Results 91 to 100 of about 9,201,478 (158)

Liposome‐Based Potential Vaccines Platforms that Are Noncytotoxic

ChemistryOpen
Synthetic vaccines represent a promising avenue in cancer immunotherapy by promoting targeted immune responses. Liposomal technologies have further advanced synthetic vaccinology by enabling the efficient delivery of tumor‐associated carbohydrate ...
Saida Mebarek, Killian Jacob, Carmela Ilaria Pierro, Davide Romanini, Michele Fiore   +4 more
doaj   +1 more source

The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses

Vaccines
Background/Objectives: The MHCII-dependent, CD4+ T-cell zwitterionic polysaccharide PS A1 has been investigated as a promising carrier for vaccine development because it can induce an MHCII-dependent CD4+ response towards a variety of tumor-associated ...
Sharmeen Nishat, Md Kamal Hossain, Geraud Valentin, Farzana Hossain, Shanika Gamage, Katherine A. Wall, Peter R. Andreana   +6 more
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Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma

Scientific Reports
Alterations in protein glycosylation are observed in many solid tumor types leading to formation of tumor-associated carbohydrate antigens (TACAs). The most common TACA is the Tn antigen (CD175), which is a mucin-type O-GalNAc-Ser/Thr/Tyr glycan in ...
Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings   +7 more
doaj   +1 more source

The characterisation of the peanut agglutinin an evolved plant lectin, with improved specificity to the Thompson Freidenriech antigen [PDF]

, 2013
Includes abstract.Includes bibliographical references.Peanut agglutinin (PNA), a carbohydrate binding protein, is able to recognise and bind a number of distinct carbohydrate structures that have been implicated in a number of disease pathologies in ...
Lagardien, Zaida
core   +1 more source

Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers

EJNMMI Research
Background Near-infrared fluorescence (NIRF) imaging assists surgeons intraoperatively to achieve radical resection of malignant tissue with one centimeter depth and can be supplemented with photoacoustic imaging to increase depth-of-view.
Ruben D. Houvast, Vincent Q. Sier, Maurice van Duijvenvoorde, Victor M. Baart, Timo Schomann, JiaXin Chua, Mireille Vankemmelbeke, Lindy G. Durrant, Daniëlle Krijgsman, Pieter de Heer, Gert-Jan Hassing, J. Sven D. Mieog, A. Stijn L. P. Crobach, Jacobus Burggraaf, Peter J.K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier   +16 more
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Glycomics in Human Diseases and Its Emerging Role in Biomarker Discovery

Biomedicines
Glycosylation, the enzymatic addition of glycans to proteins and lipids, is a critical post-translational modification that influences protein folding, stability, trafficking, immune modulation, and cell signaling.
Sherifdeen Onigbinde, Moyinoluwa Adeniyi, Oluwatosin Daramola, Favour Chukwubueze, Md Mostofa Al Amin Bhuiyan, Judith Nwaiwu, Tuli Bhattacharjee, Yehia Mechref   +7 more
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Unraveling the role of C1GALT1 in abnormal glycosylation and colorectal cancer progression

Frontiers in Oncology
C1GALT1 plays a pivotal role in colorectal cancer (CRC) development and progression through its involvement in various molecular mechanisms. This enzyme is central to the O-glycosylation process, producing tumor-associated carbohydrate antigens (TACA ...
Hong Tian, Jia-Li Yu, Xiaoli Chu, Qi Guan, Juan Liu, Ying Liu   +5 more
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Modulation of the Bovine Delayed-Type Hypersensitivity Responses to Defined Mycobacterial Antigens by a Synthetic Bacterial Lipopeptide [PDF]

, 2003
The use of defined protein and peptide antigens can overcome specificity limitations of purified protein derivatives in the detection of bovine tuberculosis when the antigens are used in blood-based tests. Since the use of these specific antigens as skin
Howard, CJ, Hewinson, R. G., Vordermeier, H.M., Clifford, D., Hope, Jayne; id_orcid, Whelan, A O   +5 more
core  

A correlation study of serum tumor markers with systemic lupus erythematosus-associated interstitial lung disease

Frontiers in Medicine
BackgroundSystemic lupus erythematosus-associated interstitial lung disease (SLE-ILD) is a pulmonary manifestation of SLE. Currently, serum biomarkers for early identification of SLE-ILD are lacking.
Xing He, Xing He, Jiaqi Ji, Ting Zhou, Zeli Luo, Siyu Fang, Xixi Chen, Chi Liu, Haiying Yan, Lu Guo   +9 more
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Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation

Diabetes, Metabolic Syndrome and Obesity, 2020
Yu-Cheng Cheng,1 Yu-Hsuan Li,1,2 Chiann-Yi Hsu,3 I-Te Lee1,4– 6 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 2Graduate Institute of Data Science, Taipei Medical ...
Cheng YC, Li YH, Hsu CY, Lee IT
doaj