Results 91 to 100 of about 21,202 (267)

Eugenol‐Based Thiazole Derivatives Inhibit the MepA Efflux Pump in Staphylcoccus aureus

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
ABSTRACT Multidrug resistant (MDR) bacteria are considered critical priority pathogens by the World Health Organization (WHO). Considering the relevance of antibacterial drug development in this scenario, the present research study aimed to evaluate the antibacterial activity of eugenol‐based thiazole derivatives and analyze their potential to inhibit ...
Ray Silva de Almeida, Laís Regina dos Santos Folquitto, Priscilla Ramos Freitas, Ana Carolina Justino de Araujo, Saulo Relison Tintino, Jaime Ribeiro‐Filho, Cícera Datiane de Morais Oliveira‐Tintino, Gustavo Marinho Miranda, Ivaldo Francisco da Silva Junior, Diogo Teixeira Carvalho, Thiago Belarmino de Souza, Danielle Ferreira Dias, Carolina Bandeira Domiciano, Henrique Douglas Melo Coutinho   +13 more
wiley   +1 more source

Licochalcone A as Novel Multitarget Inhibitors via AChE, BuChE, and Synapsin III for Therapeutic Intervention Against Alzheimer’s Disease: Computer‐Aided Drug Design

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Alzheimer’s disease (AD) is characterized by key pathological features, including cholinergic dysfunction, amyloid‐beta (Aβ) aggregation, and disrupted synaptic transmission, positioning proteins such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Synapsin III as critical targets for therapeutic strategies.
Ali Alimari, Bagher Seyedalipour, Payam Baziyar, Ehsan Joz Jalalian, Sohini Basu Roy   +4 more
wiley   +1 more source

Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy [PDF]

, 2018
Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic.
Colombo, Maria Isabel, Giai, Constanza, Zarelli, Valeria Eugenia Paola   +2 more
core  

Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates [PDF]

, 2020
Here we sought to evaluate the contribution of the PBD unit to the biological activity of PBD-conjugates and, to this end, an adenosine nucleoside was attached to the PBD A-ring C8 position.
Bhakta, Sanjib, Brucoli, Federico, Ferguson, Lindsay, Fox, Keith, Wells, Geoff   +4 more
core   +4 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Immunological and microbiological activity of Davilla elliptica St. Hill. (Dilleniaceae) against Mycobacterium tuberculosis

Memorias do Instituto Oswaldo Cruz, 2007
Mycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The immunological activity of Davilla elliptica chloroform extract (DECE) was evaluated
Flávia Cristine Mascia Lopes, Marisa Campos Polesi Placeres, Cleso Mendonça Jordão Junior, Célio Takashi Higuchi, Daniel Rinaldo, Wagner Vilegas, Clarice Queico Fujimura Leite, Iracilda Zeppone Carlos   +7 more
doaj   +1 more source

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents [PDF]

, 2022
Pooja Hegde, Wassihun Wedajo Aragaw, Malcolm S. Cole, Gorakhnath R. Jachak, Priya Ragunathan, Sachin Sharma, Amaravadhi Harikishore, Gerhard Grüber, Thomas Dick, Courtney C. Aldrich   +9 more
openalex   +1 more source

Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay [PDF]

, 2013
Objectives: Lead antituberculosis (anti-TB) molecules with novel mechanisms of action are urgently required to fuel the anti-TB drug discovery pipeline.
Bhakta, Sanjib, Birchall, K., Evangelopoulos, Dimitrios, Gibbons, S., Gupta, Antima, Guzman, Juan D., Malkinson, J., McHugh, T.D., Mwaigwisya, S., Saxty, B.   +9 more
core   +1 more source

Toxic Evaluations of Calea phyllolepis Extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate and Its In Silico Prediction of the Toxicity

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
In vivo and in silico toxicological effects of Calea phyllolepis extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate. ABSTRACT Medicinal plants are traditionally used in folk medicine. Still, there is a misconception about the safety/efficacy of natural treatments, which results in few studies on the toxic, genotoxic, and mutagenic potential of ...
Suele Bierhals Vencato, Guilherme Borsoi, Cleverson Feistel, Mariele Feiffer Charão, Angélica Rocha Joaquim, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz   +6 more
wiley   +1 more source