Results 161 to 170 of about 135,006 (287)

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

Fabrication and Bioactivity of Peptide‐Conjugated Biomaterial Tissue Engineering Constructs

Macromolecular Rapid Communications, Volume 44, Issue 1, January 2023., 2023
Various fabrication techniques can be used to form tissue engineering constructs. These constructs can be conjugated with peptides in a straightforward fashion providing them with bioactivity. Peptides afford distinct advantages over other techniques for imparting bioactivity making peptide‐conjugated constructs excellent candidates to improve healing ...
Nicholas Nun, Abraham Joy
wiley   +1 more source

Development of detection kit for anti-platelet antibodies in patients with thrombocytopenia by modified SPRCA

Journal of Associated Medical Sciences, 2008
Detection of anti-platelet alloantibodies in serum of patients with thrombocytopenia is important for helps in diagnosis and investigation as well as specific treatment. Since, platelets provide both common and platelet specific antigens which can induce
Witoon Sriwichai, Jaturaporn Pornsinlapatip, Preeyanat Vongchan   +2 more
doaj  

Sacrificial strategy towards the formation of vascular‐like networks in volumetric tissue constructs

BMEMat, EarlyView.
This mini‐review highlights the latest progress in the sacrificial template‐enabled creation of patent vascular‐like networks, which can be incorporated into volumetric tissue constructs. Such microchannel networks can provide an immediate supply of nutrition and O2 to those cells residing next to the channels.
Christian Buckley, Rana Ibrahim, Felicia Giordano, Nuo Xu, Brandon Sems, Hongjun Wang   +5 more
wiley   +1 more source

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source

Monocyte-Platelet Aggregates Are Major Source of BDNF after Bacterial Stimulation of Human Peripheral Blood Immune Cells. [PDF]

Eur J Immunol
Sarcletti F, Dijmarescu M, Eigenschink M, Wukowits N, Oehler B, Mayer T, Pell S, Tandecki A, Seki D, Spittler A, Berry D, Berger A, Wisgrill L.   +12 more
europepmc   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Advances in analytical microfluidic workflows for differential cancer diagnosis

Nano Select, Volume 4, Issue 1, Page 1-47, January 2023., 2023
Microfluidics holds a great potential for an analytical examination of liquid biopsy and the development of point‐of‐care testing devices. This review overviews fundamentals and technological breakthroughs of immunolabeled and label‐free analytical microfluidic devices for screening and examining CTCs, describes engineering‐driven workflows for ...
Morteza Hasanzadeh Kafshgari, Oliver Hayden   +1 more
wiley   +1 more source

Management challenge of a rare concomitant platelet glycoprotein IV/CD36 and IIb/IIIa deficiencies: Case illustration. [PDF]

Transfusion
Sekayan T, Allen ES, Kopko P, Stephens LD, Zhao M, Curtis BR, Sullivan MJ, Trapp-Stamborski V, von Drygalski A.   +8 more
europepmc   +1 more source

Human platelet antigen Duv genotyping by PCR-SSP [PDF]

Journal of Thrombosis and Haemostasis, 2003
V. Jallu, C. Kaplan
openaire   +3 more sources