Results 31 to 40 of about 17,918 (294)

The Preclinical Evaluation of a Second-Generation Antivenom for Treating Snake Envenoming in India

Toxins, 2022
Snake envenoming afflicts the Indian subcontinent with the highest rates of mortality (47,000) and morbidity globally. The only effective treatment for snakebites is the administration of antivenom, which is produced by the hyperimmunisation of equines ...
Saurabh S. Attarde, Ashwin Iyer, Suyog Khochare, U. Shaligram, Mayur Vikharankar, K. Sunagar   +5 more
semanticscholar   +1 more source

Cytotoxic Effect of Bee (A. mellifera) Venom on Cancer Cell Lines

Journal of Pharmacopuncture, 2020
Objectives: Nowadays cancer treatment is an important challenge in the medical world that needs better therapies. Many active secretions produced by insects such as honey bees used to discover new anticancer drugs.
Sima Khalilifard Borojeni, Hossein Zolfagharian, Mahdi Babaie, Iraj Javadi   +3 more
doaj   +1 more source

Potential economic and clinical implications of improving access to snake antivenom in five ASEAN countries: A cost-effectiveness analysis

PLoS Neglected Tropical Diseases, 2022
Background Despite domestic production of antivenoms in the Association of Southeast Asian Nations (ASEAN) countries, not all victims with snakebite envenomings indicated for antivenom received the appropriate or adequate effective dose of antivenom due ...
C. Patikorn, A. Ismail, S. Z. Zainal Abidin, Iekhsan Othman, N. Chaiyakunapruk, S. Taychakhoonavudh   +5 more
semanticscholar   +1 more source

Biogeographic venom variation in Russell’s viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

PLoS Neglected Tropical Diseases, 2021
Background Snakebite in India results in over 58,000 fatalities and a vast number of morbidities annually. The majority of these clinically severe envenomings are attributed to Russell’s viper (Daboia russelii), which has a near pan-India distribution ...
R. R. Senji Laxme, Suyog Khochare, Saurabh S. Attarde, Vivek Suranse, Ashwin Iyer, N. Casewell, R. Whitaker, G. Martin, K. Sunagar   +8 more
semanticscholar   +1 more source

A painful journey to antivenom: The therapeutic itinerary of snakebite patients in the Brazilian Amazon (The QUALISnake Study)

PLoS Neglected Tropical Diseases, 2021
Access to antivenoms is not guarranteed for vulnerable populations that inhabit remote areas in the Amazon. The study of therapeutic itineraries (TI) for treatment of snakebites would support strategies to provide timely access to users.
J. Cristino, G. M. Salazar, Vinícius Azevedo Machado, E. Honorato, A. Farias, J. Vissoci, Alexandre Vilhena Silva Neto, M. Lacerda, F. H. Wen, W. Monteiro, Jacqueline A G Sachett   +10 more
semanticscholar   +1 more source

Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell’s viper (Daboia russelii) venoms

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background: The western Russell’s viper (Daboia russelii) is widely distributed in South Asia, and geographical venom variation is anticipated among distant populations.
T. Faisal, K. Y. Tan, N. Tan, S. Sim, C. A. Gnanathasan, Choo Hock Tan   +5 more
semanticscholar   +1 more source

Experimental Bothrops atrox envenomation: Efficacy of antivenom therapy and the combination of Bothrops antivenom with dexamethasone. [PDF]

PLoS Neglected Tropical Diseases, 2017
Bothrops atrox snakes are the leading cause of snake bites in Northern Brazil. The venom of this snake is not included in the antigen pool used to obtain the Bothrops antivenom. There are discrepancies in reports on the effectiveness of this antivenom to
Gabriella Neves Leal Santos Barreto, Sâmella Silva de Oliveira, Isabelle Valle Dos Anjos, Hipocrates de Menezes Chalkidis, Rosa Helena Veras Mourão, Ana Maria Moura-da-Silva, Ida Sigueko Sano-Martins, Luis Roberto de Camargo Gonçalves   +7 more
doaj   +1 more source

A Quest for a Universal Plasma-Derived Antivenom Against All Elapid Neurotoxic Snake Venoms

Frontiers in Immunology, 2021
This review describes the research aimed at the development of universal antivenom against elapid neurotoxic snake venoms. The antivenoms produced in Thailand in the 1980s were of low potency, especially against the elapid venoms.
K. Ratanabanangkoon
semanticscholar   +1 more source

Pan-American Lancehead Pit-Vipers: Coagulotoxic Venom Effects and Antivenom Neutralisation of Bothrops asper and B. atrox Geographical Variants

Toxins, 2021
The toxin composition of snake venoms and, thus, their functional activity, can vary between and within species. Intraspecific venom variation across a species’ geographic range is a major concern for antivenom treatment of envenomations, particularly ...
L. Bourke, C. Zdenek, E. Neri-Castro, Melisa Bénard-Valle, A. Alagón, J. Gutiérrez, E. Sanchez, Matt Aldridge, B. Fry   +8 more
semanticscholar   +1 more source

Snake Venom Proteomics of Samar Cobra (Naja samarensis) from the Southern Philippines: Short Alpha-Neurotoxins as the Dominant Lethal Component Weakly Cross-Neutralized by the Philippine Cobra Antivenom

Frontiers in Pharmacology, 2021
The Samar Cobra, Naja samarensis, is endemic to the southern Philippines and is a WHO-listed Category 1 venomous snake species of medical importance. Envenomation caused by N.
Praneetha Palasuberniam, Y. Chan, K. Y. Tan, Choo Hock Tan   +3 more
semanticscholar   +1 more source