Antiproliferative Activity of Fucan Nanogel [PDF]
Marine Drugs, 2012 Sulfated fucans comprise families of polydisperse natural polysaccharides based on sulfated l-fucose. Our aim was to investigate whether fucan nanogel induces cell-specific responses.
Francisco Miguel Gama +8 more
doaj +8 more sources
Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs [PDF]
Marine Drugs, 2018 Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also ...
Abdullah Faisal Aldairi +2 more
doaj +4 more sources
Phytochemical compounds, antioxidant activity, and antiproliferative activity of sesame seeds as affected by simulated digestion [PDF]
Food Chemistry: XAntioxidant and antiproliferative activities in white and black sesame seeds were investigated during a simulated in vitro digestion. The levels of phenolic compounds, flavonoids and oxygen radical absorbance capacity (ORAC) values of sesame seeds ...
Lin Zhou +6 more
doaj +2 more sources
Biological Activity Survey of Pereskia aculeata Mill. and Pereskia grandifolia Haw. (Cactaceae) [PDF]
Pharmaceutical Sciences, 2022 Background: Pereskia aculeata and P. grandifolia are non-traditional Brazilian vegetables with high nutritional value used in traditional medicine.
Adriana Muniz Massocatto +7 more
doaj +1 more source
The cancer preventive activity and mechanisms of prenylated resveratrol and derivatives
Current Research in Toxicology, 2023 Resveratrol is regarded as neutraceuticals with multiple health benefits. The introduction of prenyl can enhance the bioactivity. In this work, the cancer preventive activities and mechanisms of 18 prenylated reseveratrol and derivatives were ...
Ting Zhou +3 more
doaj +1 more source
Antiproliferative and apoptosis-inducing properties of selected medicinal plants of Assam, India
Archives of Medicine and Health Sciences, 2021 Background and Aim: Ethnomedicine is a common practice of disease treatment among tribal communities of India. The present study investigated the antiproliferative and apoptosis-inducing activities of seven medicinal plants traditionally used by the Bodo
Mritunjoy Kumar Roy +2 more
doaj +1 more source
New Tripentone Analogs with Antiproliferative Activity [PDF]
Molecules, 2017 Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar range. New tripentone analogs, in which a pyridine moiety replaces the thiophene ring originating the fused azaindole system endowed with anticancer activity viz 8H-thieno[2,3-b]pyrrolizinones, were
Barbara Parrino +9 more
openaire +4 more sources
Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity [PDF]
Marine Drugs, 2010 Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their ...
Simon-Levert, Annabel +6 more
openaire +3 more sources
Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells. [PDF]
PLoS ONE, 2016 In our continuing structure-activity relationship study of a new class of erythromycin A (EM-A) derivatives with antiproliferative activity, a new series of de(N-methyl) EM-A dimers jointed by a four-atom linker, -CH2CH = CHCH2-, were prepared and their ...
Lan Wu +7 more
doaj +1 more source
Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]
, 2013 Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Badura, Susanne +8 more
core +6 more sources