Results 181 to 190 of about 18,685 (221)

CD1-restricted antigen presentation: an oily matter

Current Opinion in Immunology, 2003
Abstract CD1 molecules control diverse immune functions by presenting self and non-self lipid antigens to T lymphocytes. The recent solution of the human CD1b structure has revealed the first principles for the structural basis of the presentation of unique and overlapping sets of lipids.
Sebastian, Joyce, Luc, Van Kaer
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CD1 Antigen Presentation and Infectious Disease

2002
Taken together, the data generated thus far strongly suggest that CD1 plays a role in the immune response against various infections (table 1). For obvious reasons, the data gathered thus far using model infection systems have focused primarily on the mouse and therefore only examine the role of CD1d.
Christopher C, Dascher, Michael B, Brenner   +1 more
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CD1 Expression on Antigen-Presenting Cells

2007
CD1 proteins present self and microbial glycolipids to CD 1-restricted T cells, or in the case of CD1d, to NKT cells. The CD1 family in humans consists of group I proteins CDla, CDlb, CDlc, and CDle and the group II protein CDld. Rodents express only CDld, but as CD1d is broadly expressed and traffics to all endosomal compartments, this single CD1 ...
S K, Dougan, A, Kaser, R S, Blumberg
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Antigen‐presenting Function of the Mouse CD1 Moleculea

Annals of the New York Academy of Sciences, 1996
CD1 molecules are distantly related to major histocompatibility complex (MHC)-encoded class I molecules, and they are coexpressed with beta2 microglobulin (beta2m). In the mouse, CD1 is expressed by intestinal epithelial cells and also by some cells in spleen and lymph node.
S, Tangri, H R, Holcombe, A R, Castaño, J E, Miller, M, Teitell, W E, Huse, P A, Peterson, M, Kronenberg   +7 more
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Presentation of bacterial lipid antigens by CD1 molecules

Trends in Microbiology, 1998
Human CD1 molecules bind and display or present lipid and glycolipid antigens from mycobacteria for recognition by T cells. Presentation requires uptake of antigen into endosomes, where it binds to CD1. T-cell recognition of CD1-presented nonpeptide antigens is a newly defined immune response that could be important for host defense against a variety ...
T I, Prigozy, M, Kronenberg
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The CD1 family of lipid antigen-presenting molecules

Immunology Today, 1998
Abstract The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting
S A, Porcelli, B W, Segelke, M, Sugita, I A, Wilson, M B, Brenner   +4 more
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Lipid metabolism, atherogenesis and CD1-restricted antigen presentation

Trends in Molecular Medicine, 2006
CD1 molecules are a family of major histocompatibility complex (MHC)-related glycoproteins that present lipid and glycolipid antigens to T cells. Interestingly, it has been demonstrated that CD1d-restricted T cells have a pathogenic role in atherosclerosis.
Amy S, Major, Sebastian, Joyce, Luc, Van Kaer   +2 more
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Mechanisms of lipid antigen presentation by CD1.

Critical reviews in immunology, 1999
CD1 is a family of cell surface glycoproteins that are related in structure and evolutionary origin to the major histocompatibility complex (MHC)-encoded antigen-presenting molecules. In contrast to MHC-encoded antigen-presenting molecules, CD1 binds and presents lipid and glycolipid antigens for specific recognition by T cell antigen receptors. Recent
R M, Jackman, D B, Moody, S A, Porcelli
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Antigen-Specific Regulation of CD1 Expression in Humans

Journal of Clinical Immunology, 2000
During the last decade the CD1 family of cell surface glycoproteins has been implicated in the presentation of nonpeptide antigens in man. Recent findings by our group indicate that CD1 molecules also can be involved in the presentation of certain bacterial proteins.
M, Ulanova, A, Tarkowski, S A, Porcelli, L A, Hanson   +3 more
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Antigen‐presenting Function of the TL Antigen and Mouse CD1 Molecules

Immunological Reviews, 1995
The hallmark of all the nonclassical antigen-presenting molecules, including nonclassical class I and nonclassical class II (Karlsson et al. 1992) molecules, is their lack of polymorphism. It is presumed, therefore, that these nonclassical molecules must have a distinct antigen-presenting function in which polymorphism is not advantageous.
HILDE CHEROUTRE, HILDA R. HOLCOMBE, SHABNAM TANGRI, A. RALIL CASTANO, B. MICHALL TEITELL, JEFFREY E. W. MILLER, SUSANNA CARDELL, CHRISTOPHE BENOIST, DIANE MATHIS, WILLIAM D. HUSE, PER A. PETERSON, MITCHELL KRONENBERG   +11 more
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