Results 71 to 80 of about 44,256 (203)

The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn

Oncotarget, 2016
Tn antigen (GalNAc-α-O-Ser/Thr), a mucin-type O-linked glycan, is a well-established cell surface marker for tumors and its elevated levels have been correlated with cancer progression and prognosis. There are also reports that Tn is elevated in inflammatory tissues. However, the molecular mechanism for its elevated levels in cancer and inflammation is
Ho, Chia-Wen, Lin, Chi-Yu, Liaw, Yi-Wei, Chiang, Hsiao-Ling, Chin, Yu-Tang, Huang, Rui-Lan, Lai, Hung-Cheng, Hsu, Yaw-Wen, Kuo, Po-Jan, Chen, Chiao-En, Lin, Hung-Yun, Whang-Peng, Jacqueline, Nieh, Shin, Fu, Earl, Liu, Leroy F., Hwang, Jaulang   +15 more
openaire   +3 more sources

Discovery of Serotransferrin Glycoforms: Novel Markers for Diagnosis of Liver Periductal Fibrosis and Prediction of Cholangiocarcinoma. [PDF]

, 2019
Cholangiocarcinoma (CCA) caused by chronic liver fluke infection is a major public health problem in Northeast Thailand. Identification of CCA risk groups is urgently needed for the control of CCA in this region.
Barboza, Mariana, Chamadol, Nittaya, Jamnongkan, Wassana, Khuntikeo, Narong, Lebrilla, Carlito B, Loilome, Watcharin, Pairojkul, Chawalit, Sithithaworn, Paiboon, Techasen, Anchalee, Thanan, Raynoo, Yongvanit, Puangrat   +10 more
core   +2 more sources

GMMA decorated with mucin 1 Tn/STn mimetics elicit specific antibodies response and inhibit tumor growth

npj Vaccines
Carbohydrate-based therapeutic vaccines are actively pursued as targeted immunotherapy to treat cancer. Aberrant glycosylation is indeed of paramount importance in tumors, leading to the formation of “neo-epitopes”, known as tumor-associated carbohydrate
Elisa Pesce, Andrea Sodini, Elena Palmieri, Silvia Valensin, Cristina Tinti, Marco Rossi, Antonella De Rosa, Marco Fragai, Francesco Papi, Chiara Cordiglieri, Francesco Berti, Renata Grifantini, Francesca Micoli, Cristina Nativi   +13 more
doaj   +1 more source

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico CA72-4 and CEA in serum and peritoneal washing in gastric cancer

Arquivos de Gastroenterologia, 2002
Racional - O tratamento e o prognóstico dos pacientes com câncer gástrico dependem, principalmente, do estádio clínico. Os marcadores tumorais séricos e do lavado peritonial podem auxiliar a avaliar o risco de recurrência da doença. Casuística e Métodos -
Sandra MANDORWSKI, Laércio Gomes LOURENÇO, Nora Manoukian FORONES   +2 more
doaj   +1 more source

Prognostic and therapeutic significance of carbohydrate antigen 19-9 as tumor marker in patients with pancreatic cancer [PDF]

, 2006
In pancreatic cancer ( PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy ...
Anderson JS, Bekaii-Saab TS, Brambs HJ, Burris HA, Ebrahimi B, Glenn J, Gogas H, Goggins M, Heinemann V, Heinemann V, Heinemann V, Ishii H, Jamieson NB, Jiang XT, Katz A, Ko AH, Koprowski H, Louvet C, Lundin J, Maisey NR, Montgomery RC, Moore MJ, Ni XG, Okusaka T, Petra Stieber, Philip PA, Ralf Wilkowski, Saad ED, Safi F, Safi F, Sakar B, Sawaki A, Sperti C, Stathopoulos GP, Stefan Boeck, Stefan Holdenrieder, Steinberg W, Tanaka N, Tempero MA, Tian F, van Custem E, Vimalachandran D, Volker Heinemann, Wilkowski R, Wilkowski R, Wilkowski R, Willet CG, Wolff RA, Ziske C   +48 more
core   +1 more source

Varied presentation of the Thomsen–Friedenreich disaccharide tumor-associated carbohydrate antigen on gold nanoparticles [PDF]

Carbohydrate Research, 2008
Three-dimensional self-assembled monolayers of gold coated with the Thomsen-Friedenreich antigen (TF(ag)) disaccharide (beta-Galp-(1-->3)-GalpNAc) in a variety of presentations have been prepared and characterized. Anomalies in the size distribution of our originally synthesized TF(ag)-bearing nanoparticles as shown in dynamic light scattering ...
Andreas, Sundgren, Joseph J, Barchi
openaire   +2 more sources

Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. [PDF]

, 2016
Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers.
Cho, Huan-Chieh, Ho, Ming-Yi, Hung, Jung-Tung, Tan, Keng-Poo, Yu, Alice Lin-Tsing, Yu, John   +5 more
core  

High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma. [PDF]

, 2017
Cancer may arise from dedifferentiation of mature cells or maturation-arrested stem cells. Previously we reported that definitive endoderm from which liver was derived, expressed Globo H, SSEA-3 and SSEA-4.
Ho, Ming-Yi, Hsieh, Chung-Bao, Huang, Yen-Lin, Hung, Jung-Tung, Hung, Tsai-Hsien, Kuo, Huan-Hsien, Lin, Ruey-Jen, Lo, Fei-Yun, Yeh, Chau-Ting, Yu, Alice L, Yu, John   +10 more
core   +3 more sources

Evaluation of a Novel Anti-Mucin 1 (MUC1) Antibody (PankoMab) as a Potential Diagnostic Tool in Human Ductal Breast Cancer; Comparison with Two Established Antibodies [PDF]

, 2009
Aim: PankoMab is a novel antibody that recognizes a tumor-specific epitope of Mucin 1 (MUC1). The aim of this study was the evaluation of PankoMab as a potential diagnostic tool and its comparison with two established antibodies against MUC1 in human ...
Dian, Darius, Friese, Klaus, Janni, Wolfgang, Jeschke, Udo, Karsten, Uwe, Kuhn, Christina, Mayr, Doris, Mylonas, Ioannis   +7 more
core   +1 more source

SIALYL LEWISx AS A TUMOR-ASSOCIATED CARBOHYDRATE ANTIGEN IN BREAST CANCER

The journal of the Japanese Practical Surgeon Society, 1989
Operative breast cancers were subjected to a serological and immunohistochemical evaluation of sialyl Lewisx antigen as a tumor-associated one, where a new monoclonal antibody CSLEX1 which reacts with sialyl Lewisx antigen was used. Percent positive of sailayl Lewisx in sera of 30 patients with breast cancer was 30%(9/30), which was better than those ...
Tohru NAKAGOE, Hiroyuki KUSANO, Kouji KIMINO, Yasushi TAGAWA, Katsunobu KAWAHARA, Hiroyoshi AYABE, Takatoshi SHIMOYAMA, Toshio MIURA, Masumi IFUKU   +8 more
openaire   +2 more sources