Results 1 to 10 of about 32,450 (215)
Molecules, 2022 Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant ...
Igor S. Kovalev +5 more
doaj +2 more sources
Anti-VEGF agents with or without antimetabolites in trabeculectomy for glaucoma: a meta-analysis. [PDF]
PLoS ONE, 2014 PURPOSE: We aimed to evaluate the intraoperative application of antimetabolites compared with anti-vascular endothelial growth factor (VEGF) agents with or without antimetabolites in trabeculectomy (Trab) for glaucoma.
Qi Xiong +6 more
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Pharmaceutics, 2023 Nucleoside analogues (NAs) are a family of compounds which include a variety of purine and pyrimidine derivatives, widely used as anticancer and antiviral agents.
Federica De Castro +4 more
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Non-coding RNA Research, 2018 Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs.
Bernhard Biersack
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Novel Active Homo-Aza (Lactam) Steroidal Antimetabolites for the Treatment of Human Pancreatic and Colorectal Cancer [PDF]
PharmaceuticalsBackground: Colorectal and pancreatic cancers remain therapeutically challenging, with limitations in efficacy and limitations due to toxicity from conventional antimetabolites such as 5-fluorouracil (5-FU), methotrexate (MTX), and gemcitabine (GEM ...
Konstantinos E. Alifieris +12 more
doaj +2 more sources
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Khalid J.H. Alzahrani +7 more
doaj +4 more sources
Development of a high-throughput label-free method for enrichment of antimetabolite-resistant yeast strains using pico-litre agarose beads [PDF]
Applied Microbiology and BiotechnologyAntimetabolites, which are structural analogues of metabolites or carbon sources that exhibit toxicity by disrupting metabolism, can couple phenotypes of interest to growth and thereby facilitate the selection of relevant strains from large mutant pools ...
Sagarika B. Govindaraju +3 more
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Journal of Virology, 2023 Zika virus (ZIKV) is a major public health concern of international proportions. While the incidence of ZIKV infections has declined substantially in recent years, the potential for the reemergence or reintroduction remains high.
Bikash R. Sahoo +7 more
semanticscholar +1 more source
Frontiers in Plant Science, 2023 Halo blight is a plant disease that leads to a significant decrease in the yield of common bean crops and kiwi fruits. The infection is caused by Pseudomonas syringae pathovars that produce phaseolotoxin, an antimetabolite which targets arginine ...
Maciej Nielipinski +3 more
doaj +1 more source
Oligonucleotides Carrying Nucleoside Antimetabolites as Potential Prodrugs
Current Medicinal Chemistry, 2021 Background Nucleoside and nucleobase antimetabolites are an important class of chemotherapeutic agents for the treatment of cancer as well as other diseases.
C. Fàbrega +3 more
semanticscholar +1 more source