Results 121 to 130 of about 3,270,661 (190)

In vitro and in silico exploration of newly synthesized triazolyl- isonicotinohydrazides as potent antitubercular agents

Journal of Biomolecular Structure and Dynamics, 2023
In the present study, we have reported the synthesis of novel isoniazid-triazole derivatives (4a-r), via the click chemistry approach. The synthesized isoniazid-triazole derivatives have potent in vitro antitubercular activity against the Mycobacterium ...
Rajubai D. Bakale, Pramod S. Phatak, Sanket Rathod, Prafulla B. Choudhari, E. M. Rekha, D. Sriram, R. Kulkarni, K. Haval   +7 more
semanticscholar   +1 more source

Design, synthesis, computational molecular docking studies of novel heterocyclics bearing 1,2,4–triazole, 1,3,4–oxadiazole conjugates as potent antibacterial and antitubercular agents

Journal of Biomolecular Structure and Dynamics, 2023
Herein, we report the synthesis, and characterization of a new series of 1,3,4–oxadiazole and 1,2,4–triazole derivatives based on azaindole acetamides and assigned as potential antibacterial and antitubercular substances.
B. Sravanthi, G. Himavathi, A. R. Robert, P. Karunakar, K. Kiran, S. Maddila   +5 more
semanticscholar   +1 more source

Thiazole Heterocycle: An Incredible and Potential Scaffold in Drug Discovery and Development of Antitubercular Agents

ChemistrySelect, 2023
In 2020, 15 million people were diagnosed with tuberculosis (TB), and 2.4 million died. Additionally, the TB situation is worse with multidrug resistance (MDR) and extended‐drug resistance (XDR)‐TB.
Neeru Bhanwala, Vaibhav Gupta, Lokesh Chandrakar, Gopal L. Khatik   +3 more
semanticscholar   +1 more source

Docking Simulations and Primary Assessment of Newly Synthesized Benzene Sulfonamide Pyrazole Oxadiazole Derivatives as Potential Antimicrobial and Antitubercular Agents

Polycyclic aromatic compounds (Print), 2022
A novel series of benzene sulfonamide pyrazole oxadiazole derivatives have been synthesized by reaction of 4-(5-(3-fluoro-4-methoxyphenyl)-3-(hydrazinecarbonyl)-1H-pyrazol-1-yl) benzene sulfonamide with different substituted benzoic/pyridinyl/indolyl ...
Ramesh M. Shingare, Yogesh S. Patil, J. Sangshetti, R. Patil, D. Rajani, Balaji R. Madje   +5 more
semanticscholar   +1 more source

Synthesis and in vitro studies for structure-based design of novel chalcones as antitubercular agents targeting InhA.

Future Medicinal Chemistry, 2022
Background: The authors aimed to estimate the therapeutic potential of novel chalcones against tuberculosis. Methods: 11 synthesized compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis (H37RV; American Type ...
L. S. Dhivya, B. R. Pradeepa, S. Sarvesh
semanticscholar   +1 more source

Exploration of Isoxazole‐Carboxylic Acid Methyl Ester Based 2‐Substituted Quinoline Derivatives as Promising Antitubercular Agents

Chemistry and Biodiversity, 2022
In pursuit of potent anti‐TB agents active against drug resistant tuberculosis (DR‐TB), herein we report synthesis and bio‐evaluation of a new series of isoxazole‐carboxylic acid methyl ester based 2‐substituted quinoline derivatives.
Santosh Kumar Sahoo, Mohammad Naiyaz Ahmad, Grace Kaul, Srinivas Nanduri, A. Dasgupta, S. Chopra, Venkata Madhavi Yaddanapudi   +6 more
semanticscholar   +1 more source

QcrB in Mycobacterium tuberculosis: The new drug target of antitubercular agents

Medicinal research reviews (Print), 2021
Drug‐resistance in mycobacterial infections is a major global health problem that leads to high mortality and socioeconomic pressure in developing countries around the world.
A. Bahuguna, Srishti Rawat, D. Rawat
semanticscholar   +1 more source

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents.

Journal of Medicinal Chemistry, 2021
The benzothiazinone (BTZ) scaffold compound PBTZ169 kills Mycobacterium tuberculosis by inhibiting the essential flavoenzyme DprE1, consequently blocking the synthesis of the cell wall component arabinans.
Dongguang Fan, Bin Wang, G. Stelitano, Karin Savková, Rui Shi, Stanislav Huszár, Quanquan Han, K. Mikušová, L. Chiarelli, Yu Lu, Chunhua Qiao   +10 more
semanticscholar   +1 more source

Review of Recent Advances in Thiazolidin-4-One Derivatives as Promising Antitubercular Agents (2021–Present)

Molecules
Tuberculosis (TB) remains one of the leading causes of mortality worldwide, exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains. In the pursuit of novel therapeutic strategies,
Wiktoria Drzał, Nazar Trotsko
semanticscholar   +1 more source

Triazole: A Promising Antitubercular Agent

Chemical Biology & Drug Design, 2015
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share.
Rangappa S, Keri, Siddappa A, Patil, Srinivasa, Budagumpi, Bhari Mallanna, Nagaraja   +3 more
openaire   +2 more sources