Results 101 to 110 of about 1,162 (187)

Liposome‐Based Potential Vaccines Platforms that Are Noncytotoxic

ChemistryOpen
Synthetic vaccines represent a promising avenue in cancer immunotherapy by promoting targeted immune responses. Liposomal technologies have further advanced synthetic vaccinology by enabling the efficient delivery of tumor‐associated carbohydrate ...
Saida Mebarek, Killian Jacob, Carmela Ilaria Pierro, Davide Romanini, Michele Fiore   +4 more
doaj   +1 more source

The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses

Vaccines
Background/Objectives: The MHCII-dependent, CD4+ T-cell zwitterionic polysaccharide PS A1 has been investigated as a promising carrier for vaccine development because it can induce an MHCII-dependent CD4+ response towards a variety of tumor-associated ...
Sharmeen Nishat, Md Kamal Hossain, Geraud Valentin, Farzana Hossain, Shanika Gamage, Katherine A. Wall, Peter R. Andreana   +6 more
doaj   +1 more source

Automated Synthesis of the Tumor-Associated Carbohydrate Antigens Gb-3 and Globo-H:  Incorporation of α-Galactosidic Linkages

, 2016
The Globo series of tumor-associated antigens are glycosphingolipids implicated in several cancer types. These oligosaccharides contain an α-linked galactose.
Bastien Castagner (1749490), Daniel B. Werz (1393828), Peter H. Seeberger (255011)   +2 more
core   +1 more source

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma

Scientific Reports
Alterations in protein glycosylation are observed in many solid tumor types leading to formation of tumor-associated carbohydrate antigens (TACAs). The most common TACA is the Tn antigen (CD175), which is a mucin-type O-GalNAc-Ser/Thr/Tyr glycan in ...
Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings   +7 more
doaj   +1 more source

The isolation, purification, tissue localization and identification of a glycoprotein found in the crude mucus gel of patients with carcinoma of the stomach

, 2008
Includes bibliographical references (leaves 101-138).The thin layer of crude mucus lining the human gastric mucosa protects the delicate gastric epithelium from the high shear forces associated with digestion. Gastric mucus is composed largely of water (>
Nthato, Chirwa
core  

Pancreatic Cancer Early Detection Biomarkers for High‐Risk Individuals: Insights From the PRECEDE Consortium

International Journal of Cancer, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington, Maria Raitses‐Gurevich, Giulio Innamorati, Phil A. Hart, Thomas M. Wilkie, Noam Tau, Dana Brin, Doron Yablecovitch, Ido Laish, Dove Keith, Kurt Giles, Jennifer B. Permuth, Diane M. Simeone, George Zogopoulos, Randall E. Brand, John J. Graff, Julie Earl, On behalf of the PRECEDE Consortium, Nikhil Agarwal, Laufey Amundadottir, Michelle Anderson, Ajay Bansal, Todd Bauer, Georg Beyer, Yan Bi, Erkut Borazanci, Randy Brand, Teri Brentnall, Carol Burke, Darren Carpizo, Saurabh Chawla, Daniel Chung, Sourat Darabi, Michael Demeure, Timothy Donahue, Julie Earl, Whitney Espinel, James Farrell, Vigdís Fjóla Stefánsdóttir, Jared Forrester, Eitan Friedman, Paul Franklin, Srinivas Gaddam, Ana García García de Paredes, Steven Gallinger, Talia Golan, Ora Gordon, Robert Grant, William Greenhalf, Eli Marie Grindedal, Aaron Grossberg, Brenda Hafers, Heather Hannon, Sigurdís Haraldsdóttir, Stefán Haraldsson, Peter Hegyi, Melissa Hogg, Amy de Haar‐Holleman, Susan Hong, Greg Idos, Edward Kim, Fay Kastrinos, Bryson Katona, Vivek Kaul, Derk Klatte, Kelsey Klute, Kimberly Ku, Sonia Kupfer, Rich Kwon, Rosario Ligresti, James James Lin, Wei‐Chih (David) Liao, Aimee Lucas, Nipun Merchant, Andrew Metz, Whitney Maxwell, James McLoughlin, Sodech Miclette, Xavier Molero, Leticia Moreira, Takuji Okusaka Chigusa Morizane, Joanne Ngeow, Salvatore Paiella, Jennifer Permuth, Maricel Purcell, Joshua Raff, Vineet Rolston, Intan Schrader, Rosie Sears, Yan‐Shen Shan, Diane Simeone, Jens Siveke, Brett Sheppard, Tyler Stevens, Elena Stoffel, Dan Sussman, Margaret Tempero, Jose Trevino, Jennifer Valerin, Eva Vaquero, Ray Wadlow, Garrett Ward, David Weinberg, Ronald Wolf, Dana Zakalik, George Zogopoulos   +105 more
wiley   +1 more source

Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen

, 2016
The abnormal glycans expressed on the surface of tumor cells, known as tumor-associated carbohydrate antigens, increase the chance to develop carbohydrate-based anticancer vaccines.
Yue Wang (65477), Xin-Shan Ye (1393843), Fan Yang (1413), Chang-Xin Huo (2221666), Xiu-Jing Zheng (2221669), Ye Zhang (132223)   +5 more
core   +2 more sources

Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers

EJNMMI Research
Background Near-infrared fluorescence (NIRF) imaging assists surgeons intraoperatively to achieve radical resection of malignant tissue with one centimeter depth and can be supplemented with photoacoustic imaging to increase depth-of-view.
Ruben D. Houvast, Vincent Q. Sier, Maurice van Duijvenvoorde, Victor M. Baart, Timo Schomann, JiaXin Chua, Mireille Vankemmelbeke, Lindy G. Durrant, Daniëlle Krijgsman, Pieter de Heer, Gert-Jan Hassing, J. Sven D. Mieog, A. Stijn L. P. Crobach, Jacobus Burggraaf, Peter J.K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier   +16 more
doaj   +1 more source

Glycomics in Human Diseases and Its Emerging Role in Biomarker Discovery

Biomedicines
Glycosylation, the enzymatic addition of glycans to proteins and lipids, is a critical post-translational modification that influences protein folding, stability, trafficking, immune modulation, and cell signaling.
Sherifdeen Onigbinde, Moyinoluwa Adeniyi, Oluwatosin Daramola, Favour Chukwubueze, Md Mostofa Al Amin Bhuiyan, Judith Nwaiwu, Tuli Bhattacharjee, Yehia Mechref   +7 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source