Results 71 to 80 of about 587,425 (309)

Novel perspectives in redox biology and pathophysiology of failing myocytes: modulation of the intramyocardial redox milieu for therapeutic interventions - A review article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology [PDF]

, 2016
The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogeneticmechanisms and in developing effective therapies that have transformed this ...
Angelini, Annalisa, Arcaro, Alessia, Chimenti, Cristina, Crotti, Lia, Giordano, Carla, Mancardi, Daniele, Pirozzi, Flora, Tocchetti, Carlo G., Torella, Daniele   +8 more
core   +5 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Antioxidant properties of cashew leaves' extracts before and after treatment with activated carbon used in cosmetics [PDF]

, 2011
Natural ingredients such as cashew leaves extract could be an attractive candidate in cosmetic formulation. However, the plant extracts are normally dark brown and greenish color that might spoil the appearance of the products if they are added in ...
Abd. Majid, Fadzilah Adibah, Chermahini, Siavash Hosseinpour, Sarmidi, Mohamad Roji   +2 more
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Protective Effect of Lemon (Citrus Limon L.) Ethanol Extract Cream as an Antioxidant Against Exposure to Ultraviolet B Rays in the Skin of Male Wistar (Rattus Norvegicus) Rats [PDF]

, 2020
Background: Indonesia is an archipelagic country and one of the tropical countries that get sun exposure all the time. Sun exposure can have beneficial and detrimental effects in life. Exposure to radiation can cause acute effects in the form of erythema
Dewanti, D. A. (Dewa), Dewi, N. W. (Ni), Ernawati, D. K. (Desak), Indrayani, A. W. (Agung), Jawi, I. M. (I)   +4 more
core  

The Antioxidant Potential of the Mediterranean Diet in Patients at High Cardiovascular Risk: An In-Depth Review of the PREDIMED [PDF]

, 2018
Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of ...
A Bach-Faig, A Ceriello, A Medina-Remón, A Medina-Remón, A Medina-Remón, A Medina-Remón, A Scalbert, A Scalbert, A Sureda, A Sánchez-Villegas, A Tresserra-Rimbau, A Tresserra-Rimbau, A Tresserra-Rimbau, A Tresserra-Rimbau, A Trichopoulou, B Poljsak, BW Tassell Van, C Borek, C Feart, C Manach, C Razquin, C Vilaplana-Pérez, CC Chuang, D Mozaffarian, D Rio Del, E Couto, E Miró-Casas, E Toledo, E Tripoli, EJ Benjamin, FB Hu, FM Sacks, G Bjelakovic, G Flores-Mateo, G Michas, H Zhang, J Salas-Salvadó, J Vinson, KB Pandey, KT Howitz, LA Pham-Huy, LJ Appel, M Fandos, M Guasch-Ferré, M Guasch-Ferré, M Guasch-Ferré, MA Martínez-González, MA Martínez-González, MAacute Martínez-González, MG Hertog, P Henríquez-Sánchez, P Libby, P Libby, PM Clarkson, R Carnevale, R Estruch, R Micha, RM Ortega, S Ashfaq, S Padayatty, S Rautiainen, V Benetou, V Konstantinidou, WC Willett, WJ Dahl, X Guo   +65 more
core   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Natural Antioxidants for Food Applications : Challenges and Recent Developments [PDF]

, 2017
Peer reviewedPublisher ...
Raikos, Vasileios
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source