Results 51 to 60 of about 2,349,446 (385)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Fundamental differences between natural antibodies and polyreactive immunoglobulins [PDF]

The Ukrainian Biochemical Journal, 2015
A problem of similarity and differences between so-called polyreactive immunoglobulins (PRIGs) and natural antibodies (NAbs), capable of cross-reacting with some structurally dissimilar antigens, has been considered.
S. A. Bobrovnik, M. A. Demchenko, S. V. Komisarenko   +2 more
doaj   +1 more source

The Excretion of Antigen [PDF]

Biochemical Journal, 1915
n ...
openaire   +3 more sources

Beyond antigens and adjuvants: formulating future vaccines.

Journal of Clinical Investigation, 2016
The need to optimize vaccine potency while minimizing toxicity in healthy recipients has motivated studies of the formulation of vaccines to control how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following ...
Tyson J. Moyer, Andrew C Zmolek, D. Irvine   +2 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Serological and molecular detection of neurocysticercosis among epileptic patients in Nagpur, Maharashtra state (India)

Helminthologia, 2023
Neurocysticercosis (NCC), one of the most important neuroparasitic diseases in humans, is caused by Cysticercus cellulosae, the metacestode stage of digenetic zoonotic cestode Taenia solium.
Satyaprakash K., Khan W. A., Zade N. N., Chaudhari S. P., Shinde S. V., Kurkure N. V., Shembalkar P. K.   +6 more
doaj   +1 more source

Trypanosoma cruzi Antigenic Proteins Shared with Acute Lymphoblastic Leukemia and Neuroblastoma

Pharmaceuticals, 2022
Background. Research studies indicate that immunization with protein extracts of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, prevents the appearance of tumors in 60% of mice injected with the murine lung carcinoma tumor line ...
Leticia Eligio García, María del Pilar Crisóstomo Vázquez, Víctor Alberto Maravelez Acosta, Mariana Soria Guerrero, Adrián Cortés Campos, Enedina Jiménez Cardoso   +5 more
doaj   +1 more source

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

Journal of Experimental Medicine, 1965
Two methods were used to demonstrate the presence of tumor-specific antigens in adenocarcinomata of the human colon: (a) rabbits were immunized with extracts of pooled colonic carcinomata, and the antitumor antisera thus produced were absorbed with a ...
P. Gold, S. Freedman
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Conservation and global distribution of non-canonical antigens in enterotoxigenic Escherichia coli [PDF]

, 2019
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) cause significant diarrheal morbidity and mortality in children of resource-limited regions, warranting development of effective vaccine strategies.
Boxrud, Dave, Cebelinski, Elizabeth, Del Canto, Felipe, Fleckenstein, James M, Gómez-Duarte, Oscar G, Hazen, Tracy H, Kuhlmann, F. Matthew Matthew, Martin, John, Mitreva, Makedonka, Okhuysen, Pablo C, Pashos, Madeline, Qadri, Firdausi, Rasko, David A, Vickers, Tim J, Vidal, Roberto   +14 more
core   +2 more sources