present these at the cell surface for antigen-specific recognition by T cells. The distinct intracellular trafficking pathways of CD 1 molecules indicate that collectively, they have the potential to survey the endocytic system widely for antigen, consistent ...
B E, Willcox +3 more
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Individual antigens of cattle. Bovine CD1 (BoCD1).
Veterinary immunology and immunopathology, 1991The results support the view that these mAbs can be regarded as equivalent to CD1 mAbs in man, as has been concluded for certain of them previously. Although mAb 20-27 did not cluster with the other mAbs, the finding that it precipitated the same molecule from thymocytes indicates that it should be included in BoCD1.
K R, Parsons, N D, MacHugh
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[Langerhans cell: CD1 antigens and the Birbeck granule].
Pathologie-biologie, 1988Langerhans cells are characterized by two types of markers: an ultrastructural marker, the Birbeck granule and different membrane markers: HLA-D antigens, T4 antigen, and some of the CD1 antigens. These antigens which are specific for the epidermal Langerhans cells, are not expressed by the other epidermal cells.
A, Ray, D, Schmitt
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CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms
Cell, 2023Shouxiong Huang +2 more
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T Cell Activation by CD1 and Lipid Antigens
2007Section 1 - Molecular Biology.- Chapter 1 - Evolutionary Biology of the CD1.- Chapter 2 - Architecture of CD1 Proteins.- Chapter 3 - Structures and Biology of Self Lipid Antigens.- Chapter 4 - Structures and Functions of Microbial Lipid Antigens.- Section 2 - Cellular Biology.- Chapter 5 - CD1 Expression on Antigen Presenting Cells.- Chapter 6 ...
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