Results 1 to 10 of about 9,317 (159)

Early cardiovascular collapse after envenoming by snakes in Australia, 2005-2020: an observational study (ASP-31). [PDF]

Med J Aust
Abstract Objectives To investigate the frequency, timing, and characteristics of cardiovascular collapse after snakebite in Australia, and the complications of collapse following envenoming. Study design Observational study; analysis of prospectively collected demographic and clinical data.
Isbister GK, Isoardi KZ, Chiew AL, Jenkins S, Buckley NA.   +4 more
europepmc   +2 more sources

Efficacy and safety of two Antivenoms in the treatment of eastern copperhead (Agkistrodon contortrix) envenomations in Southeast Texas. [PDF]

J Am Coll Emerg Physicians Open
Abstract Background There are two Food and Drug Administration–approved antivenoms for the treatment of North American pitviper envenomations: Crotalidae polyvalent immune fab (ovine) (CroFab, henceforth FabAV) and Crotalidae immune F(ab’)2 (equine) (Anavip, henceforth Fab2AV).
Greene S, Teshon A.
europepmc   +2 more sources

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J., Gay, Claudia Carolina, Pla, Davinia, Sanz, Libia   +3 more
core   +9 more sources

Venoms, venomics, antivenomics [PDF]

FEBS Letters, 2009
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, and evolution of snake venoms. Our long‐term goal is to gain a deep insight of all viperid venom proteomes.
Calvete Chornet, Juan José, Sanz, Libia, Angulo Ugalde, Yamileth, Lomonte, Bruno, Gutiérrez, José María   +4 more
openaire   +5 more sources

Polyspecific snake antivenom may help in antivenom crisis [PDF]

BMJ, 2003
EDITOR—In Africa snakebites cause thousands of deaths annually and much permanent physical disability, but the supply of antivenom, the only specific treatment, is threatened by commercial pressures and privatisation. This has been caused over the past few years by the cessation of antivenom manufacture by Behringwerke in Germany, greatly reduced ...
Laing, G, Harrison, R, Theakston, R, Renjifo, J, Nasidi, A, Gutierrez, J, Warrell, D   +6 more
openaire   +5 more sources

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Snakebite: An Exploratory Cost-Effectiveness Analysis of Adjunct Treatment Strategies. [PDF]

, 2018
The cost-effectiveness of the standard of care for snakebite treatment, antivenom, and supportive care has been established in various settings. In this study, based on data from South Indian private health-care providers, we address an additional ...
Bulfone, Tommaso C, Herzel, Benjamin J, Kahn, James G, Lewin, Matthew, Raj, C Soundara, Samuel, Stephen P   +5 more
core   +2 more sources

A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins [PDF]

, 2018
Antivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease.
Arnold, Beerli, Bendandi, Bolanos, Chippaux, Elena, Frauches, Gene, Graham, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Harrison, Julve, Laustsen, Laustsen, Lavonas, Marillonnet, Marillonnet, Paul, Paul, Pla, Qiu, Ramos, Rasmussen, Sarrion-Perdigones, Segura, Soller, Stock, Stoger, Syller, Theakston, Walwyn, Wang, Zheng   +38 more
core   +2 more sources

Antivenoms for Snakebite Envenomings

Inflammation & Allergy - Drug Targets, 2011
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. Antivenoms are manufactured by immunizing animals, usually horses, with venoms from a single or several medically-relevant snake species. Antivenoms are constituted by either whole IgG molecules or the immunoglobulin fragments F(ab')₂ and Fab, obtained by ...
Gutiérrez, José María, León Montero, Guillermo, Lomonte, Bruno, Angulo Ugalde, Yamileth   +3 more
openaire   +5 more sources

Histopathological analysis and in situ localisation of Australian tiger snake venom in two clinically envenomed domestic animals [PDF]

, 2011
Objective: To assess histopathological changes in clinically envenomed tiger snake patients and identify tissue specific localisation of venom toxins using immunohistochemistry.
Balmer, L., Brown, S.G.A., Davern, K.M., Jacoby-Alner, T.E., Stephens, N., Swindells, K.   +5 more
core   +2 more sources