Results 51 to 60 of about 414,015 (313)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Growth performance and antioxidant status of growing rabbits fed on diets supplemented with Eucommia ulmoides leaves

World Rabbit Science, 2018
The present study evaluated the effect of dietary Eucommia ulmoides leaves (EUL) on growth performance and antioxidant status of growing rabbits under heat stress condition.
Song Li, Miaoqing Zhao, Tingting Jiang, Wenwen Lv, Shujuan Gao, Yufa Zhou, Zengmin Miao   +6 more
doaj   +1 more source

Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome. [PDF]

, 2015
Beans (Phaseolus vulgaris) contain bioactive components with functional properties that may modify cardiovascular risk. The aims of this pilot study were to evaluate the ability of black beans to attenuate postprandial metabolic, oxidative stress, and ...
Burton-Freeman, Britt M, Edirisinghe, Indika, Kappagoda, C Tissa, Randolph, Jody M, Reverri, Elizabeth J, Steinberg, Francene M   +5 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effects of Dietary Rumen‐Protected Choline on Stress Alleviation, Antioxidant Modulation, and Haematological, Immunological, and Offspring Performance in Transitioning Goats

Veterinary Medicine and Science
The transition period is a crucial time for dairy animals, marked by significant physiological changes. This study investigated the effects of supplementing rumen‐protected choline (RPC) on oxidative stress, immune function, liver health and performance ...
Mohammad Asadi, Mostafa Bokharaeian, Homa Mohammadi Fard   +2 more
doaj   +1 more source

Oxidant/Antioxidant Status Is Impaired in Sepsis and Is Related to Anti-Apoptotic, Inflammatory, and Innate Immunity Alterations

Antioxidants, 2022
Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis.
Marianna Miliaraki, Panagiotis Briassoulis, Stavroula Ilia, Kalliopi Michalakakou, Theodoros Karakonstantakis, Aikaterini Polonifi, Kalliopi Bastaki, Efrossini Briassouli, Konstantinos Vardas, Aikaterini Pistiki, Maria Theodorakopoulou, Theonymfi Tavladaki, Anna-Maria Spanaki, Eumorfia Kondili, Helen Dimitriou, Maria Venihaki, Sotirios Tsiodras, Dimitrios Georgopoulos, Marina Mantzourani, Serafeim Nanas, Apostolos Armaganidis, George L. Daikos, Ioannis Papassotiriou, George Briassoulis   +23 more
doaj   +1 more source

Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism [PDF]

, 2016
Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis.
Abruzzese, Giselle Adriana, Ferreira, Silvana Rocío, Heber, María Florencia, Motta, Alicia Beatriz, Pignataro, Omar Pedro, Reynoso, Roxana María, Velez, Leandro Martin   +6 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Impact of Effective Probiotic Microorganisms (EPMs) on Growth Performance, Hematobiochemical Panel, Immuno-Antioxidant Status, and Gut Cultivable Microbiota in Striped Catfish (Pangasianodon hypophthalmus)

Fishes
Striped catfish, Pangasianodon hypophthalmus, has recently emerged as a promising candidate for Egyptian aquaculture owing to its rapid growth; however, under intensive culture, it is vulnerable to Aeromonas hydrophila.
Mahmoud Abdullah Elnakeeb, Ahmed Mohamed Ashry, Ahmed Mohamed El-Zayat, Abdel Wahab Abdel-Moez Abdel-Warith, Mahmoud Mohamed Habiba, Elsayed Mohamed Ibrahim Younis, Simon John Davies, Ibrahim Mohamed Ibrahim, Fatma Elzhraa, Ahmed Mohammed El-Sebaey   +9 more
doaj   +1 more source

Effect of Bamboo Leaf Extract on Antioxidant Status and Cholesterol Metabolism in Broiler Chickens

Animals, 2019
The objective of this study was to investigate the effects of dietary bamboo leaf extract (BLE) on antioxidant status and cholesterol metabolism in broilers. One-day-old male Arbor Acres (576) broilers were randomly divided into six groups.
Mingming Shen, Zechen Xie, Minghui Jia, Anqi Li, Hongli Han, Tian Wang, Lili Zhang   +6 more
doaj   +1 more source