Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]
, 2020 Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B. +12 more
core +1 more source
Experimental Bothrops atrox envenomation: Efficacy of antivenom therapy and the combination of Bothrops antivenom with dexamethasone. [PDF]
PLoS Neglected Tropical Diseases, 2017 Bothrops atrox snakes are the leading cause of snake bites in Northern Brazil. The venom of this snake is not included in the antigen pool used to obtain the Bothrops antivenom. There are discrepancies in reports on the effectiveness of this antivenom to
Gabriella Neves Leal Santos Barreto +7 more
doaj +1 more source
Snakebite: An Exploratory Cost-Effectiveness Analysis of Adjunct Treatment Strategies. [PDF]
, 2018 The cost-effectiveness of the standard of care for snakebite treatment, antivenom, and supportive care has been established in various settings. In this study, based on data from South Indian private health-care providers, we address an additional ...
Bulfone, Tommaso C +5 more
core +2 more sources
Toxins, 2016 Venom detection is crucial for confirmation of envenomation and snake type in snake-bite patients. Enzyme immunoassay (EIA) is used to detect venom, but antivenom in samples prevents venom detection.
Kalana P. Maduwage +3 more
doaj +1 more source
Antivenoms for Snakebite Envenomings
Inflammation & Allergy - Drug Targets, 2011 Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. Antivenoms are manufactured by immunizing animals, usually horses, with venoms from a single or several medically-relevant snake species. Antivenoms are constituted by either whole IgG molecules or the immunoglobulin fragments F(ab')₂ and Fab, obtained by ...
Gutiérrez, José María +3 more
openaire +5 more sources
Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites. [PDF]
PLoS Neglected Tropical Diseases, 2015 There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell's viper bites.Patient data and serial blood samples were collected from patients with ...
Geoffrey K Isbister +13 more
doaj +1 more source
Funnel-web spider bite: a systematic review of recorded clinical cases [PDF]
, 2005 The document attached has been archived with permission from the editor of the Medical Journal of Australia (09 January 2008). An external link to the publisher’s copy is included.Objective: To investigate species-specific envenoming rates and spectrum ...
Balit, C. +9 more
core +2 more sources
Snakebites: costing recombinant antivenoms [PDF]
Nature, 2016 Andreas H. Laustsen
openalex +4 more sources
Antivenom supply and demand: An analysis of antivenom availability and utilization in South Africa
African Journal of Emergency Medicine, 2023 Snakebites are a neglected tropical disease. In many areas, envenoming incidence and antivenom administration rates are unknown. This study compared antivenom (AV) availability to rates of envenoming and recommendations to treat (RTT) in South Africa.This retrospective study identified, extracted, and reviewed all cases of envenoming (snake bites and ...
Natalie R Neumann +6 more
openaire +3 more sources
Effectiveness of repeated antivenom therapy for snakebite-related systemic complications
Journal of International Medical Research, 2019 Objective This study aimed to determine the effect of repeated antivenom therapy compared with that of single antivenom therapy for treating snakebite-related systemic complications.
Kyung Hoon Park +7 more
doaj +1 more source