Results 51 to 60 of about 8,118 (201)

A Crystalline and Thermally Stable Selenocysteine Selenenic Acid

Angewandte Chemie International Edition, EarlyView.
The long‐sought catalytic intermediate of selenoproteins, selenocysteine selenenic acid (Sec–SeOH), is isolated for the first time at ambient temperature. A bioinspired selenopeptide sequence encapsulated within a protective molecular cradle and an oxidant‐free route from selenenyl iodide (Sec–SeI) enable the isolation of Sec–SeOH. Contrary to the long‐
Ryosuke Masuda, Satoru Kuwano, Kei Goto
wiley   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials

, 2007
OBJECTIVE: To determine the effect of adjunctive antithyroid drugs on the risk of treatment failure, hypothyroidism, and adverse events after radioiodine treatment. DESIGN: Meta-analysis.
Cooper, D. S., Muller-Brand, J, Walter, M. A., Connell, J, Walter, MA, Bonnema, SJ, Bucher, H. C., Bonnema, S. J., Muller, B, Bonnema, Steen J, Bucher, Heiner C, Walter, Martin A, Muller-Brand, J., Muller, B., Cooper, DS, Christ-Crain, Mirjam, Briel, M., Cooper, David S, Christ-Crain, M, Bucher, HC, Connell, J., Müller-Brand, Jan, Briel, Matthias, Briel, M, Müller, Beat, Connell, John M, Christ-Crain, M.   +26 more
core   +1 more source

Methimazole-Induced neutropenic gingival ulcerations and necrosis in a middle-aged female: A case report with clinical management

Journal of Mid-Life Health, 2018
One of the major manifestations of methimazole-induced neutropenia or agranulocytosis is diffuse gingival ulceration and necrosis. The aim of this case report is to be familiar with drug-induced neutropenia and its associated oral manifestations and the ...
Ritika Arora, Anamika Sharma, Deepakshi Dimri, Himani Sharma   +3 more
doaj   +1 more source

Maternal Thyroid Diseases, Medication Use and Childhood Cancer Risks in Offspring: A Population‐Based Cohort Study in Denmark

International Journal of Cancer, EarlyView.
Thyroid diseases are common among women of reproductive age and may be related to childhood cancer, but the evidence is inconsistent. This study of childhood cancer with maternal thyroid diseases and medication use in a population‐based case‐control study using Danish registries found positive associations between maternal goiter and overall cancer ...
Chuanjie Deng, Kosuke Inoue, Chai Saechao, Johnni Hansen, Beate Ritz, Julia E. Heck   +5 more
wiley   +1 more source

Prediction of response to medical therapy by serum soluble (pro)renin receptor levels in Graves' disease.

PLoS ONE, 2018
Antithyroid drugs are generally selected as the first-line treatment for Graves' Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR]
Yuki Mizuguchi, Satoshi Morimoto, Shihori Kimura, Noriyoshi Takano, Kaoru Yamashita, Yasufumi Seki, Kanako Bokuda, Midori Yatabe, Junichi Yatabe, Daisuke Watanabe, Takashi Ando, Atsuhiro Ichihara   +11 more
doaj   +1 more source

Relapse Rate and Clinical Risk Factors Affecting the Treatment of Graves’ Disease

Siriraj Medical Journal, 2021
Objective: To determine the relapse rate of Graves’ disease (GD) and identify important clinical risk factors for relapse. Materials and Methods: This was a 10-year retrospective cohort study.
Phatharaporn Kiatpanabhikul
doaj   +1 more source

What Endocrinologists Should Know About Iodine: Population Deficiency, Individual Excess and Misinformation in the United Kingdom

Clinical Endocrinology, EarlyView.
ABSTRACT Iodine deficiency, once considered eliminated in the United Kingdom, has re‐emerged, particularly among women of reproductive age, in whom requirements are increased during pregnancy and lactation. The declining consumption of dairy and white fish, the emerging use of unfortified plant‐based milk alternatives, and the absence of a national ...
Peter N. Taylor, Malcolm Prentice, Sarah Bath, Emilie Combet, Nadia Schoenmakers, Vicki E. Smith, Fraser W. Gibb, Nicola Zammitt, Onyebuchi Okosieme, Kristien Boelaert, John Lazarus, Mark Vanderpump   +11 more
wiley   +1 more source

Hyperthyroidism in pregnancy: evidence and hypothesis in fetal programming and development

Endocrine Connections, 2021
The management of hyperthyroidism in pregnant patients has been a topic of raised clinical awareness for decades. It is a strong recommendation that overt hyperthyroidism of Graves’ disease in pregnant women should be treated to prevent complications ...
Stine Linding Andersen, Stig Andersen
doaj   +1 more source

Thyroid Hemiagenesis Associated with Hashimoto’s Thyroiditis

Case Reports in Endocrinology, 2013
Thyroid hemiagenesis is a rare congenital anomaly resulting from failure of one thyroid lobe development. We report a 23-year-old female presented with Hashimoto’s thyroiditis in left lobe, associated with hemiagenesis of right lobe and isthmus which ...
D. Nsame, A. Chadli, L. Hallab, S. El Aziz, H. El Ghomari, A. Farouqi   +5 more
doaj   +1 more source