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Antiproliferative and Cytotoxic Activities
2018Cancer is a genetic disease, affecting many people worldwide. Chemotherapy is routinely used for cancer treatment. However, this therapeutic approach is not always effective due to the development of cell resistance and toxic effects. Plants are a reservoir of natural chemicals with chemoprotective potential against cancer and with low adverse effects.
Anesini, Claudia Alejandra +2 more
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Antiproliferative Activity of Cobra Venom Cytotoxins
Current Topics in Medicinal Chemistry, 2015Cytotoxins (or cardiotoxins, CTs) are small rigid membrane-active proteins of the three-finger toxin (TFT) family. They comprise about 60 amino acid residues, stabilized by four disulphide bridges. CTs, the most abundant proteins in cobra venom are able to kill cancer cells in a dose and time-dependent manner.
Peter V, Dubovskii, Yuri N, Utkin
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Antiangiogenic and antiproliferative activity of suramin analogues
Cancer Chemotherapy and Pharmacology, 1997The purpose of this study was to test the ability of 70 polyanionic analogues of suramin to inhibit angiogenesis. The ID50, the dose that produced 50% inhibition of angiogenesis, was determined for suramin and each of the analogues by measuring the ability of various amounts to inhibit angiogenesis in vivo in the chick egg chorioallantoic membrane (CAM)
A R, Gagliardi +5 more
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Anticancer and antiproliferative activity of natural brassinosteroids
Phytochemistry, 2008Brassinosteroids (BRs) are steroid plant hormones that are essential for many plant growth and developmental processes, including cell expansion, vascular differentiation and stress responses. Up to now the inhibitory effects of BRs on cell division of mammalian cells are unknown.
Jana, Malíková +3 more
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Fungal Proteins with Antiproliferative and Anticancer Activities
Protein & Peptide Letters, 2013Fungi produce a variety of proteins with antiproliferative activity toward tumor cells and anticancer activity in tumor bearing mice. The aforementioned fungal proteins include ribonucleases, antifungal proteins, ubiquitin-like peptides, ribosome inactivating proteins, hemolysins, hemagglutinins/lectins, laccases, and protein-bound polysaccharopeptides.
T B, Ng, J H, Wong
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Antiproliferative activity of salinomycin and its derivatives
Bioorganic & Medicinal Chemistry Letters, 2012Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines.
Adam, Huczyński +5 more
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Enhancement of antiproliferative activity by phototautomerization of anthrylphenols
Photochemical & Photobiological Sciences, 2015An antiproliferative investigation was conducted on 3 human cancer cell lines, HCT 116 (colon), MCF-7 (breast), and H 460 (lung), on a series of 4 anthrylphenols in the dark and upon exposure to light (350 nm). 9-(2-Hydroxyphenyl)anthracene (1) moderately inhibited proliferation, but irradiation considerably enhanced the effect. The other anthracenes 4–
Marijeta Kralj +7 more
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Antiproliferative activities of tea and herbal infusions
Food & Function, 2013The consumption of tea and herbal infusions has increased rapidly in recent years. More and more people consume these infusions as daily beverages as well as for health purposes. The aim of this study was to supply new information on the antiproliferative function of these infusions for nutritionists and the general public.
Fang, Li +5 more
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Antioxidant and Antiproliferative Activities of Common Vegetables
Journal of Agricultural and Food Chemistry, 2002Epidemiological studies have shown that consumption of fruits and vegetables is associated with reduced risk of chronic diseases. Increased consumption of fruits and vegetables containing high levels of phytochemicals has been recommended to prevent chronic diseases related to oxidative stress in the human body. In this study, 10 common vegetables were
Yi-Fang, Chu +3 more
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Synthesis and antiproliferative activity of 6-phenylaminopurines
European Journal of Medicinal Chemistry, 2014A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring different groups at positions 2, 8 and 9 of the purine ring and at the exocyclic nitrogen atom at position 6. Among the newly described purines, five compounds showed antiproliferative activity with IC50 values below 10 μM, the tetrahydroquinoline derivative ...
María-Dolores Canela +4 more
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