Results 131 to 140 of about 5,494 (181)

The antiplasmodial activity of norcantharidin analogs

Bioorganic & Medicinal Chemistry Letters, 2010
The antiplasmodial activities of sixty norcantharidin analogs were tested in vitro against a chloroquine sensitive (D6, Sierra Leone) and chloroquine resistant (W2) strains of Plasmodium falciparum. Forty analogs returned IC(50) values
Bajsa, Joanna, McCluskey, Adam, Gordon, Christopher P. (R17840), Stewart, Scott G., Hill, Timothy A., Sahu, Rajnish, Duke, Stephen O., Tekwani, Babu L.   +7 more
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Antiplasmodial activity of Cylicodiscus gabunensis

Journal of Ethnopharmacology, 2006
The antimalarial activity of ethanolic stembark extract of Cylicodiscus gabunensis was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections as well as for repository activity. The LD(50) of the extract was determined to be 223.6 mg/kg, while doses of 250 mg/kg and above were found to be lethal to mice.
Jude E, Okokon, Basil N, Ita, Aniekan E, Udokpoh   +2 more
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Antiplasmodial activity of piperazine sulfonamides

Bioorganic & Medicinal Chemistry Letters, 2010
A high-throughput screening program identified two piperazine sulfonamides with activity against Plasmodium falciparum. Both screening positives had three structural features with potential liabilities: furanyl, thiourea and nitrophenyl groups. The furan could be replaced with no loss of activity, replacement of the nitrophenyl led to some loss of ...
Derek C, Martyn, Joseph F, Cortese, Erin, Tyndall, Justin, Dick, Ralph, Mazitschek, Benito, Munoz, Jon, Clardy   +6 more
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Antiplasmodial Activity of Mono- and Dimeric Carbazoles

Planta Medica, 1998
A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml.
Bringmann, G., Ledermann, A., Holenz, J., Kao, M.-T., Busse, U., Wu, H.G., François, G.   +6 more
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Novel antiplasmodial agents

Medicinal Research Reviews, 2003
AbstractThe morbidity and mortality associated with malaria have spurred efforts to find novel antimalarial agents with improved potency and selectivity. Leads for agents continue to be obtained from natural sources (plants and microorganisms) and chemical syntheses.
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Highly Potential Antiplasmodial Restricted Peptides

Chemical Biology & Drug Design, 2014
Malaria is an infectious disease responsible for approximately one million deaths annually. The antimalarial effects of angiotensinIIand its analogs againstPlasmodium gallinaceumandP. falciparumhave recently been reported. To evaluate antiplasmodial activity, we synthesized five angiotensinII‐restricted analogs containing disulfide bridges.
Torres, Marcelo Der Torossian, Adriana F, Silva, Flávio L, Alves, Margareth L, Capurro, Antonio, Miranda, Oliveira, Vani Xavier   +5 more
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Antiplasmodial activity and cytotoxicity of Albertisia delagoensis

Fitoterapia, 2007
Leaves and rhizome methanol extracts of Albertisia delagoensis tested positive against Plasmodium falciparum, with a very low cytotoxic activity in leaves against the Graham cell line.
Helene, De Wet, Fanie R, Van Heerden, Ben-Erik, Van Wyk, Robyn L, Van Zyl   +3 more
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Synthesis and antiplasmodial activity of lycorine derivatives

Bioorganic & Medicinal Chemistry, 2010
Twenty seven lycorine derivatives were prepared and evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum. The best antiplasmodial activities were achieved with lycorine derivatives that present free hydroxyl groups at C-1 and C-2 or esterified as acetates or isobutyrates.
Juan C, Cedrón, David, Gutiérrez, Ninoska, Flores, Angel G, Ravelo, Ana, Estévez-Braun   +4 more
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The Fungal Metabolites with Potential Antiplasmodial Activity

Current Medicinal Chemistry, 2018
Malaria caused by Plasmodium parasites is amongst many prevalent public health concerns in several tropical regions of the world. Nowadays, the parasite resistance patterns to most currently used drugs in therapy and insecticides have created an urgent need for new chemical entities exhibiting new modes of action and management strategies. Fungus has
Bin, Yang, Jingxia, Huang, Xuefeng, Zhou, Xiuping, Lin, Juan, Liu, Shengrong, Liao, Junfeng, Wang, Feng-An, Liu, Huaming, Tao, Yonghong, Liu   +9 more
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Antiplasmodial activity of Aspidosperma indole alkaloids

Phytomedicine, 2002
The antiplasmodial activity of twelve alkaloids with an aspidospermane skeleton was estimated in vitro on chloroquine-resistant and sensitive strains of Plasmodium falciparum. Seven tetracyclic alkaloids possessing a free ethyl chain such aspidospermine, showed IC50 after incubation for 72 h between 3.2 and 15.4 microM.
A C, Mitaine-Offer, M, Sauvain, A, Valentin, J, Callapa, M, Mallié, M, Zèches-Hanrot   +5 more
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