Results 61 to 70 of about 25,615 (222)

Catalytic Strategies For the Synthesis of Dehydrozingerone: Structural Features and Emerging Applications—A Critical Review

ChemCatChem, Volume 18, Issue 1, 15 January 2026.
This review emphasizes the main methods for synthesizing dehydrozingerone (DHZ), highlighting the aldol condensation reaction of vanillin with acetone using homogeneous and heterogeneous catalysts. Furthermore, the main pharmacological properties that characterize DHZ are presented, along with current challenges and perspectives in its production ...
Paula Ramirez, José J. Martinez, Gustavo Romanelli, Maria H. Brijaldo, Fabio B. Passos   +4 more
wiley   +1 more source

UHPLC-HRMS/MS Chemical Fingerprinting of the Bioactive Partition from Cultivated Piper aduncum L.

Molecules
Piper aduncum L. is widely distributed in tropical regions and the ethnobotanical uses of this species encompass medicinal applications for the treatment of respiratory, antimicrobial, and gynecological diseases.
Adélia Viviane de Luna, Thayssa da Silva Ferreira Fagundes, Ygor Jessé Ramos, Marlon Heggdorne de Araújo, Michelle Frazão Muzitano, Sanderson Dias Calixto, Thatiana Lopes Biá Ventura Simão, George Azevedo de Queiroz, Elsie Franklin Guimarães, André Mesquita Marques, Davyson de Lima Moreira   +10 more
doaj   +1 more source

In-vitro evaluation of the antibacterial activity of the essential oils of Micromeria barbata, Eucalyptus globulus and Juniperus excelsa against strains of Mycobacterium tuberculosis (including MDR), Mycobacterium kansasii and Mycobacterium gordonae

Journal of Infection and Public Health, 2019
Background: Mycobacterium spp. are responsible for several diseases, particularly in immunocompromised populations. The spreading of the resistance to antimycobacterial drugs is a significant problem to the public health and requires to find out a new ...
Khaled El Omari, Monzer Hamze, Saer Alwan, Marwan Osman, Charafeddine Jama, Nour-Eddine Chihib   +5 more
doaj   +1 more source

Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy [PDF]

, 2018
Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic.
Colombo, Maria Isabel, Giai, Constanza, Zarelli, Valeria Eugenia Paola   +2 more
core  

Esters of pyrazinoic acid are active against pyrazinamide-resistant strains of Mycobacterium tuberculosis and other naturally resistant mycobacteria in vitro and ex vivo within macrophages. [PDF]

, 2015
Pyrazinamide (PZA) is active against major Mycobacterium tuberculosis species (M. tuberculosis, M. africanum, and M. microti) but not against M. bovis and M. avium. The latter two are mycobacterial species involved in human and cattle tuberculosis and in
Carmo, N, Constantino, L, Elsa, Anes, Pires, D, Simões, Marta Filipa, Testa, B, Valente, E   +6 more
core   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

MEP Pathway: First-Synthesized IspH-Directed Prodrugs with Potent Antimycobacterial Activity

Microorganisms
We report the first synthesis of IspH-directed prodrugs targeting the terminal enzyme of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH or LytB).
Alizée Allamand, Ludovik Noël-Duchesneau, Cédric Ettelbruck, Edgar De Luna, Didier Lièvremont, Catherine Grosdemange-Billiard   +5 more
doaj   +1 more source

Medications Used Among Nonhospitalized Pregnant Women With COVID‐19: A Prospective Individual Patient Data Meta‐Analysis in Europe and North America

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 1, January 2026.
ABSTRACT Aim To estimate the prevalence of medication use in nonhospitalized pregnant women with COVID‐19. Methods A prospective two‐stage individual patient meta‐analysis across 10 data sources in Europe and North America studied medication use among nonhospitalized pregnant women with COVID‐19 between January 2020 and December 2022.
Odette de Bruin, Emeline Maisonneuve, Eimir Hurley, Hedvig M. E. Nordeng, Anick Bérard, Odile Sheehy, Padma Kaul, Mayura U. Shinde, Austin Cosgrove, Jennifer G. Lyons, Elizabeth Messenger‐Jones, Maria E. Kempner, Sengwee Toh, Wei Hua, José J. Hernández‐Muñoz, Leyla Sahin, Carolyn E. Cesta, David Hägg, Rosa Gini, Olga Paoletti, Beatriz Poblador‐Plou, Sue Jordan, Daniel Thayer, Clara L. Rodríguez‐Bernal, Francisco Sánchez‐Sáez, Régis Lassalle, Marie‐Agnès Bernard, Ema Alsina, Fariba Ahmadizar, Guillaume Favre, Alice Panchaud, Kitty W. M. Bloemenkamp, Kelly Plueschke, Corinne de Vries, Satu J. Siiskonen, Miriam C. J. M. Sturkenboom, on behalf of the CONSIGN Collaboration Group, Benjamin P. Geisler, Mark Walker, Steven Hawken, Sasha Bernatsky, Sherif Eltonsy, Emma Hoffman, Andrew B. Petrone, Jolene Mosley, Jenice Ko, Claudia Bartolini, Giuseppe Roberto, Giorgio Limoncella, Anna Girardi, Giulia Hyeraci, Antonio Gimeno‐Miguel, Jonás Carmona‐Pírez, Antonio Poncel‐Falcó, Aida Moreno‐Juste, Alexandra Prados‐Torres, Ian Farr, Saira Ahmed, Ieuan Scanlon, Gabriel Sanfélix‐Gimeno, Isabel Hurtado, Anibal Garcia‐Sempere, Salvador Peiro, Jérémy Jové, Dunia Sakr, Cécile Droz‐Perroteau, David Baum, Hilde M. Engjom, Mònica Sabaté Gallego, Elena Ballarín Alins, Cristina Aguilera Martin, Melissa Kampman, Celline Brasil   +72 more
wiley   +1 more source

Synthesis of novel triazole hybrids with pyrene, fluorene, and biphenyl groups and evaluation of their antimycobacterial activity

Heterocyclic Communications
The synthesis of 1,2,3-triazoles, which are acting as promising pharmacophores with strong biological activity, is the focus of our work. Three obscure streaks of hybrid molecules with a 1,2,3-triazole nucleus have been synthesized by us.
Goyal Akshi, Bhandari Meena
doaj   +1 more source

Antitubercular Activity of 7-Methyljuglone-Loaded Poly-(Lactide Co-Glycolide) Nanoparticles

Pharmaceutics
Background/Objectives: Loading of natural products into poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as drug delivery systems for the treatment of diseases, such as tuberculosis (TB), has been widely explored.
Bianca Diedericks, Anna-Mari Kok, Vusani Mandiwana, Bhavna Gowan Gordhan, Bavesh Davandra Kana, Suprakas Sinha Ray, Namrita Lall   +6 more
doaj   +1 more source