Results 61 to 70 of about 495,387 (365)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
FishesStriped catfish, Pangasianodon hypophthalmus, has recently emerged as a promising candidate for Egyptian aquaculture owing to its rapid growth; however, under intensive culture, it is vulnerable to Aeromonas hydrophila.
Mahmoud Abdullah Elnakeeb +9 more
doaj +1 more source
Effect of Bamboo Leaf Extract on Antioxidant Status and Cholesterol Metabolism in Broiler Chickens
Animals, 2019 The objective of this study was to investigate the effects of dietary bamboo leaf extract (BLE) on antioxidant status and cholesterol metabolism in broilers. One-day-old male Arbor Acres (576) broilers were randomly divided into six groups.
Mingming Shen +6 more
doaj +1 more source
Animals, 2022 Cold climates may be a risk to the health and welfare of lambs during winter because cold environments alter the physiological processes of lambs, and we used cold environments with three different temperature gradients—an indoor heating control group ...
Lulu Shi +7 more
doaj +1 more source
Antioxidant Supplementation in the Treatment of Aging-Associated Diseases [PDF]
, 2016 Oxidative stress is generally considered as the consequence of an imbalance between pro- and antioxidants species, which often results into indiscriminate and global damage at the organismal level.
Conti, V +7 more
core +2 more sources
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]
, 2020 Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A. +6 more
core +1 more source
Glaucoma and Antioxidant Status
, 2014 Glaucoma, one of the leading causes of irreversible blindness in the world, is defined as a slowly progressive optic neuropathy characterized by retinal nerve fiber and visual field loss. Although increased intraocular pressure is the major risk factor for glaucoma, other risk factors include advanced age, genetic predisposition, family history, gender,
Tosun, Mehmet +2 more
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress
International Journal of Integrated Health SciencesBackground: Hypothyroidism is frequently associated with anemia and oxidative stress, necessitating exploration of biomarkers like Osteopontin to better understand disease mechanisms.
Sumesh Prasad Sah +5 more
doaj +1 more source
Italian Journal of Animal Science, 2021 The aim of this study was to determine the effect of vitamin E (α-Toc) and Otostgia persica leaf extract (OPLE) on the performance, immune response, and oxidative status in broiler chicken fed oxidised oil.
Saeid Jafari +2 more
doaj +1 more source