Results 21 to 30 of about 18,221 (161)

Molecular players of homologous recombination in protozoan parasites: implications for generating antigenic variation

Infection, Genetics and Evolution, 2004
A major impediment to vaccine development against infections caused by protozoan parasites such as Plasmodium falciparum and Trypanosoma is the extraordinary ability of these parasites to rapidly change their surface molecules, a phenomenon known as antigenic variation.
Mrinal Kanti, Bhattacharyya, Douglas E, Norris, Nirbhay, Kumar   +2 more
openaire   +3 more sources

VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases

Vaccines, 2021
Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need.
Aline Maria Vasconcelos Queiroz, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, Diego M. A. Guérin, Marcelo Sousa Silva   +4 more
doaj   +1 more source

B-Cell Response during Protozoan Parasite Infections

Journal of Parasitology Research, 2012
In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma ...
María C. Amezcua Vesely, Daniela A. Bermejo, Carolina L. Montes, Eva V. Acosta-Rodríguez, Adriana Gruppi   +4 more
doaj   +1 more source

Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort [version 2; referees: 2 approved]

Wellcome Open Research, 2018
Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the
Ruth E. Mitchell, Hannah J. Jones, Robert H. Yolken, Glen Ford, Lorraine Jones-Brando, Susan M. Ring, Alix Groom, Sophie FitzGibbon, George Davey Smith, Nicholas J. Timpson   +9 more
doaj   +1 more source

Stress-Dependent Expression of a Polymorphic, Charged Antigen in the Protozoan Parasite Entamoeba histolytica [PDF]

Infection and Immunity, 2003
ABSTRACT We have identified a novel stress inducible gene, Ehssp1 in Entamoeba histolytica , the causative agent of amebiasis. Ehssp1 belongs to a polymorphic, multigene family and is present on multiple chromosomes. No homologue of this gene was found in the NCBI database.
S, Satish, Abhijeet A, Bakre, Sudha, Bhattacharya, Alok, Bhattacharya   +3 more
openaire   +2 more sources

Surface antigen cross-linking triggers forced exit of a protozoan parasite from its host. [PDF]

Proceedings of the National Academy of Sciences, 1996
We used the common fish pathogen Ichthyophthirius multifiliis as a model for studying interactions between parasitic ciliates and their vertebrate hosts. Although highly pathogenic, Ichthyophthirius can elicit a strong protective immune response in fish after exposure to controlled infections. To investigate the mechanisms underlying host resistance, a
T G, Clark, T L, Lin, H W, Dickerson
openaire   +2 more sources

Immunogenic Evaluation of Ribosomal P-Protein Antigen P0, P1, and P2 and Pentameric Protein Complex P0-(P1-P2)2 of Plasmodium falciparum in a Mouse Model

Journal of Immunology Research, 2019
Malaria remains one the most infectious and destructive protozoan diseases worldwide. Plasmodium falciparum, a protozoan parasite with a complex life cycle and high genetic variability responsible for the difficulties in vaccine development, is ...
Agnieszka Szuster-Ciesielska, Leszek Wawiórka, Dawid Krokowski, Nikodem Grankowski, Łukasz Jarosz, Urszula Lisiecka, Marek Tchórzewski   +6 more
doaj   +1 more source

Identification and Analysis of Immunodominant Antigens for ELISA-Based Detection of Theileria annulata. [PDF]

PLoS ONE, 2016
Tropical or Mediterranean theileriosis, caused by the protozoan parasite Theileria annulata, remains an economically important bovine disease in North Africa, Southern Europe, India, the Middle East and Asia.
Huseyin Bilgin Bilgic, Tulin Karagenc, Serkan Bakırcı, Brian Shiels, Andrew Tait, Jane Kinnaird, Hasan Eren, William Weir   +7 more
doaj   +1 more source

Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi [PDF]

BMC Genomics, 2016
The protozoan parasite Trypanosoma cruzi, causative agent of Chagas disease, depends upon a cell surface-expressed trans-sialidase (ts) to avoid activation of complement-mediated lysis and to enhance intracellular invasion. However these functions alone fail to account for the size of this gene family in T.
Weatherly, D. Brent, Peng, Duo, Tarleton, Rick L.   +2 more
openaire   +2 more sources

Surface antigenic change during differentiation of a parasitic protozoan, Leishmania mexicana: Identification by monoclonal antibodies. [PDF]

Proceedings of the National Academy of Sciences, 1982
The fusion of SP2/0 myeloma cells with spleen cells from mice immunized with Leishmania mexicana amazonensis promastigotes produced hybridoma clones. Indirect immunofluorescent antibody assay with live leishmanias showed that the monoclonal antibody 6H12 recognized only the antigens bound to the surface of L. mexicana amazonensis promastigotes. It also
Fong, D, Chang, K
openaire   +2 more sources