Results 181 to 190 of about 16,319 (219)

Antiprotozoal activity of Betulinic acid derivatives

Phytomedicine, 2010
Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity.
D B, Domínguez-Carmona, F, Escalante-Erosa, K, García-Sosa, G, Ruiz-Pinell, D, Gutierrez-Yapu, M J, Chan-Bacab, A, Giménez-Turba, L M, Peña-Rodríguez   +7 more
openaire   +2 more sources

Antiprotozoal activities of symmetrical bishydroxamic acids

Bioorganic & Medicinal Chemistry, 2003
Symmetrical bishydroxamic acids along with their sodium salts containing an alkyl spacer between two aromatic rings were synthesized, and their antiparasitic activities were evaluated. Bishydroxamic acids were conveniently prepared from the alkylation of methyl 4-hydroxybenzoate with various dihalo-alkane, -alkene, and -ether followed by reaction with ...
Duy H, Hua, Masafumi, Tamura, Masahiro, Egi, Karl, Werbovetz, Dawn, Delfín, Manar, Salem, Peter K, Chiang   +6 more
openaire   +2 more sources

8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity

Journal of Natural Products, 2012
Semisynthetic 8,8-dialkyldihydroberberines (8,8-DDBs) were found to possess mid- to low-nanomolar potency against Plasmodium falciparum blood-stage parasites, Leishmania donovani intracellular amastigotes, and Trypanosoma brucei brucei bloodstream forms.
Endeshaw, Molla, Zhu, Xiaohua, He, Shanshan, Pandharkar, Trupti, Cason, Emily, Mahasenan, Kiran V., Agarwal, Hitesh, Li, Chenglong, Munde, Manoj, Wilson, W. David, Bahar, Mark, Doskotch, Raymond W., Kinghorn, A. Douglas, Kaiser, Marcel, Brun, Reto, Drew, Mark E., Werbovetz, Karl A.   +16 more
openaire   +3 more sources

Antiprotozoal activity of proton-pump inhibitors

Bioorganic & Medicinal Chemistry Letters, 2011
Parasitic diseases are still a major health problem in developing countries. In our effort to find new antiparasitic agents, in this Letter we report the in vitro antiprotozoal activity of omeprazole, lansoprazole, rabeprazole and pantoprazole against Trichomonas vaginalis, Giardia intestinalis and Entamoeba histolytica. Molecular modeling studies were
Jaime, Pérez-Villanueva, Antonio, Romo-Mancillas, Alicia, Hernández-Campos, Lilián, Yépez-Mulia, Francisco, Hernández-Luis, Rafael, Castillo   +5 more
openaire   +2 more sources

Antiprotozoal activity of chloroquinoline based chalcones

European Journal of Medicinal Chemistry, 2011
A new series of chloroquinoline based chalcones were synthesized and evaluated for in vitro antiamoebic and antimalarial activities. The results showed that out of fifteen compounds, four were found to be more active against the Entamoeba histolytica; while one compound was moderatively active compared to the standard drug metronidazole (IC50=1.46 μM).
Faisal, Hayat, Emma, Moseley, Attar, Salahuddin, Robyn L, Van Zyl, Amir, Azam   +4 more
openaire   +2 more sources

Antiprotozoal and Anthelmintic Activity of Zinc Oxide Nanoparticles

Current Medicinal Chemistry, 2022
: Nanomaterials represent a wide alternative for the treatment of several diseases that affect both human and animal health. The use of these materials consists, mainly, in trying to solve the problem of resistance that pathogenic organisms acquire to conventional drugs.
José Rodrigues do Carmo Neto, Rhanoica Oliveira Guerra, Juliana Reis Machado, Anielle Christine Almeida Silva, Marcos Vinicius da Silva   +4 more
openaire   +2 more sources

Macrophage Activation: Enhanced Oxidative and Antiprotozoal Activity

1984
Although only one of the array of secretory properties displayed by activated macrophages, the capacity to generate increased amounts of reactive oxygen intermediates is a consistent biochemical marker of activation with clearly relevant biologic effects (Nathan et al., 1980).
openaire   +2 more sources

Bicyclic amido compounds with antiprotozoal activity

Monatshefte für Chemie - Chemical Monthly, 2009
Aroyl derivatives of 2-aminobicyclo-octanes and 2-azabicyclo-nonanes have been synthesized and tested for their activities against the causative organisms of East African trypanosomiasis and malaria tropica. The acylation induced in general loss of antiprotozoal activity, but a single compound showed good antiplasmodial activity against a ...
Faist, J., Seebacher, W., Kaiser, M., Brun, R., Saf, R., Weis, R.   +5 more
openaire   +1 more source

Synthesis and Antiprotozoal Activity of Cationic 2-Phenylbenzofurans

Journal of Medicinal Chemistry, 2008
A series of cationically substituted 2-phenylbenzofurans 1- 49 have been synthesized, and their in vitro antiprotozoal properties against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, as well as cytotoxicity against mammalian cells, have been evaluated.
Stanislav A, Bakunov, Svetlana M, Bakunova, Tanja, Wenzler, Todd, Barszcz, Karl A, Werbovetz, Reto, Brun, Richard R, Tidwell   +6 more
openaire   +2 more sources

Natural Products with Antiprotozoal Activity

1999
Protozoal diseases are a major threat to the health of human populations and domestic animals worldwide, mainly due of the absence of vaccines and deficiencies in chemotherapy and vector control. Although chemotherapy has played a major role in the treatment and control of protozoal diseases since the pioneering work of Ehrlich at the beginning of the ...
S. L. Croft, C. R. Weiss
openaire   +1 more source