Results 181 to 190 of about 11,539 (211)
Some of the next articles are maybe not open access.
Innate and adaptive functions of the CD1 pathway of antigen presentation
Seminars in Immunology, 1998In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to alphabeta T cells.
S H, Park +5 more
openaire +2 more sources
Lipid metabolism, atherogenesis and CD1-restricted antigen presentation
Trends in Molecular Medicine, 2006CD1 molecules are a family of major histocompatibility complex (MHC)-related glycoproteins that present lipid and glycolipid antigens to T cells. Interestingly, it has been demonstrated that CD1d-restricted T cells have a pathogenic role in atherosclerosis.
Amy S, Major +2 more
openaire +2 more sources
Capturing the antigen landscape: HLA-E, CD1 and MR1
Current Opinion in Immunology, 2019T cell receptor (TCR) recognition of antigens presented by relatively non-polymorphic MHC-like molecules is emerging as a significant contributor to health and disease. These evolutionarily ancient pathways have been inappropriately labelled 'non-conventional' because their roles were discovered after viral-specific peptide presentation by polymorphic ...
Graham, Ogg +2 more
openaire +2 more sources
Structures and Functions of Microbial Lipid Antigens Presented by CD1
2007The CD1 family of proteins has evolved to bind a range of endogenous and foreign lipids and present these at the cell surface for antigen-specific recognition by T cells. The distinct intracellular trafficking pathways of CD 1 molecules indicate that collectively, they have the potential to survey the endocytic system widely for antigen, consistent ...
B E, Willcox +3 more
openaire +2 more sources
Lipid-antigen presentation by CD1 is crystal clear
Trends in Immunology, 2002Molecular recognition of foreign or cancerous antigens by T cells requires antigen presentation by the MHC – dual recognition mode of T-cell receptors (TCRs). Peptide antigens are presented by classical MHC, whereas the non-classical MHC, CD1, presents lipid antigens, for example, mycobacterial phospholipids, glycolipids and self-gangliosides. Although
Zihe Rao, George F. Gao
openaire +1 more source
The versatility of the CD1 lipid antigen presentation pathway
Immunology, 2018The family of non-classical MHC class-I like CD1 molecules has an emerging role in human disease. Group 1 CD1 includes CD1a, CD1b, and CD1c which function to display lipids on the cell surface of antigen presenting cells for direct recognition by T cells.
Stephan D Gadola, Salah Mansour
exaly +2 more sources
The CD1 Family: A Third Lineage of Antigen-Presenting Molecules
1995Publisher Summary This chapter discusses the CD1 structure and function in humans and other mammals, and the manner in which the CD1 family may contribute to the overall maintenance of specific immunity. CD1 has been studied at the serologic, protein, and molecular levels in humans and in several other species including rodents, rabbit, and sheep ...
openaire +2 more sources
Individual antigens of cattle. Bovine CD1 (BoCD1).
Veterinary immunology and immunopathology, 1991The results support the view that these mAbs can be regarded as equivalent to CD1 mAbs in man, as has been concluded for certain of them previously. Although mAb 20-27 did not cluster with the other mAbs, the finding that it precipitated the same molecule from thymocytes indicates that it should be included in BoCD1.
K R, Parsons, N D, MacHugh
openaire +1 more source
CD1 and the expanding universe of T cell antigens
The Journal of Immunology, 1995S A, Porcelli, R L, Modlin
openaire +2 more sources
T Cell Activation by CD1 and Lipid Antigens
2007Section 1 - Molecular Biology.- Chapter 1 - Evolutionary Biology of the CD1.- Chapter 2 - Architecture of CD1 Proteins.- Chapter 3 - Structures and Biology of Self Lipid Antigens.- Chapter 4 - Structures and Functions of Microbial Lipid Antigens.- Section 2 - Cellular Biology.- Chapter 5 - CD1 Expression on Antigen Presenting Cells.- Chapter 6 ...
openaire +1 more source