Results 141 to 150 of about 5,494 (181)

Clofazimine analogs with antileishmanial and antiplasmodial activity

Bioorganic & Medicinal Chemistry, 2015
A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes.
A. Barteselli, M. Casagrande, N. Basilico, S. Parapini, C.M. Rusconi, M. Tonelli, V. Boido, D. Taramelli, F. Sparatore, A. Sparatore   +9 more
openaire   +2 more sources

Antiplasmodial activity of Homalium letestui

Phytotherapy Research, 2006
AbstractThe in vivo antiplasmodial activity of the ethanol root extract of Homalium letestui used as a malaria remedy in Southern Nigeria was evaluated in Plasmodium berghei berghei infected mice. Homalium letestui root extract (500–1000 mg/kg/day) exhibited significant (p < 0.05) blood schizontocidal activities both in a 4‐day early infection test ...
Jude E, Okokon, Basil, Ita, Aniekan E, Udokpoh   +2 more
openaire   +2 more sources

Antiplasmodial constituents of Cajanus cajan

Phytotherapy Research, 2004
AbstractBioactivity‐guided fractionation of extracts of roots and leaves of Cajanus cajan afforded 8 compounds: betulinic acid, biochanin A, cajanol, genistein and 2′‐hydroxygenistein, longistylin A and C, and pinostrobin. The two stilbenes, longistylin A and C, and betulinic acid showed a moderately high in vitro activity against the chloroquine ...
Duker-Eshun, George, Jaroszewski, Jerzy W., Asomaning, William A., Oppong-Boachie, Francis, Christensen, S. Brøgger   +4 more
openaire   +3 more sources

Prenylated Xanthones as Potential Antiplasmodial Substances

Planta Medica, 2006
Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-
Wilawan, Mahabusarakam, Kunnika, Kuaha, Prapon, Wilairat, Walter C, Taylor   +3 more
openaire   +2 more sources

Antiplasmodial and Antitrypanosomal Activity of Pyrethrins and Pyrethroids

Journal of Agricultural and Food Chemistry, 2011
In a screen of 1800 plant and fungal extracts for antiplasmodial, antitrypanosomal, and leishmanicidal activity, the n-hexane extract of Chrysanthemum cinerariifolium (Trevir.) Vis. flowers showed strong activity against Plasmodium falciparum. We isolated the five pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and
Hata, Y., Zimmermann, S., Quitschau, M., Kaiser, M., Brun, R., Hamburger, M., Adams, M.   +6 more
openaire   +4 more sources

Quinoline hybrids and their antiplasmodial and antimalarial activities

European Journal of Medicinal Chemistry, 2017
Malaria, in particular infection with P. falciparum (the most lethal of the human malaria parasite species, responsible for nearly one million deaths every year), is one of the most devastating and common infectious disease throughout the world. Beginning with quinine, quinoline containing compounds have long been used in clinical treatment of malaria ...
Yuan-Qiang, Hu, Chuan, Gao, Shu, Zhang, Lei, Xu, Zhi, Xu, Lian-Shun, Feng, Xiang, Wu, Feng, Zhao   +7 more
openaire   +2 more sources

Antiplasmodial activity of Setaria megaphylla

Phytotherapy Research, 2007
AbstractThe antimalarial activity of an ethanol leaf extract of Setaria megaphylla was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections. Setaria megaphylla (100–300 mg/kg/day) exhibited a significant (p < 0.05) blood schizonticidal activity in 4‐day early infection and in established infection ...
Jude E, Okokon, Peace M E, Ubulom, Aniekan E, Udokpoh   +2 more
openaire   +2 more sources

Triazole derivatives and their antiplasmodial and antimalarial activities

European Journal of Medicinal Chemistry, 2019
Malaria, caused by protozoan parasites of the genus Plasmodium especially by the most prevalent parasite Plasmodium falciparum, represents one of the most devastating and common infectious disease globally. Nearly half of the world population is under the risk of being infected, and more than 200 million new clinical cases with around half a million ...
Xue-Mei, Chu, Cong, Wang, Wen-Ling, Wang, Li-Li, Liang, Wen, Liu, Kai-Kai, Gong, Kun-Lai, Sun   +6 more
openaire   +2 more sources

Antiplasmodial Alkaloids from Desmos rostrata

Journal of Natural Products, 2008
Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7).
Nguyen, Ngoc Tuan, Pham, van Cuong, Litaudon, Marc, Guéritte, Françoise, Grellier, Philippe, Nguyen, van Tuyen, Nguyen, van Hung   +6 more
openaire   +3 more sources

Antiplasmodial Activity of the Alkaloids ofPeschiera fuchsiaefolia

Planta Medica, 2009
The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant.
E. Federici, G. Palazzino, NICOLETTI, Marcello, C. Galeffi   +3 more
openaire   +3 more sources