Results 31 to 40 of about 214,371 (284)

Lymphocyte Differentiation and Effector Functions

Clinical and Developmental Immunology, 2012
Lymphocytes are essential in combating infections; they display powerful effector mechanisms and their activity must be regulated at all times to avoid self-tissue or cells destruction.
Niels Olsen Saraiva Câmara, A. Lepique, A. Basso   +2 more
semanticscholar   +1 more source

PD-1+CXCR5−CD4+ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma

Journal for ImmunoTherapy of Cancer, 2021
Background A major current challenge is to exploit tertiary lymphoid structures (TLSs) to promote the lymphocyte infiltration, activation and differentiation by tumor antigens to increase antitumor immune responses.
Shu-Mei Yan, Jiang-Ping Li, Chang-You Wu, Ming-Yuan Chen, Shang-Xin Liu, Yin-Feng Kang, Cong Sun, Jennifer R Grandis, Mu-Sheng Zeng, Qian Zhong   +9 more
doaj   +1 more source

Structure and function of T lymphocyte differentiation antigens

Trends in Genetics, 1986
Abstract In addition to the T cell reception for antigen, T lymphocytes express a variety of additional T cell-specific surface molecules which are involved in recognition, activation and function. The structure, evolutionary relationship and functions of four of these T cell differentiation antigens are discussed.
openaire   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Human T lymphocyte differentiation antigens: Effects of blood sample storage on LEU antibody binding [PDF]

Cytometry, 1983
AbstractCurrent studies of human T lymphocytes and their subsets often use quantitative immunofluorescence analysis with monoclonal antibodies against cell surface antigens. With storage of whole blood or separated mononuclear cells for more than a few hours we have found marked changes in lymphocyte analysis using a fluorescence activated cell sorter (
P A, Hensleigh, V B, Waters, L A, Herzenberg   +2 more
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Notch signaling pathway in the development of imbalanced immune responses in patients with disseminated pulmonary tuberculosis

Бюллетень сибирской медицины
Aim. To determine the role of the Notch signaling pathway in the regulation of Th1 / Th2 lymphocyte balance in patients with disseminated drug-sensitive (DS) and drug-resistant (DR) pulmonary tuberculosis (PT).Materials and methods.
A. E. Sanina, V. A. Serebryakova, O. I. Urazova, A. A. Gadzhiev   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Cell-Mediated Immunity in Multiple Sclerosis Patients Who Discontinued Therapy with an Integrin Inhibitor [PDF]

Анналы клинической и экспериментальной неврологии
Introduction. Natalizumab (NTZ) is a humanized monoclonal antibody (mAb) that selectively inhibits α4-integrin adhesion molecule located on the surface of lymphocytes and prevents their trafficking into the central nervous system (CNS).
Yuliana A. Belova, Yulia Yu. Chuksina, Sergey V. Kotov, Irina A. Vasilenko   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source