Results 1 to 10 of about 177,963 (215)

Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/ progenitor cells--implication for the pathogenesis of immune thrombocytopenias. [PDF]

open access: yesFolia Histochemica et Cytobiologica, 2007
The pathogenesis and tissue damage that accompanies destruction of platelets in immune thrombocytopenias (IT) is still not understood very well and in addition to platelets, other cells (e.g.
Mariusz Z Ratajczak   +5 more
doaj   +7 more sources

Allele and haplotype frequencies of human platelet and leukocyte antigens in platelet donors [PDF]

open access: yesEinstein (São Paulo), 2019
Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood.
Valeria de Freitas Dutra   +6 more
doaj   +5 more sources

Platelet antibody detection assays: a single-laboratory comparison of MAIPA, PIFT, and microsphere-based multiplex assays Pak-Lx [PDF]

open access: yesHematology, Transfusion and Cell Therapy
Background and Objectives: The identification of platelet antibodies is essential for diagnosing and managing conditions such as fetal and neonatal alloimmune thrombocytopenic purpura, post-transfusion purpura, and immune platelet refractoriness ...
Thiago Henrique Costa   +2 more
doaj   +2 more sources

Association of the human platelet antigens polymorphisms with platelet count in patients with COVID-19

open access: yesFrontiers in Medicine, 2023
Polymorphism in human platelet antigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa), HPA-5 (GPIa/IIa), & HPA-15 (CD109) was investigated in 86 COVID-19-infected patients with thrombocytopenia (Group A) and 136 COVID-19-infected ...
Kazem Ghaffari   +9 more
doaj   +3 more sources

Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets

open access: yesHaematologica, 2022
Approximately 20% of patients receiving multiple platelet transfusions develop platelet alloantibodies, which can be directed against human leukocyte antigens (HLA) and, to a lesser extent, against human platelet antigens (HPA).
Thijs L.J. van Osch   +16 more
doaj   +1 more source

Human platelet antigens – 2013 [PDF]

open access: yesVox Sanguinis, 2013
To date, 33 human platelet alloantigens (HPAs) have been identified on six functionally important platelet glycoprotein (GP) complexes and have been implicated in alloimmune platelet disorders including foetal and neonatal alloimmune thrombocytopenia (FNAIT), posttransfusion purpura (PTP) and multitransfusion platelet refractoriness (MPR). The greatest
Brian R. Curtis, Janice G. McFarland
openaire   +3 more sources

Genotyping of Human Platelet Antigen-1 to -5 and -15 by Polymerase Chain Reaction with Sequence-specific Primers (PCR-SSP) and Real-time PCR in Azeri Blood Donors

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2021
Human platelet antigens (HPAs) are glycoproteins on the platelet surface that a single nucleotide mutation in the coding region gene could lead to the variation of different HPA polymorphisms. These antigens have shown variation among different races and
Seyed Ghader Azizi   +3 more
doaj   +1 more source

The origin of ABH antigens on human platelets [PDF]

open access: yesBlood, 1985
Abstract ABH antigens are present on platelets from individuals of the corresponding red cell phenotype, but the extent to which these antigens are intrinsic or adsorbed remains undefined. To evaluate platelets for intrinsic H substance, an IgM mouse monoclonal antibody against type 2H chain (the intrinsic H structure found on ...
Wendell F. Rosse   +3 more
openaire   +4 more sources

Simultaneous genotyping for human platelet antigen systems and HLA-A and HLA-B loci by targeted next-generation sequencing

open access: yesFrontiers in Immunology, 2022
In order to treat the alloimmunization platelet transfusion refractoriness (PTR), human leukocyte antigen (HLA)-type and/or human platelet antigen (HPA)-type matched platelets between donors and patients are usually used.
Jielin Wang   +13 more
doaj   +1 more source

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