Results 11 to 20 of about 17,918 (294)

Indian Polyvalent Antivenom Accelerates Recovery From Venom-Induced Consumption Coagulopathy (VICC) in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming

Frontiers in Medicine, 2022
BackgroundVenom-induced consumption coagulopathy (VICC) is an important clinical consequence of Russell’s viper (Daboia russelii) envenoming. There is limited evidence for antivenom effectiveness in resolving VICC.
Anjana Silva, Anjana Silva, Anjana Silva, Fiona E. Scorgie, Lisa F. Lincz, Kalana Maduwage, Sisira Siribaddana, Geoffrey K. Isbister, Geoffrey K. Isbister   +8 more
doaj   +2 more sources

Evaluating Antivenom Efficacy against Echis carinatus Venoms—Screening for In Vitro Alternatives

Toxins, 2022
In India, polyvalent antivenom is the mainstay treatment for snakebite envenoming. Due to batch-to-batch variation in antivenom production, manufacturers have to estimate its efficacy at each stage of IgG purification using the median effective dose ...
Siddharth Bhatia, Avni Blotra, Karthikeyan Vasudevan   +2 more
doaj   +2 more sources

Early Adverse Reactions to Snake Antivenom: Poison Center Data Analysis

Toxins, 2022
Antivenom is an essential treatment for snake envenomation; however, early adverse reactions (EARs) are major limitations to its use. We performed a retrospective cross-sectional study using Ramathibodi Poison Center data (January 2016 to December 2017 ...
Charuwan Sriapha, Panee Rittilert, Taksa Vasaruchapong, Sahaphume Srisuma, Winai Wananukul, Satariya Trakulsrichai   +5 more
doaj   +2 more sources

Adverse Reactions after Administration of Antivenom in Korea

Toxins, 2020
Kovax® antivenom is the main treatment for toxins produced by the Gloydius species. However, research on adverse reactions after Kovax® antivenom administration is scarce.
Jin Seok Shim, Hyunggoo Kang, Yongil Cho, Hyungoo Shin, Heekyung Lee   +4 more
doaj   +2 more sources

A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization

Toxins, 2021
Massive, Africanized honeybee attacks have increased in Brazil over the years. Humans and animals present local and systemic effects after envenomation, and there is no specific treatment for this potentially lethal event.
Jhonatha Mota Teixeira-Cruz, Marcelo Abrahão Strauch, Marcos Monteiro-Machado, Matheus Silva Tavares-Henriques, João Alfredo de Moraes, Luís Eduardo Ribeiro da Cunha, Rui Seabra Ferreira, Benedito Barraviera, Luis Eduardo M. Quintas, Paulo A. Melo   +9 more
doaj   +2 more sources

Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Snake bite is one of the most neglected public health issues in poor rural communities worldwide. In addition to the clinical effects of envenoming, treatment with antivenom frequently causes serious adverse reactions, including ...
Shelley F Stone, Geoffrey K Isbister, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Ariaranee Ariaratnam, Tamara E Jacoby-Alner, Claire L Cotterell, Simon G A Brown   +9 more
doaj   +3 more sources

Snake antivenom for snake venom induced consumption coagulopathy [PDF]

, 2015
Background Snake venom induced consumption coagulopathy is a major systemic effect of envenoming. Observational studies suggest that antivenom improves outcomes for venom induced consumption coagulopathy in some snakebites and not others. However, the
Allen, Gawarammana, Isbister, Isbister, Isbister, Isbister, Isbister, Isbister, Joseph, Kasturiratne, Lalloo, Mion, Nuchprayoon, Rosing, Rosing, Sanchez, Silva, Swenson, Tans   +18 more
core   +3 more sources

Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial.

PLoS Medicine, 2011
BackgroundEnvenoming from snakebites is most effectively treated by antivenom. However, the antivenom available in South Asian countries commonly causes acute allergic reactions, anaphylactic reactions being particularly serious.
H Asita de Silva, Arunasalam Pathmeswaran, Channa D Ranasinha, Shaluka Jayamanne, Senarath B Samarakoon, Ariyasena Hittharage, Ranjith Kalupahana, G Asoka Ratnatilaka, Wimalasiri Uluwatthage, Jeffrey K Aronson, Jane M Armitage, David G Lalloo, H Janaka de Silva   +12 more
doaj   +2 more sources

Clinical effects and antivenom dosing in brown snake (Pseudonaja spp.) envenoming--Australian snakebite project (ASP-14). [PDF]

PLoS ONE, 2012
BACKGROUND: Snakebite is a global health issue and treatment with antivenom continues to be problematic. Brown snakes (genus Pseudonaja) are the most medically important group of Australian snakes and there is controversy over the dose of brown snake ...
George E Allen, Simon G A Brown, Nicholas A Buckley, Margaret A O'Leary, Colin B Page, Bart J Currie, Julian White, Geoffrey K Isbister, ASP Investigators   +8 more
doaj   +3 more sources

Comparison of F(ab') versus Fab antivenom for pit viper envenomation: A prospective, blinded, multicenter, randomized clinical trial [PDF]

, 2014
BACKGROUND: Crotalidae Polyvalent Immune Fab (Ovine) has been the only antivenom commercially available in the US since 2007 for treatment of Crotalinae envenomation.
Alejandro Alagón, Anne-Michelle Ruha, Boyer LV, Brandon J. Lewis, Bush SP, CroFab®, Dan Quan, David L. Morgan, Dawn R. Sollee, Eric A. Toschlog, Farshad M. Shirazi, Gary R. Figge, Holm S, Ives de Chazal, Landon J, Leslie V. Boyer, Meyer WP, Norris RL, Richard D. Gerkin, Richard F. Clark, Robert Wolk, Sean P. Bush, Seifert SA, Stephen W. Borron, Steven A. Seifert, Thomas C. Arnold, Walter García-Ubbelohde, William J. Meggs   +27 more
core   +4 more sources