Results 31 to 40 of about 17,759 (207)

Large Scale Screening of Rhizospheric Allelopathic Bacteria and Their Potential for the Biocontrol of Wheat-Associated Weeds

Agronomy, 2020
Conventional weed control practices have generated serious issues related to the environment and human health. Therefore, there is a demand for the development of alternative techniques for sustainable agriculture.
Tasawar Abbas, Zahir Ahmad Zahir, Muhammad Naveed, Sana Abbas, Mona S. Alwahibi, Mohamed Soliman Elshikh, Adnan Mustafa   +6 more
doaj   +1 more source

MODERN METHODS OF CONTROLLING WOUND HEALING AFTER FISTULIZING GLAUCOMA SURGERY. ANTI-INFLAMMATORY DRUGS AND NEW TRENDS

Oftalʹmologiâ, 2017
The  article  describes  modern approaches  for  controlling  wound  healing  after  fistulizing  glaucoma   surgery.  The  review  recounts international experience of steroidal and nonsteroidal anti-inflammatory drug and their efficacy research study ...
S. Yu. Petrov
doaj   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Artificial Intelligence and Predictive Modelling for Precision Dosing of Immunosuppressants in Kidney Transplantation

Pharmaceuticals
Optimizing immunosuppressant dosing presents significant challenges in kidney transplantation due to narrow therapeutic ranges and considerable inter-patient pharmacokinetic differences.
Sholpan Altynova, Timur Saliev, Aruzhan Asanova, Zhanna Kozybayeva, Saltanat Rakhimzhanova, Aidos Bolatov   +5 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

MODERN ONCO DRUG FOR INTERNAL USE

Фармация и фармакология (Пятигорск), 2018
Despite the development of biotherapy, chemotherapy remains one of the main methods of treatment of cancer patients. Currently, there are more than 100 anticancer drug substances, however, every year new drugs enter clinical practice and various ...
O. L. Orlova, L. L. Nikolaeva, L. A. Korol, M. V. Dmitrieva, A. P. Polozkova, A. V. Lantsova, I. D. Gulyakin, N. A. Oborotova   +7 more
doaj   +1 more source

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population‐Based Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit, Daphna Idan, Ariel Avraham Hasidim, Tal Michael, Amalia Levy, Gali Pariente, Eitan Lunenfeld, Sharon Daniel   +7 more
wiley   +1 more source

Syntheses of Antimetabolites [PDF]

, 1970
In these studies several different types of antimetabolites were synthesized, and their biological effects were examined in various assay systems. More extensive investigations were done in microbial systems in which many of the compounds proved to be ...
Clifton, George Gil
core  

Reduced Dose Methotrexate and Mycophenolate Mofetil in Noninfectious Uveitis: A Sub-Analysis from the First-Line Antimetabolites as Steroid Sparing Therapy (FAST) Trial. [PDF]

, 2023
PURPOSE: Some patients taking methotrexate (MTX) or mycophenolate mofetil (MMF) experience intolerable side effects at full doses. We evaluated whether dose reduction affected treatment outcomes in uveitis patients. METHODS: Subanalysis of the First-line
Kanakath, Anuradha, Reddy, Amit, Suhler, Eric, Doan, Thuy, Acharya, Nisha, Vedhanayaki, Rajesh, Murugan, Bala, Thundikandy, Radhika, Al-Dhibi, Hassan, Rathinam, S, Lim, Lyndell, Gonzales, John, Sun, Yuwei, Sura, Amol   +13 more
core   +1 more source

Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

Molecules, 2020
Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU).
Lázaro de Sousa Fideles, João Antônio Leal de Miranda, Conceição da Silva Martins, Maria Lucianny Lima Barbosa, Helder Bindá Pimenta, Paulo Vitor de Souza Pimentel, Claudio Silva Teixeira, Marina Alves Sampaio Scafuri, Samuel de Osterno Façanha, João Erivan Façanha Barreto, Poliana Moreira de Medeiros Carvalho, Ariel Gustavo Scafuri, Joabe Lima Araújo, Jefferson Almeida Rocha, Icaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Matheus da Silva Campelo, Maria Elenir Nobre Pinho Ribeiro, Gerly Anne de Castro Brito, Gilberto Santos Cerqueira   +19 more
doaj   +1 more source